scholarly journals In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis

2020 ◽  
Vol 54 (2) ◽  
pp. 385-396 ◽  
Author(s):  
Nikhil Rai ◽  
Trishna Bal ◽  
Sabyasachi Swain
Keyword(s):  
Drug Delivery ◽  
Free Radical ◽  
Graft Copolymer ◽  
Controlled Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device

A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device

2012 ◽  
Author(s):  
Letia Blanco ◽  
Panos S. Shiakolas ◽  
Pranesh B. Aswath ◽  
Christopher B. Alberts ◽  
Chris Grace ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Controlled Drug Delivery ◽  
Solution Temperature ◽  
Delivery Device ◽  
Element Analysis ◽  
Loop Control ◽  
Glycol Diacrylate ◽  
Drug Delivery Device ◽  
And Performance

Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be reviewed and discussed. A parametric study was performed to examine the device operation and performance as function of hydrogel heating/cooling temperature profiles. Subsequently, the device was employed in a series of experiments to examine the delivery of a protein as a function of thermal stimuli. The matrix used in this study was poly(ethylene glycol) diacrylate (PEGDA) and the drug delivery nanoparticles carriers were poly(N-isopropylacrylamide-co-acrylamide (PNIPAM) with a lower critical solution temperature (LCST) around 40°C. The protein of choice was bovine serum albumin (BSA). The results of this study illustrate that the development of a multi-drug or therapeutic delivery device is possible and that individual drugs can be delivered on demand using a closed loop control system.

DC Bead: In Vitro Characterization of a Drug-delivery Device for Transarterial Chemoembolization

2006 ◽  
Vol 17 (2) ◽  
pp. 335-342 ◽  
Author(s):  
Andrew L. Lewis ◽  
M. Victoria Gonzalez ◽  
Andrew W. Lloyd ◽  
Brenda Hall ◽  
Yiqing Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transarterial Chemoembolization ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
In Vitro Characterization

Biologically Inspired Robotic Microswimmers

2009 ◽  
Author(s):  
William R. Hesse ◽  
Matthew Federici ◽  
David M. Casale ◽  
Peter Fink ◽  
Basil Milton ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Reynolds Number ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Specific Cell ◽  
Delivery Device ◽  
Biologically Inspired ◽  
Profound Impact ◽  
Drug Delivery Device

Drug delivery systems have had a profound impact on several branches of medicine. Engineers and researchers alike have labored to create a controlled drug delivery device capable of regulated dosage release and a specific cell targeting mechanism. The growing field of biomimicry has inspired several of these drug systems, though success has been limited. The flagellated low Reynolds number propulsion system of Salmonella typhimurium has inspired this specific delivery complex. In this system, the helical flagellar filaments of S. typhimurium are isolated from the bacteria’s cell body and are bound to functionalized paramagnetic microspheres. As a magnetic field is applied to this device, the microsphere rotates, inducing rotation of the helical flagella. This motion creates a locomotive force and drives the device in a predestined direction.

scholarly journals Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9115-9122 ◽  
Author(s):  
L. B. de Paula ◽  
F. L. Primo ◽  
M. R. Pinto ◽  
P. C. Morais ◽  
A. C. Tedesco
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Maghemite Nanoparticles ◽  
Delivery Device ◽  
Drug Delivery Device

The study describes the development of magnetic nanoemulsion loaded with citrate-coated maghemite nanoparticles and photosensitizer and the in vitro studies using cell lines while combining the use of hyperthermia and photodynamic therapy therapies.

In Vitro–In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

2018 ◽  
Vol 107 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Angus R. Hibbins ◽  
Mershen Govender ◽  
Sunaina Indermun ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salmon Calcitonin ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device
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