Formulation and Evaluation of Hydrocortisone Sodium Succinate Mucoadhesive Buccal Tablet

SummaryThe radioactive adenosine 3′,5′-monophosphate (cyclic AMP) level derived from 8-14C adenine in intact rabbit platelets decreased in the presence of mitochondrial inhibitor (potassium cyanide) or uncoupler (sodium azide), and markedly increased by the addition of NaF, monoiodoacetic acid (MIA), or 2-deoxy-D-glucose. The stimulative effect of the glycolytic inhibitors was distinctly enhanced by the simultaneous addition of sodium succinate. MIA did neither directly stimulate the adenyl cyclase activity nor inhibit the phosphodiesterase activity. These results suggest that cyclic AMP synthesis in platelets is closely linked to mitochondrial oxidative phosphorylation.

Download Full-text

Faculty Opinions recommendation of Aberrant drug-related behavior observed during clinical studies involving patients taking chronic opioid therapy for persistent pain and fentanyl buccal tablet for breakthrough pain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8959957.9519056 ◽

2011 ◽

Author(s):

Marcin Chwistek

Keyword(s):

Clinical Studies ◽

Breakthrough Pain ◽

Opioid Therapy ◽

Persistent Pain ◽

Chronic Opioid Therapy ◽

Fentanyl Buccal Tablet ◽

Buccal Tablet

Download Full-text

Dose Proportionality of Fentanyl Buccal Tablet in Doses Ranging from 600 to 1300 μg in Healthy Adult Subjects

Clinical Drug Investigation ◽

10.2165/11533360-000000000-00000 ◽

2010 ◽

pp. 1

Author(s):

Mona Darwish ◽

Mary Kirby ◽

Philmore Robertson ◽

William Tracewell ◽

Fang Xie

Keyword(s):

Healthy Adult ◽

Dose Proportionality ◽

Fentanyl Buccal Tablet ◽

Buccal Tablet

Download Full-text

Development of Mucoadhesive Buccal Drug Delivery System of Propranolol Hydrochloride Using Aster ericoides Mucilage

Drug Delivery Letters ◽

10.2174/2210303109666191010164201 ◽

2020 ◽

Vol 10 (2) ◽

pp. 133-148

Author(s):

Ankaj Kaundal ◽

Pravin Kumar ◽

Rajendra Awasthi ◽

Giriraj T. Kulkarni

Keyword(s):

Buccal Cavity ◽

Three Dimensional ◽

Hot Water ◽

Fickian Diffusion ◽

Aster Ericoides ◽

Dimensional Network ◽

Buccal Tablet ◽

Significant Difference ◽

Volunteer Group

Aim: The study was aimed to develop mucoadhesive buccal tablets using Aster ericoides leaves mucilage. Background : Mucilages are naturally occurring high-molecular-weight polyuronides, which have been extensively studied for their application in different pharmaceutical dosage forms. Objective: The objective of the present research was to establish the mucilage isolated from the leaves of Aster ericoides as an excipient for the formulation of the mucoadhesive buccal tablet. Method: The mucilage was isolated from the leaves of Aster ericoides by maceration, precipitated with acetone and characterized. Tablets were prepared using wet granulation technique and evaluated for various official tests. Results: The mucilage was found to be non-toxic on A-431 and Vero cell lines. It was insoluble but swellable in cold and hot water. The results indicate that mucilage can form a three-dimensional network. The pH of the mucilage (6.82 ± 0.13) indicated that it might be non-irritant to the buccal cavity. The mucilage was found to be free from microbes. The release of drug was by Fickian diffusion. The in vivo buccal tablet acceptance was 80%. No significant difference between the diastolic blood pressure of standard and Aster tablets treated volunteer group was recorded. Conclusion: The mucilage was found to be non-toxic on A-431 and Vero cell lines. It was insoluble but swellable in cold and hot water. The results indicate that mucilage can form a three-dimensional network. The pH of the mucilage (6.82 ± 0.13) indicated that it might be non-irritant to the buccal cavity. The mucilage was found to be free from microbes. The release of drug was by Fickian diffusion. The in vivo buccal tablet acceptance was 80%. No significant difference between the diastolic blood pressure of standard and Aster tablets treated volunteer group was recorded. Other: However, to prove the potency of the polymer, in vivo bioavailability studies in human volunteers are needed along with chronic toxicity studies in suitable animal models.

Download Full-text