A series of diazenyl chalcones was prepared by base catalyzed Claisen-Schmidt condensation
of synthesized hydroxy substituted acetophenone azo dye with various substituted aromatic/
heteroaromatic aldehydes. The structural conformation of synthesized chalcones was done by a
number of physicochemical and spectral means like FTIR, UV-visible, mass, NMR spectroscopy and
CHNS/O analysis. These diazenyl chalcones were assessed for their in vitro antimicrobial potential
against several Gram-negative, Gram-positive bacterial and fungal strains by serial tube dilution
method. The fluconazole and cefadroxil were used as standard drugs. The target compounds were also
evaluated for their antioxidant potential by DPPH assay. (2E)-3-(2,4-Dichlorophenyl)-1-(4-((2,6-
dihydroxyphenyl)diazenyl)phenyl)prop-2-en-1-one (C-7) had shown very good antimicrobial potential
with MIC ranges from 3.79 to 15.76 μg/ml against most of the tested microorganisms. Most of the
synthesized diazenyl chalcones were found to be active against B. subtilis. The (2E)-1-(5-((2-Chloro-
4-nitrophenyl)diazenyl)-2-hydroxyphenyl)-3-(2-hydroxynaphthalen-1-yl)prop-2-en-1-one (C-10) had
shown high free radical-scavenging activity when compared with the ascorbic acid as the reference
antioxidant.
Evaluating the Antimicrobial Potential of Eucalyptus baileyana F. Muell. and Eucalyptus major (Maiden) Blakely against the Fish Spoilage-causing Bacterium Shewanella putrefaciens
