scholarly journals Inhibition of Post-Heparin Lipolytic Activity by Lipid Peroxide

1982 ◽  
Vol 10 (4) ◽  
pp. 767-770
Author(s):  
Kazunari WADA ◽  
Hideo MIKI ◽  
Fumio OKUDA ◽  
Masahiko ETOH ◽  
Reizo KUSUKAWA
Keyword(s):  
Lipolytic Activity ◽  
Lipid Peroxide ◽  
Post Heparin Lipolytic Activity

scholarly journals Lipid Lowering Activity ofAnthocephalus indicusRoot in Hyperlipidemic Rats

2010 ◽  
Vol 7 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Vishnu Kumar ◽  
Mohammad Mubin Khan ◽  
Ashok Kumar Khanna ◽  
Ranjana Singh ◽  
Sushma Singh ◽  
...  
Keyword(s):  
Hydroxyl Radicals ◽  
Plasma Lipids ◽  
Antioxidant Activities ◽  
Lipolytic Activity ◽  
Lipid Lowering ◽  
Root Extract ◽  
Superoxide Anions ◽  
Post Heparin Lipolytic Activity ◽  
Lowering Activity

The lipid lowering activity ofAnthocephalus indicus(family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems,in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract ofA. indicus, which could help prevention of hyperlipidemia and related diseases.

Lipolytic Activities in Post-Heparin Plasma in Man Measured with Different Substrate Emulsions

1978 ◽  
Vol 54 (2) ◽  
pp. 201-203
Author(s):  
B. Vessby ◽  
J. Boberg ◽  
H. Lithell
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipolytic Activity ◽  
Heparin Plasma ◽  
Post Heparin Lipolytic Activity

1. Post-heparin lipolytic activity in man has been studied by using a triglyceride substrate emulsion containing different emulsifiers. 2. The lipolytic activity measured was profoundly influenced by the type of emulsifier used in the substrate. Substrates stabilized by synthetic emulsifiers give higher lipolytic activity than Intralipid, which contains egg phospholipids as emulsifiers. This difference was solely explained by higher salt-resistant lipase activities found with emulsions containing synthetic emulsifiers. The salt-inhibited lipase activity, which has properties as a lipoprotein lipase, was not influenced by the type of emulsifier. 3. When used under specified conditions Intralipid seems to be virtually specific for extrahepatic post-heparin lipolytic activity.

Modifications of Plasma Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity Induced in the Rat by Acute Administration of Ethanol or Propan-2-ol

1975 ◽  
Vol 48 (2) ◽  
pp. 153-156
Author(s):  
Y. Giudicelli ◽  
R. Nordmann ◽  
J. Nordmann
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipolytic Activity ◽  
Ethanol Administration ◽  
Acute Administration ◽  
Post Heparin Lipolytic Activity ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Made In

1. The oral administration of propan-2-ol [isopropanol; 100 mmol (6 g)/kg body weight] or ethanol [130 mmol (6 g)/kg body weight] to starved rats produced no change in plasma post-heparin lipase activity (PHLA) compared with that observed in 154 mmol/l sodium chloride (saline)-treated rats. 2. An increase of adipose tissue lipoprotein lipase (LLA) and a decrease of heart LLA occurred in isopropanol-treated animals, whereas no significant changes were found in these activities after ethanol administration. 3. Since administration of isopropanol produces hyperglycaemia, observations were also made in rats receiving glucose infusion rather than saline. In these animals a rise in PHLA and adipose tissue LLA, and a fall in heart LLA, occurred. 4. It is suggested that the changes in tissue LLA produced by isopropanol are mediated by the rise in blood glucose.

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