Gas Gangrene Of The Liver With Acute Liver Failure And Septic Shock Syndrome Caused By Clostridium Perfringens

10.5580/2400 ◽  
2003 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Septic Shock ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clostridium Perfringens ◽  
Gas Gangrene

scholarly journals The Use of Methylene Blue during Liver Transplantation for Vasoplegia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Paul Harding ◽  
Thomas Nicholas ◽  
Cale Kassel
Keyword(s):  
Septic Shock ◽  
Methylene Blue ◽  
Liver Transplantation ◽  
Cardiopulmonary Bypass ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Treatment Option ◽  
Case Reports ◽  
Refractory Hypotension

The use of methylene blue for vasoplegia in cardiac cases with cardiopulmonary bypass, septic shock, and acute liver failure is well documented. Use of MB for liver transplantation has been largely limited to case reports. We describe three separate liver transplantation patients with significant hypotension following reperfusion. Administration of methylene blue to each patient resulted in a significant decrease in vasopressor medication and two patients weaned completely. We argue that the use of MB should be considered as a treatment option for refractory hypotension.

Hemodynamics and metabolic studies on septic shock in patients with acute liver failure

2008 ◽  
Vol 23 (4) ◽  
pp. 468-472 ◽  
Author(s):  
Ming-Hung Tsai ◽  
Yung-Chang Chen ◽  
Jau-Min Lien ◽  
Ya-Chung Tian ◽  
Yun-shing Peng ◽  
...  
Keyword(s):  
Septic Shock ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Metabolic Studies

scholarly journals L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Thorsten Brenner ◽  
Thomas H. Fleming ◽  
Claudia Rosenhagen ◽  
Ute Krauser ◽  
Markus Mieth ◽  
...  
Keyword(s):  
Septic Shock ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Healthy Volunteers ◽  
Asymmetric Dimethylarginine ◽  
Plasma Concentrations ◽  
Hepatic Function ◽  
Surgical Patients ◽  
Enzyme Linked Immunosorbent Assay ◽  
Early Predictors

Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical patients and 30 healthy volunteers using enzyme linked immunosorbent assay (ELISA) kits. Plasma samples from patients with septic shock were collected at sepsis onset, and 24 h, 4 d, 7 d, 14 d and 28 d later. Samples from surgical patients were collected prior to surgery, immediately after the end of the surgical procedure as well as 24 h later and from healthy volunteers once. In comparison to healthy volunteers and surgical patients, individuals with septic shock showed significantly increased levels of ADMA, as well as a decrease in the ratio of L-arg and ADMA at all timepoints. In septic patients with an acute liver failure (ALF), plasma levels of ADMA and L-arg were significantly increased in comparison to septic patients with an intact hepatic function. In summary it can be stated, that bioavailability of NO is reduced in septic shock. Moreover, measurements of ADMA and L-arg appear to be early predictors for survival in patients with sepsis-associated ALF.

scholarly journals Pericarditis caused by Enterococcus faecium with acute liver failure treated by a multifaceted approach including antimicrobials and hemoadsorption

2021 ◽  
Author(s):  
Thomas Köhler ◽  
Mathias W. Pletz ◽  
Simon Altmann ◽  
Carmen Kirchner ◽  
Elke Schwier ◽  
...  
Keyword(s):  
Septic Shock ◽  
Liver Function ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Enterococcus Faecium ◽  
Complex Case ◽  
Still Life ◽  
Sustained Reduction ◽  
Liver Function Testing ◽  
Sepsis And Septic Shock

Abstract BackgroundSepsis and septic shock are still life-threatening diseases with a high mortality rate. We report a complex case of peritonitis with pericarditis and acute liver failure caused by septic shock. Potentially hepato-toxic antibiotic therapy levels were monitored using the liver maximum capacity (LiMAx®) test and standard treatment was supplemented by adjunctive hemoadsorption with CytoSorb®. Case presentationThe case features a 29-year-old woman with a history of Crohn's disease and cachexia. Peritonitis caused by Enterococcus faecium was diagnosed later due to an ileum perforation. The hematogenic spread led to the pericarditis. In addition, sepsis-related acute-liver-failure complicated antimicrobial therapy further. The combination of standard therapy, anti-infective medication and blood purification was associated with inflammation control, hemodynamic stabilization and a concomitant decrease in vasopressor support. An efficient, sustained reduction in plasma bilirubin levels was achieved while maintaining liver function.ConclusionsThis case shows how complex infectious diseases with an atypical infectious focus resulting in septic shock can be successfully treated. A combination of antimicrobial (tigecycline and caspofungin) and long-term adjunctive hemoadsorption therapy was administered while hepato-toxic antibiotic medication was monitored by liver function testing.

scholarly journals Pericarditis Caused by Enterococcus faecium with Acute Liver Failure Treated by a Multifaceted Approach including Antimicrobials and Hemoadsorption

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Thomas Köhler ◽  
Mathias W. Pletz ◽  
Simon Altmann ◽  
Carmen Kirchner ◽  
Elke Schwier ◽  
...  
Keyword(s):  
Septic Shock ◽  
Liver Function ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Enterococcus Faecium ◽  
Complex Case ◽  
Still Life ◽  
Sustained Reduction ◽  
Liver Function Testing ◽  
Sepsis And Septic Shock

Background. Sepsis and septic shock are still life-threatening diseases with a high mortality rate. We report a complex case of peritonitis with pericarditis and acute liver failure caused by septic shock. Potentially hepatotoxic antibiotic therapy levels were monitored using the liver maximum capacity (LiMAx®) test, and standard treatment was supplemented by adjunctive hemoadsorption with CytoSorb®. Case Presentation. The case features a 29-year-old woman with a history of Crohn’s disease and cachexia. Peritonitis caused by Enterococcus faecium was diagnosed later due to an ileum perforation. The hematogenic spread led to pericarditis. In addition, sepsis-related acute liver failure complicated antimicrobial therapy further. The combination of standard therapy, anti-infective medication, and blood purification was associated with inflammation control, hemodynamic stabilization, and a concomitant decrease in vasopressor support. An efficient, sustained reduction in plasma bilirubin levels was achieved while maintaining liver function. Conclusions. This case shows how complex infectious diseases with an atypical infectious focus resulting in septic shock can be successfully treated. A combination of antimicrobial (tigecycline and caspofungin) and long-term adjunctive hemoadsorption therapy was administered while hepatotoxic antibiotic medication was monitored by liver function testing.

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