Optimization of cell-wall skeleton derived from Mycobacterium bovis BCG Tokyo 172 (SMP-105) emulsion in delayed-type hypersensitivity and antitumor models

2012 ◽  
Author(s):  
Miyauchi
Keyword(s):  
Cell Wall ◽  
Mycobacterium Bovis ◽  
Delayed Type Hypersensitivity ◽  
Mycobacterium Bovis Bcg

scholarly journals Induction of suppressor T cells in delayed-type hypersensitivity to Mycobacterium bovis BCG in low-responder mice

1980 ◽  
Vol 28 (2) ◽  
pp. 331-335
Author(s):  
R M Nakamura ◽  
T Tokunaga
Keyword(s):  
T Cells ◽  
Mycobacterium Bovis ◽  
Adoptive Transfer ◽  
Suppressor Cells ◽  
Delayed Type Hypersensitivity ◽  
Weak Effect ◽  
Spleen Cells ◽  
Suppressor T Cells ◽  
Mycobacterium Bovis Bcg ◽  
Low Responder

The induction of delayed-type hypersensitivity to Mycobacterium bovis BCG was specifically inhibited by suppressor T cells in C3H/He, a strain of mice which is a low responder to BCG. The existence of these suppressor cells was confirmed by an adoptive transfer of spleen cells of BCG-injected mice into cyclophosphamide-treated recipients. The suppressor cells appeared in the spleens of the mice 2 to 7 days after intravenous BCG injection. They were sensitive to anti-theta serum and complement and did not adhere to Sephadex G-10. A pretreatment of the mice with cyclophosphamide eliminated the suppression of delayed-type hypersensitivity. These suppressor cells effectively inhibited the induction of delayed-type hypersensitivity to BCG, but showed only weak effect on the expression of it.

scholarly journals Cell wall skeleton of Mycobacterium bovis BCG enhances the vaccine potential of antigen 85B against tuberculosis by inducing Th1 and Th17 responses

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213536 ◽  
Author(s):  
Yong Woo Back ◽  
Seunga Choi ◽  
Han-Gyu Choi ◽  
Ki-Won Shin ◽  
Yeo-Jin Son ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mycobacterium Bovis ◽  
Mycobacterium Bovis Bcg ◽  
Antigen 85B ◽  
Vaccine Potential
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