A COMPARATIVE STUDY OF SOME LIVER FUNCTION TESTS IN THE DIFFERENTIAL DIAGNOSIS OF JAUNDICE

1963 ◽  
Vol 1 (10) ◽  
pp. 346-350 ◽  
Author(s):  
B. R. Beveridge ◽  
G. M. Carter ◽  
R. A. Joske
Keyword(s):  
Differential Diagnosis ◽  
Liver Function ◽  
Comparative Study ◽  
Liver Function Tests ◽  
Function Tests

scholarly journals Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Lubna Danish ◽  
Riffat Siddiq ◽  
Sarwat Jahan ◽  
Mehwish Taneez ◽  
Manzoor Khan ◽  
...  
Keyword(s):  
Liver Function ◽  
Comparative Study ◽  
Protective Effect ◽  
Calcium Homeostasis ◽  
Liver Function Tests ◽  
Hepatoprotective Activity ◽  
Toxic Metabolite ◽  
Distilled Water ◽  
Function Tests ◽  
Higher Doses

Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.

scholarly journals IMPORTANCE OF LIVER FUNCTION TESTS IN DIFFERENTIAL DIAGNOSIS OF JAUNDICE

2015 ◽  
Vol 2 (46) ◽  
pp. 8220-8222
Author(s):  
Sandeep Barve ◽  
Darshana Patel ◽  
Shiromani K K ◽  
Ashish Jawarkar
Keyword(s):  
Differential Diagnosis ◽  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests
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