A DANGER OF SYMPATHOMIMETIC DRUGS

1966 ◽  
Vol 2 (12) ◽  
pp. 576-576 ◽  
Keyword(s):  
Sympathomimetic Drugs

Theograd, numotac and ventolin tablets

1970 ◽  
Vol 8 (24) ◽  
pp. 95-96
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular System ◽  
Bronchial Asthma ◽  
Bronchial Smooth Muscle ◽  
Airways Obstruction ◽  
Sympathomimetic Drugs

Theograd (Abbott), Numotac (Riker) and Ventolin Tablets (A & H) are oral bronchodilator preparations recently introduced for use in reversible airways obstruction occurring in bronchial asthma and bronchitis. Theograd is a preparation of theophylline, isoetharine (in Numotac) and salbutamol (Ventolin) are both sympathomimetic drugs which stimulate the adrenergic β receptors of bronchial smooth muscle more than those of the cardiovascular system.

SYMPATHOMIMETIC DRUGS IN ACUTE VIRAL BRONCHIOLITIS

PEDIATRICS ◽  
1969 ◽  
Vol 44 (4) ◽  
pp. 493-497 ◽  
Author(s):  
P. D. Phelan ◽  
H. E. Williams
Keyword(s):  
Pulmonary Resistance ◽  
Sympathomimetic Drugs ◽  
Before And After ◽  
Consistent Change ◽  
Acute Viral Bronchiolitis

Mean pulmonary resistance and inspiratory and expiratory pulmonary resistance were measured in 10 infants with acute viral bronchiolitis before and after the administration of isoprenaline or orciprenaline by aerosol. No consistent change in any measurement of pulmonary resistance was recorded following the administration of the drugs.

Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis

1994 ◽  
Vol 267 (5) ◽  
pp. E801-E804
Author(s):  
A. G. Dulloo ◽  
J. Seydoux ◽  
L. Girardier
Keyword(s):  
Parent Compound ◽  
Physiological Effect ◽  
Biologically Active ◽  
Adrenergic System ◽  
Sympathetic Control ◽  
Respiration Rates ◽  
Direct Demonstration ◽  
Brown Adipose ◽  
Sympathomimetic Drugs

The notion that paraxanthine (the major dimethylated by-product of caffeine) may be a biologically active metabolite that could mediate some of the effects of caffeine was tested in relation to the well-established property of caffeine as a thermogenic stimulant. From studies measuring the in vitro respiration rates of rat brown adipose tissue in the basal state and in response to ephedrine (an enhancer of norepinephrine release from sympathetic nerve endings), it is shown that paraxanthine has the same potency as its parent compound, caffeine, in interacting with the adrenergic system to potentiate thermogenesis. These data provide the first direct demonstration of a physiological effect of the main metabolite of caffeine and raise the possibility that paraxanthine may contribute importantly to the ability of caffeine to potentiate the thermogenic effects of well-known stimuli of the sympathetic nervous system such as cold exposure, moderate exercise, and sympathomimetic drugs.

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