Generalized Net Analyte Signal Standard Addition as a Novel Method for Simultaneous Determination: Application in Spectrophotometric Determination of Some Pesticides

2014 ◽  
Vol 97 (1) ◽  
pp. 252-258 ◽  
Author(s):  
Karim Asadpour-Zeynali ◽  
Elhameh Saeb ◽  
Javad Vallipour ◽  
Mehdi Bamorowat
Keyword(s):  
Spectrophotometric Determination ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Addition Method ◽  
Net Analyte Signal ◽  
Analyte Signal ◽  
Novel Method ◽  
Single Standard ◽  
Generalized Net

Abstract Simultaneous spectrophotometric determination of three neonicotinoid insecticides (acetamiprid,imidacloprid, and thiamethoxam) by a novel methodnamed generalized net analyte signal standard addition method (GNASSAM) in some binary and ternarysynthetic mixtures was investigated. For this purpose, standard addition was performed using a single standard solution consisting of a mixture ofstandards of all analytes. Savings in time and amount of used materials are some of the advantages of this method. All determinations showed appropriate applicability of this method with less than 5% error. This method may be applied for linearlydependent data in the presence of known interferents. The GNASSAM combines the advantages of both the generalized standard addition method and net analyte signal; therefore, it may be a properalternative for some other multivariate methods.

scholarly journals Net analyte signal standard addition method for the simultaneous determination of cadmium and nickel

2009 ◽  
Vol 74 (7) ◽  
pp. 789-799 ◽  
Author(s):  
Karim Asadpour-Zeynali ◽  
Reza Majidi ◽  
Masoud Tahmasebpour
Keyword(s):  
Simultaneous Determination ◽  
Standard Addition ◽  
Differential Pulse ◽  
Single Step ◽  
Standard Addition Method ◽  
Differential Pulse Polarography ◽  
Addition Method ◽  
Net Analyte Signal ◽  
Analyte Signal

A novel net analyte signal standard addition method (NASSAM) is presented for the simultaneous determination of Cd2+ and Ni2+ in their mixture by differential pulse polarography. The method combines the advantages of the standard addition method with the net analyte signal concept, which enables the extraction of information concerning a certain analyte from voltammograms of multi-component mixtures. This method has some advantages, such as: the use of a full voltammogram, realization in a single step, therefore it does not require calibration and prediction steps and only a few measurements are required for the determination. The simultaneous determination of Cd2+ and Ni2+ was performed in Britton-Robinson buffer (pH 2.87) and 0.40 M potassium thiocyanate solution.

scholarly journals Simultaneous Determination of Antazoline and Naphazoline by the Net Analyte Signal Standard Addition Method and Spectrophotometric Technique

2010 ◽  
Vol 93 (6) ◽  
pp. 1995-2001 ◽  
Author(s):  
Karim Asadpour-Zeynali ◽  
Raoof Ghavami ◽  
Roghayeh Esfandiari ◽  
Payam Soheili-Azad
Keyword(s):  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Standard Addition ◽  
Single Step ◽  
Standard Addition Method ◽  
Addition Method ◽  
Net Analyte Signal ◽  
Analyte Signal ◽  
Calibration Methods

Abstract A novel net analyte signal standard addition method (NASSAM) was used for simultaneous determination of the drugs anthazoline and naphazoline. The NASSAM can be applied for determination of analytes in the presence of known interferents. The proposed method is used to eliminate the calibration and prediction steps of multivariate calibration methods; the determination is carried out in a single step for each analyte. The accuracy of the predictions against the H-point standard addition method is independent of the shape of the analyte and interferent spectra. The net analyte signal concept was also used to calculate multivariate analytical figures of merit, such as LOD, selectivity, and sensitivity. The method was successfully applied to the simultaneous determination of anthazoline and naphazoline in a commercial eye drop sample.

scholarly journals H-point Standard Addition Method for the Simultaneous Spectrophotometric Determination of Captopril and Hydrochlorothiazide in Pharmaceutical Formulations

2021 ◽  
pp. 77-85
Keyword(s):  
Spectrophotometric Determination ◽  
Standard Addition ◽  
Pharmaceutical Formulations ◽  
Standard Addition Method ◽  
Addition Method ◽  
Real Samples ◽  
Relative Standard ◽  
Recovery Percentage ◽  
Precision And Accuracy

Simultaneous spectrophotometric determination of captopril and hydro-chlorothiazide in pharmaceutical formulations by the H-point standard addition method (HPSAM) is described. Absorbance at 211.5 and 230.3 nm was monitored upon the addition of standard solutions of captopril. The results showed that in prepared mixtures, captopril and hydrochlorothiazide can be determined simultaneously at concentration ratios varying from 1.0:0.8 to 2.5:1.5 μg/mL, respectively. Percentage recovery was found to be 95.33–104.37% for captopril and 96.8–105% for hydrochlorothiazide, with a relative standard deviation (RSD) of 2.46%. The method was successfully used to evaluate the antihypertensive captopril drug in a binary combination of hydrochlorothiazide in real samples with high precision and accuracy within the recovery percentage.

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