The COVID-19 pandemic has negatively affected the small and medium-sized enterprises (SMEs) in a significant manner. It has thrown some SMEs into a financial crunch, forced them to reduce/remove their workforce, hampered production due to prolonged lockdowns, halted their logistics and supply chain activities, and delayed their delivery schedules enormously. The revival of the SME sector is very important for the survival of the economy. One of the most important aspects of this revival strategy would be to innovate their existing supply chains for more visibility, transparency, and robustness through the adoption of affordable digital technologies. In spite of advanced studies in SC innovation, the in-depth studies related to this area of SMEs towards sustainability are still very scanty and inadequate. Therefore, this chapter proposes to develop a framework of SC Innovation for the sustainability of SMEs through a systematic literature review. This framework will be very useful to the owners and employees of SMEs and various researchers.