scholarly journals Gene Therapy of the Heart through Targeting Non-Cardiac Cells

10.5772/17424 ◽  
2011 ◽  
Author(s):  
Guro Valen
Keyword(s):  
Gene Therapy ◽  
Cardiac Cells

Confocal imaging of calcium in intact ventricular muscle provides a new view of excitation-contraction coupling

1996 ◽  
Vol 54 ◽  
pp. 738-739
Author(s):  
W.G. Wier
Keyword(s):  
Local Control ◽  
Cardiac Tissue ◽  
Cell Function ◽  
Isolated Heart ◽  
Cardiac Cells ◽  
Confocal Imaging ◽  
Ion Concentration ◽  
Heart Cell ◽  
Free Calcium ◽  
Heart Cells

A fundamentally new understanding of cardiac excitation-contraction (E-C) coupling is being developed from recent experimental work using confocal microscopy of single isolated heart cells. In particular, the transient change in intracellular free calcium ion concentration ([Ca2+]i transient) that activates muscle contraction is now viewed as resulting from the spatial and temporal summation of small (∼ 8 μm3), subcellular, stereotyped ‘local [Ca2+]i-transients' or, as they have been called, ‘calcium sparks'. This new understanding may be called ‘local control of E-C coupling'. The relevance to normal heart cell function of ‘local control, theory and the recent confocal data on spontaneous Ca2+ ‘sparks', and on electrically evoked local [Ca2+]i-transients has been unknown however, because the previous studies were all conducted on slack, internally perfused, single, enzymatically dissociated cardiac cells, at room temperature, usually with Cs+ replacing K+, and often in the presence of Ca2-channel blockers. The present work was undertaken to establish whether or not the concepts derived from these studies are in fact relevant to normal cardiac tissue under physiological conditions, by attempting to record local [Ca2+]i-transients, sparks (and Ca2+ waves) in intact, multi-cellular cardiac tissue.

Researchers Use Gene Therapy to Repair Inner-Ear Defects in Mice

ASHA Leader ◽  
2016 ◽  
Vol 21 (2) ◽  
Keyword(s):  
Gene Therapy ◽  
Inner Ear

Cyclooxygenese-2 promoter can mittigate the lethal toxicity in HSV-TK based adenoviral suicide gene therapy of gastrointestinal cancers

2001 ◽  
Vol 120 (5) ◽  
pp. A10-A10
Author(s):  
M YAMAMOTO ◽  
R ALEMANY ◽  
Y ADACHI ◽  
W GRIZZLE ◽  
D CURIEL
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers ◽  
Lethal Toxicity

Antiangiogenic gene therapy delays growth of murine and human pancreatic adenocarcinoma in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A349-A349
Author(s):  
J TSENG ◽  
F FARNEBO ◽  
O KISKER ◽  
C BECKER ◽  
C KUO ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Human Pancreatic Adenocarcinoma

1107: Evaluation of Cystine Transport in Cultured Human Kidney Cells: Primer to Gene Therapy of Cystinuria

2005 ◽  
Vol 173 (4S) ◽  
pp. 300-300
Author(s):  
Sreedhar Sagi ◽  
Lutz Trojan ◽  
Peter Aiken ◽  
Maurice S. Michel ◽  
Thomas Knoll
Keyword(s):  
Gene Therapy ◽  
Human Kidney ◽  
Kidney Cells

790: Interleukin-2 Enhanced the Anti-Tumor Effect of Adenoviral-Mediated HSV-TK Gene Therapy in Murine Bladder Cancer Model

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-214
Author(s):  
Shuji Terao ◽  
Toshiro Shirakawa ◽  
Kazumasa Goda ◽  
Sadao Kamidono ◽  
Akinobu Gotoh
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Interleukin 2 ◽  
Cancer Model ◽  
Bladder Cancer Model

622: Intravesical Interleukin-12 Gene Therapy in an Orthotopic Bladder Cancer Model

2006 ◽  
Vol 175 (4S) ◽  
pp. 200-201
Author(s):  
Minoru Horinaga ◽  
Kelley Harsch ◽  
Ryuichi Fukuyama ◽  
Warren Heston ◽  
William Larchian
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Interleukin 12 ◽  
Cancer Model ◽  
Bladder Cancer Model

1417: Mesenchymal Stem Cells Alone or Modified with ENOS Restore Erectile Function in the Aged Rat: Cell-Based Gene Therapy for Erectile Dysfunction

2004 ◽  
Vol 171 (4S) ◽  
pp. 373-373
Author(s):  
Trinity J. Bivalacqua ◽  
Mustafa F. Usta ◽  
Hunter C. Champion ◽  
Weiwen Deng ◽  
Philip J. Kadowitz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Erectile Dysfunction ◽  
Erectile Function ◽  
Aged Rat

972: Antisense CK2 Gene Therapy Induces Regression in Human Bladder Cancer Growing in Athymic Nude Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 257-258
Author(s):  
Joel Slaton ◽  
Daniel Sloper ◽  
Miriam Taylor ◽  
Alan Davis ◽  
Khalil Ahmed
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Nude Mice ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Athymic Nude Mice

967: A Targeted Radiotherapy and Tumour Specific Gene Therapy Approach for Bladder Cancer: Transfection of the Noradrenaline Transporter Gene Under the Control of Telomerase Promoters

2004 ◽  
Vol 171 (4S) ◽  
pp. 256-256
Author(s):  
Natasha E. Fullerton ◽  
Marie Boyd ◽  
Robert J. Mairs ◽  
Susan Ross ◽  
Lesley E.D. Wilson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Specific Gene ◽  
Transporter Gene ◽  
Targeted Radiotherapy ◽  
Therapy Approach ◽  
Noradrenaline Transporter ◽  
Gene Therapy Approach
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