scholarly journals Microinvasive Carcinoma of the Cervix

Author(s):  
Fernando Anschau ◽  
Chrystiane da Silva Marc ◽  
Maria Carolina ◽  
Manoel Afonso Guimares Gonalves

2015 ◽  
Vol 25 (Supp 1) ◽  
pp. 22-22
Author(s):  
C. A. Hartman ◽  
M. S.C. Gurgel ◽  
J. C. Teixeira ◽  
S. M. Figueiredo ◽  
J. Y. Yoneda ◽  
...  


Oncogene ◽  
2020 ◽  
Author(s):  
Romain Teinturier ◽  
Yakun Luo ◽  
Myriam Decaussin-Petrucci ◽  
Virginie Vlaeminck-Guillem ◽  
Francis Vacherot ◽  
...  


2021 ◽  
pp. 106689692110120
Author(s):  
Mingfei Yan ◽  
Phillip Bomeisl ◽  
Hannah Gilmore ◽  
Aparna Harbhajanka

Stratifying ductal carcinoma in situ (DCIS) patients into different upgrading risk groups is important in exploiting more precise therapeutic options. Evaluation of estrogen receptor/progesterone receptor/human epidermal growth factor receptor 2 (ER/PR/HER2) status and axillary lymph node metastatic status for DCIS and their upgraded invasive counterparts can also provide diagnostic and therapeutic implications. We retrospectively studied 575 patients with first-time diagnosis of DCIS on biopsies, and followed up their final diagnosis, ER/PR/HER2 status, and axillary lymph node involvement on excisions. As a result, biopsy-diagnosed DCIS had an overall 19.1% risk to be upgraded on subsequent excisions, with 4.7% being upgraded to microinvasive carcinoma (pT1mi) and 14.4% to overt invasive carcinoma (⩾pT1a). Factors significantly associated with higher upgrading risk on multivariate analysis include biopsy guidance by ultrasound ( P <.001), DCIS with suspicious microinvasion ( P < .001), and DCIS diagnosed in left breast ( P = .026). DCIS diagnosed in younger patients (⩽40 years old) or DCIS with high nuclear grade showed higher upgrading risk only on univariate analysis. About 80% ER + /PR + and ER−/PR− DCIS remained the same ER/PR status after being upgraded, and ER + /PR −  DCIS had the highest risk (63.6%) of having HER2 amplification in upgraded invasive carcinoma. For upgraded DCIS, microinvasive carcinoma was more likely to have HER2 amplification (50%) than overt invasive carcinoma (29.5%). Besides, pure DCIS had a low risk of axillary lymph node macrometastasis (0.74%), while the risk increased in DCIS with microinvasion (4.4%) and was highest in overt invasive carcinoma (14.7%). The findings of this study are clinically relevant with respect to criteria that might be used in selecting patients for de-escalation trials.



1982 ◽  
Vol 1 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Edward J. Wilkinson ◽  
M. Joyce Rico ◽  
K. Kendall Pierson


2000 ◽  
Vol 24 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Manju L. Prasad ◽  
Michael P. Osborne ◽  
Dilip D. Giri ◽  
Syed A. Hoda


2018 ◽  
Vol 21 (2) ◽  
pp. 197 ◽  
Author(s):  
Milim Kim ◽  
Hyun Jeong Kim ◽  
Yul Ri Chung ◽  
Eunyoung Kang ◽  
Eun-Kyu Kim ◽  
...  


1969 ◽  
Vol 52 (5) ◽  
pp. 511-529 ◽  
Author(s):  
Alan B. P. Ng ◽  
James W. Reagan


1971 ◽  
Vol 110 (7) ◽  
pp. 984-989 ◽  
Author(s):  
John G. Boutselis ◽  
John C. Ullery ◽  
Lawrence Charme


1977 ◽  
Vol 32 (4) ◽  
pp. 250-253
Author(s):  
MILTON H. LEMAN ◽  
WILLIAM L. BENSON ◽  
ROBERT J. KURMAN ◽  
ROBERT C. PARK


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