scholarly journals Exploring Secrets of Nuclear Actin Involvement in the Regulation of Gene Transcription and Genome Organization

10.5772/35718 ◽  
2012 ◽  
Author(s):  
Yong Zhong ◽  
Cynthia Kanagaratham ◽  
Danuta Radzioch
Keyword(s):  
Gene Transcription ◽  
Genome Organization ◽  
Nuclear Actin

scholarly journals Nuclear actin dynamics in gene expression and genome organization

2020 ◽  
Vol 102 ◽  
pp. 105-112 ◽  
Author(s):  
Salla Kyheröinen ◽  
Maria K. Vartiainen
Keyword(s):  
Gene Expression ◽  
Genome Organization ◽  
Actin Dynamics ◽  
Nuclear Actin

Nuclear actin is involved in the regulation of CSF1 gene transcription in a chromatin required, BRG1 independent manner

2007 ◽  
Vol 102 (2) ◽  
pp. 403-411 ◽  
Author(s):  
Zhaoxia Song ◽  
Min Wang ◽  
Xiaoguang Wang ◽  
Xuefang Pan ◽  
Wenguang Liu ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Nuclear Actin ◽  
Independent Manner

scholarly journals The order of macrophage 4D genome coordinates gene transcription during differentiation and infection

2021 ◽  
Author(s):  
Gang Cao ◽  
Da Lin ◽  
Weize Xu ◽  
Ping Hong ◽  
Chengchao Wu ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Genome Organization ◽  
Target Genes ◽  
Three Dimensional ◽  
Drug Candidate ◽  
Genome Architecture ◽  
Chromatin Conformation ◽  
Chromatin Loop ◽  
Target Genome ◽  
Organizational Patterns

Abstract The highly organized three-dimensional genome is crucial for gene transcription. However, it remains elusive how the order of the genome architecture related to its function. Here, we developed a single-cell Hi-C method and proposed TAD “degree of disorder” as a measure of genome organizational patterns, which is correlated with the chromatin epigenetic states, gene expression and co-regulation, and chromatin structure variability in individual cells. Upon Mycobacterium tuberculosis infection, NF-κB enters into the nucleus, binds to the target genome regions and initiates systematic chromatin conformation reorganization. Furthermore, we identified a remote NF-κB enriched enhancer promotes the expression of PD-L1 through chromatin loop, which could be a potential anti-tuberculosis and even anti-tumor therapeutic target. The integrated Hi-C, eQTL, and GWAS analysis depicted the atlas of the long-range target genes of tuberculosis susceptible loci. Among which SNP rs1873613 is located in the anchor of a dynamic chromatin loop with LRRK2, whose inhibitor AdoCbl could be an anti-tuberculosis drug candidate. Our study provides comprehensive resources for the 4D genome of immunocytes and sheds insights into the genome organization order and the coordinated gene transcription.

Unpolymerized nuclear actin is involved in the activation of CSF-1 gene transcription

2004 ◽  
Vol 28 (7) ◽  
pp. 511-516 ◽  
Author(s):  
Z SONG
Keyword(s):  
Gene Transcription ◽  
Nuclear Actin

scholarly journals Nuclear Actin-Binding Proteins as Modulators of Gene Transcription

Traffic ◽  
2005 ◽  
Vol 6 (10) ◽  
pp. 847-857 ◽  
Author(s):  
Jan Gettemans ◽  
Katrien Van Impe ◽  
Veerle Delanote ◽  
Thomas Hubert ◽  
Joël Vandekerckhove ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Binding Proteins ◽  
Actin Binding ◽  
Nuclear Actin ◽  
Actin Binding Proteins

scholarly journals Nuclear Actin Extends, with No Contraction in Sight

2005 ◽  
Vol 16 (11) ◽  
pp. 5055-5060 ◽  
Author(s):  
Thoru Pederson ◽  
Ueli Aebi
Keyword(s):  
Gene Transcription ◽  
Nuclear Periphery ◽  
Structural Basis ◽  
Nuclear Pore ◽  
Nuclear Pore Complexes ◽  
Nuclear Actin ◽  
The Past ◽  
Eukaryotic Gene ◽  
The One ◽  
Pore Complexes

Within the past two years, actin has been implicated in eukaryotic gene transcription by all three classes of RNA polymerase. Moreover, within just the past year, actin has been identified as a constituent of filaments attached to the nuclear pore complexes and extending into the nucleus. This review summarizes these and other very recent advances in the nuclear actin field and emphasizes the key present issues. On the one hand, we are confronted with a body of evidence for a role of actin in gene transcription but with no known structural basis; on the other hand, there is now evidence for polymeric actin—not likely in the classical F-actin conformation—in the nuclear periphery with no known function. In addition, numerous proteins that interact with either G- or F-actin are increasingly being detected in the nucleus, suggesting that both monomeric and oligomeric or polymeric forms of actin are at play and raising the possibility that the equilibrium between them, perhaps differentially regulated at various intranuclear sites, may be a major determinant of nuclear function.

scholarly journals A Nuclear Actin Function Regulates Neuronal Motility by Serum Response Factor-Dependent Gene Transcription

2009 ◽  
Vol 29 (14) ◽  
pp. 4512-4518 ◽  
Author(s):  
S. Stern ◽  
E. Debre ◽  
C. Stritt ◽  
J. Berger ◽  
G. Posern ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Serum Response Factor ◽  
Response Factor ◽  
Nuclear Actin ◽  
Serum Response

scholarly journals Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

2020 ◽  
Author(s):  
Christine R. Keenan ◽  
Hannah D. Coughlan ◽  
Nadia Iannarella ◽  
Timothy M. Johanson ◽  
Wing Fuk Chan ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Genome Organization ◽  
Dimensional Space ◽  
Nuclear Periphery ◽  
Nuclear Lamina ◽  
Genome Organisation ◽  
Protein Coding ◽  
3 Dimensional ◽  
Protein Coding Genes ◽  
Highly Correlated

SummaryH3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes in differentiation and development. Here, we investigate the molecular consequences of heterochromatin loss in cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes that catalyse heterochromatic H3K9me3 deposition. Unexpectedly, we reveal a predominant repression of protein-coding genes in Suv39DKO cells, with these differentially expressed genes principally in euchromatic (DNaseI-accessible, H3K27ac-marked) rather than heterochromatic (H3K9me3-marked) regions. Examination of the 3D nucleome reveals that transcriptomic dysregulation occurs in euchromatic regions close to the nuclear periphery in 3-dimensional space. Moreover, this transcriptomic dysregulation is highly correlated with altered 3-dimensional genome organization in Suv39DKO cells. Together, our results suggest that the nuclear lamina-tethering of Suv39-dependent H3K9me3 domains provides an essential scaffold to support euchromatic genome organisation and the maintenance of gene transcription for healthy cellular function.

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of

Regulation of neuronal cholecystokinin gene transcription

2001 ◽  
Vol 61 (7) ◽  
pp. 61-67 ◽  
Author(s):  
Thomas V. O. Hansen ◽  
Finn C. Nielsen
Keyword(s):  
Gene Transcription
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