Couchsurfing with Bateson: An ecology of digital platforms

Digital platforms radically alter socio-economic and organizational patterns. In an ecological sense, they enable the rapid extension of tolerance limits by digitally scaling variables such as the availability of accommodation or labour. However, such maximization of specific variables in a complex ecology bears the danger of pathological runaway patterns. In our paper we draw on the work of Gregory Bateson to outline an analytical approach for the study of digital platforms as ecological phenomena, focussing on the effects of digitalization on the context in which platforms operate. To study such meta-patterns, we elaborate three interrelated concepts: stress, adaptation and budgets of flexibility. We exemplify these ideas through a longitudinal study of the early digital platform Couchsurfing and develop implications for our understanding of technology and organization.

The Influence of Organizational Culture, Competence and Motivation toward the Quality of Education Services in State High Schools in West Java Province

The phenomenon that is used as the object of research is the Quality of Education Services at State Senior High Schools in West Java Province. The research objectives are (1) to discuss the influence of organizational culture toward the quality of education services; (2) Discussing the influence of competence toward the quality of education services; (3) Discussing the influence of motivation toward the quality of education services; (4) Get a new concept from discussing the influence of Organizational Culture toward the Quality of Educational Services; (5) Get a new concept from the discussion of the influence of Competence toward the Quality of Education Services; (6) Get a new concept from the discussion of the influence of motivation toward the quality of education services. The research sample of 381 respondents was taken from a population of 54,150 people with the Krejcie sampling technique. Determination of 10 Research Informants using snow ball technique. Collecting data using Literature Study, Questionnaire, Interview and Observation. The data analysis technique used SEM Analysis and Descriptive Analysis which was developed using Observer Triangulation and ASOCA methods. The following research results:The magnitude of the influence of Organizational Culture toward the Quality of Education Services at State Senior High Schools in West Java Province reached 0.69, which is quite strong and significant. The magnitude of the influence of Competence toward the Quality of Education Services at State Senior High Schools in West Java Province reached 0.55, which is quite strong and significant. The magnitude of the influence of motivation toward the quality of education services at public high schools in West Java province reached 0.86, which is very strong and significant.The new concepts that can be compiled from the discussion of the influence of Organizational Culture, Competence and Motivation toward the Quality of Education Services at State Senior High Schools in West Java Province are (1) a new concept of School Organizational Patterns; (2) a new concept on the Characteristics of Responses of Education Providers and (3) a new concept on the Drive for Achievement.

Exploring Relations between Cloud Morphology, Cloud Phase, and Cloud Radiative Properties in Southern Ocean Stratocumulus Clouds

Marine stratocumuli are the most dominant cloud type by area coverage in the Southern Ocean (SO). They can be divided into different self-organized cellular morphological regimes known as open and closed mesoscale-cellular convec- tive (MCC) clouds. Open and closed cells are the two most frequent types of organizational regimes in the SO. Using the liDAR- raDAR (DARDAR) version 2 retrievals, we quantify 59 % of all MCC clouds in this region as mixed-phase clouds (MPCs) during a 4-year time period from 2007 to 2010. The net radiative effect of SO MCC clouds is governed by changes in cloud albedo. Both, cloud morphology and phase, have previously been shown to impact cloud albedo individually, but their interac- tions and their combined impact on cloud albedo remain unclear. Here, we investigate the relationships between cloud phase, organizational patterns, and their differences regarding their cloud radiative properties in the SO. The mixed-phase fraction, which is defined as the number of MPCs divided by the sum of MPC and supercooled liquid cloud (SLC) pixels, of all MCC clouds at a given cloud-top temperature (CTT) varies considerably between austral summer and winter. We further find that seasonal changes in cloud phase at a given CTT across all latitudes are largely independent of cloud morphology and are thus seemingly constrained by other external factors. Overall, our results show a stronger dependence of cloud phase on cloud-top height (CTH) than CTT for clouds below 2.5 km in altitude. Preconditioning through ice-phase processes in MPCs has been observed to accelerate individual closed to open cell transitions in extratropical stratocumuli. The hypothesis of preconditioning has been further substantiated in large-eddy simulations of open and closed MPCs. In this study, we do not find preconditioning to primarily impact climatological SO cloud mor- phology statistics. Meanwhile, in-cloud albedo analysis reveals stronger changes in open and closed cell albedo in SLCs than MPCs. In particular few optically thick (cloud optical thickness > 10) open cell stratocumuli are characterized as ice-free SLCs. Theses differences in in-cloud albedo are found to alter the cloud radiative effect in the SO by 12 W m−2 to 39 W m−2 depending on season and cloud phase.

The order of macrophage 4D genome coordinates gene transcription during differentiation and infection

The highly organized three-dimensional genome is crucial for gene transcription. However, it remains elusive how the order of the genome architecture related to its function. Here, we developed a single-cell Hi-C method and proposed TAD “degree of disorder” as a measure of genome organizational patterns, which is correlated with the chromatin epigenetic states, gene expression and co-regulation, and chromatin structure variability in individual cells. Upon Mycobacterium tuberculosis infection, NF-κB enters into the nucleus, binds to the target genome regions and initiates systematic chromatin conformation reorganization. Furthermore, we identified a remote NF-κB enriched enhancer promotes the expression of PD-L1 through chromatin loop, which could be a potential anti-tuberculosis and even anti-tumor therapeutic target. The integrated Hi-C, eQTL, and GWAS analysis depicted the atlas of the long-range target genes of tuberculosis susceptible loci. Among which SNP rs1873613 is located in the anchor of a dynamic chromatin loop with LRRK2, whose inhibitor AdoCbl could be an anti-tuberculosis drug candidate. Our study provides comprehensive resources for the 4D genome of immunocytes and sheds insights into the genome organization order and the coordinated gene transcription.

The Effect of the Belief System, Family Organizations and Family Communication on Covid-19 Prevention Behaviour: the Perspective of Family Resilience

Family resilience has a very important role, especially in dealing with prolonged problems or crises such as the COVID-19 pandemic. The absence of family resilience might result in family breakdown, decreased family function in decision making, and destroy values in family life. This study aims to determine the effect of belief system, organizational patterns, and family communication on COVID-19 prevention behaviour within the framework of family resilience. The study focuses on factors that most likely influence COVID-19 prevention behaviour. This research is a descriptive analytic study using a cross-sectional approach. A total of 100 respondents representing households in the Banten province filled out or an online a questionnaire using Google Form. In this study, the multivariate analysis used is multiple logistic regression. The analysis showed that the variables that had significant relationships with COVID-19 prevention behaviour were the belief system (p = 0.005), family organization (p = 0.008) and family communication (p = 0.001). The results of this study also show that the family communication is the most related variable with an odds ratio of 2694, which means that family communication has the greatest influence of 2-3 times of ?? in efforts to prevent COVID-19.

Comparative Repeat Profiling of Two Closely Related Conifers (Larix decidua and Larix kaempferi) Reveals High Genome Similarity With Only Few Fast-Evolving Satellite DNAs

In eukaryotic genomes, cycles of repeat expansion and removal lead to large-scale genomic changes and propel organisms forward in evolution. However, in conifers, active repeat removal is thought to be limited, leading to expansions of their genomes, mostly exceeding 10 giga base pairs. As a result, conifer genomes are largely littered with fragmented and decayed repeats. Here, we aim to investigate how the repeat landscapes of two related conifers have diverged, given the conifers’ accumulative genome evolution mode. For this, we applied low-coverage sequencing and read clustering to the genomes of European and Japanese larch, Larix decidua (Lamb.) Carrière and Larix kaempferi (Mill.), that arose from a common ancestor, but are now geographically isolated. We found that both Larix species harbored largely similar repeat landscapes, especially regarding the transposable element content. To pin down possible genomic changes, we focused on the repeat class with the fastest sequence turnover: satellite DNAs (satDNAs). Using comparative bioinformatics, Southern, and fluorescent in situ hybridization, we reveal the satDNAs’ organizational patterns, their abundances, and chromosomal locations. Four out of the five identified satDNAs are widespread in the Larix genus, with two even present in the more distantly related Pseudotsuga and Abies genera. Unexpectedly, the EulaSat3 family was restricted to L. decidua and absent from L. kaempferi, indicating its evolutionarily young age. Taken together, our results exemplify how the accumulative genome evolution of conifers may limit the overall divergence of repeats after speciation, producing only few repeat-induced genomic novelties.

СУТНІСНА ХАРАКТЕРИСТИКА ІНТЕГРАЦІЙНОЇ ВЗАЄМОДІЇ ЯК ПЕРЕДУМОВА ФОРМУВАННЯ ІНТЕГРОВАНИХ БІЗНЕС-СТРУКТУР

The article offers a comprehensive study on the essential characteristics of integrative interaction as a pattern for building integrated business structures. Based on a deepened understanding of an integration concept, it is argued that regardless of the scope of integration, this term could be considered twofold: either as an association, one way or another (often of equal single-profile business entities at the same level), or as an affiliation with a larger actor or with an existing association, sometimes its acquisition. In each case, integration is carried out to gain competitive advantages, obtain a particular benefit, and according to certain criteria. A literature review of the vast body of economic theories and approaches demonstrates that the integration concept is employed at all levels: local (refers to production processes within a single microeconomic unit); at a microlevel (within several business units); at the national level (within a certain state); at a mesolevel (within several border states); at a macrolevel (in a certain region), at a megalevel (within the global economic area). The in-depth-study of the essential characteristics of integrative interaction as a pattern for building integrated business structures allowed to consider integration as a polygamous category from the following perspectives: as an integration of individual units, activities, functions, elements; as a structural element of social development; as a management concept of cooperation; as a strategy and tactics of market behavior in competitive environment; as a strategy for integrating efforts, actions and opportunities; as forms of association (interaction) or as a system-based business unit; as a novel management approach; as a model for creating and developing integrated structures, implementation of innovative organizational patterns; as the process that leads towards a contingence state (launching, developing, evolving, strengthening of ties); as the processes of building and developing interaction, partnership and cooperation.

Psychoanalytic Theory

Although Freud’s key claims regarding unconscious processes are pervasive in psychoanalytic theory, psychoanalysis is not a singular unified system. Early originating frameworks have evolved to adapt to changing clinical practices. In Britain, Freud’s work was complicated by the work of Klein, and later by the British Object Relations school, and still later by the inclusion of empirical research from John Bowlby’s attachment theory. In France and Latin America, Lacan gained dominance; in the United States, early work in “ego psychology” was supplemented by Kohutian “self-psychology” and later by “relational psychoanalysis.” In the academy, the work of Slavoj Zizek, synthesizing Lacanian and Marxist theory, has had wide influence. All these perspectives offer different accounts of the legacies of the past in their impact on unconscious expression. Early applications of psychoanalysis to literature were concerned with the origins of creativity and the neurotic conditions of literary characters or authors. Subsequent interests have focused on the nature of literary language and the dynamics of readerly engagements. In the early 21st century, use of psychoanalysis as an analytic tool follows the model of a conversation. The goal is not to apply a theory to a text to illustrate a psychoanalytic truth but to tease out the “unsaid” of a text or set of texts. Psychoanalysis in literary engagements, as in clinical engagements, is not about establishing a truth; instead it is used in “dialogue” with another discourse to discover implicit or unacknowledged dimensions of that articulation. The diversity of psychoanalytic schools and concepts allows scholars to give attention to wide-ranging interests: to the grip of ideology on subject, to the unconscious thematics of authors, to the symptomatic conditions of culture. Popular subjects for the psychoanalytic study of literature or film are psychic conflict, suffering, anxiety, enjoyment, the uncanny, and the repressed. Following World War II, the Frankfurt school synthesized Freud with Marxist thought, laying out enduring parameters for the psychoanalytic study of social processes. Adorno and Horkheimer sought to understand totalitarian character and mass culture and explored literature as a response to ideological enlistment. Recent work by “the Lacanian Left” in political theory explores libidinal and affective dimensions of discourse. “Psychosocial studies” scholars in Britain utilize psychoanalytic principles to gain more complex information from interviews and social research designs. Contemporary work in neuropsychoanalysis develops empirical evidence to document psychoanalytic processes in the organizational patterns of the brain, particularly in the dynamics of dreaming, memory, and nonconscious behavior. All these newly emerging engagements with psychoanalytic thought offer opportunities for contemporary research.