scholarly journals Brain Energy Metabolism in Health and Disease

10.5772/36092 ◽  
2012 ◽  
Author(s):  
Felipe A. ◽  
Anbal I. ◽  
Mara Paz ◽  
Maite A.
Keyword(s):  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Health And Disease ◽  
Brain Energy

scholarly journals Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases

2017 ◽  
Vol 37 (6) ◽  
pp. 1927-1943 ◽  
Author(s):  
Gilles Bonvento ◽  
Julien Valette ◽  
Julien Flament ◽  
Fanny Mochel ◽  
Emmanuel Brouillet
Keyword(s):  
Energy Metabolism ◽  
Neurodegenerative Diseases ◽  
Defense Mechanisms ◽  
Cellular Heterogeneity ◽  
Brain Energy Metabolism ◽  
Cellular Processes ◽  
Self Defense ◽  
Health And Disease ◽  
The Brain ◽  
Brain Energy

Changes in energy metabolism are generally considered to play an important role in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Whether these changes are causal or simply a part of self-defense mechanisms is a matter of debate. Furthermore, energy defects have often been discussed solely in the context of their probable neuronal origin without considering the cellular heterogeneity of the brain. Recent data point towards the existence of a tri-cellular compartmentation of brain energy metabolism between neurons, astrocytes, and oligodendrocytes, each cell type having a distinctive metabolic profile. Still, the number of methods to follow energy metabolism in patients is extremely limited and existing clinical techniques are blind to most cellular processes. There is a need to better understand how brain energy metabolism is regulated in health and disease through experiments conducted at different scales in animal models to implement new methods in the clinical setting. The purpose of this review is to offer a brief overview of the broad spectrum of methodological approaches that have emerged in recent years to probe energy metabolism in more detail. We conclude that multi-modal neuroimaging is needed to follow non-cell autonomous energy metabolism dysregulation in neurodegenerative diseases.

scholarly journals Insulin Effects on Brain Energy Metabolism and the Related Hexokinase Distribution

1974 ◽  
Vol 249 (21) ◽  
pp. 6930-6935
Author(s):  
Harvey R. Knull ◽  
William F. Taylor ◽  
William W. Wells
Keyword(s):  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Brain Energy

scholarly journals Effects of chloramphenicol on brain energy metabolism using31P spectroscopy: influences on sleep-wake states in rat

2008 ◽  
Vol 106 (4) ◽  
pp. 1552-1562 ◽  
Author(s):  
Halima Chahboune ◽  
Rachid Mahdjoub ◽  
Pierre Desgoutte ◽  
Colette Rousset ◽  
André Briguet ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Brain Energy
Sign in / Sign up

Export Citation Format

Share Document