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Alzheimer’s disease is one of the most prevailing age-dependent neurodegenerative disease and the most common
cause of dementia. The pharmacological therapies available for the disease provide only symptomatic relief. Plants are being
extensively investigated for Alzheimer’s as they are relatively safer and cheaper. This review summarizes recent findings
suggesting anti-Alzheimer potential of the plants along with compounds or mechanisms responsible for their efficacy and
their therapeutic targets. The findings of recent studies revealed that the plants or the compounds isolated from them exhibit
mitigative potential in Alzheimer’s disease by targeting amyloid beta, tau protein, cholinergic pathways via various enzymes
like beta secretase, gamma secretase, acetylcholinesterase or receptors involved in these pathways. A number of putative
compounds revealed from these studies can be investigated further for the mitigation of Alzheimer’s disease.
Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention Target