Helicobacter pylori and Hematologic Diseases

The Korean Journal of Helicobacter and Upper Gastrointestinal Research ◽

10.7704/kjhugr.2019.0047 ◽

2020 ◽

Vol 20 (1) ◽

pp. 11-20

Author(s):

Sam Ryong Jee

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Childhood Leukemia ◽

World Health ◽

Deficiency Anemia ◽

Plasma Cell Dyscrasia ◽

Coagulation Disorder ◽

Hematologic Diseases ◽

H Pylori

Helicobacter pylori (H. pylori) is a Gram-negative spiral bacterium, classified as a group 1 carcinogen by the World Health Organization. H. pylori infection is a major cause of gastritis, gastric and duodenal ulcers, and gastric cancer. It is associated with the pathogenesis of several hematologic diseases. H. pylori eradication has been proven effective in gastric mucosa-associated lymphoid tissue lymphoma and primary immune thrombocytopenia. As H. pylori causes iron deficiency anemia via several mechanisms, some recent guidelines recommended its eradication from patients with iron deficiency anemia. There are discussions of other conditions that are not included in the international consensus and management guides on H. pylori, including monoclonal gammopathy, myelodysplastic syndrome, childhood leukemia, coagulation disorder, megaloblastic anemia, pernicious anemia, plasma cell dyscrasia, and Henoch-Schönlein purpura. Further studies are required to establish new strategies to improve the management of patients with an infection combined with a hematologic disease of controversial or peculiar association.

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The rod-to-coccoid body transformation in cultures of Helicobacter pylori

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160686 ◽

1990 ◽

Vol 48 (3) ◽

pp. 626-627

Author(s):

A. R. Crooker ◽

W. G. Kraft ◽

T. L. Beard ◽

M. C. Myers

Keyword(s):

Helicobacter Pylori ◽

Growth Cycle ◽

Negative Bacterium ◽

Body Formation ◽

Coccoid Form ◽

Spiral Form ◽

Prolonged Culture ◽

H Pylori ◽

Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

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