scholarly journals The Wound Healing Responses and Corneal Biomechanics after Keratorefractive Surgery

2019 ◽  
Author(s):  
Wenjing Wu ◽  
Yan Wang
Keyword(s):  
Wound Healing ◽  
Corneal Biomechanics ◽  
Keratorefractive Surgery

Corneal Wound Healing After Keratorefractive Procedures

2009 ◽  
Vol 03 (02) ◽  
pp. 64
Author(s):  
Irene C Kuo ◽  
Keyword(s):  
Wound Healing ◽  
Refractive Surgery ◽  
Epithelial Hyperplasia ◽  
Tissue Destruction ◽  
Tissue Remodelling ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
Healing Tissue ◽  
Keratorefractive Surgery ◽  
Laser Refractive Surgery

Research into corneal wound healing is gaining renewed interest with the increasing volume of keratorefractive procedures. Such research may help avoid the complication of ectasia after laser refractive surgery. There are three histopathological types of wound healing after keratorefractive surgery – whether laser refractive surgery, penetrating keratoplasty or radial keratotomy – and these are reviewed in this paper. They are hypercellular fibrotic stromal scar preceded by activated keratocytes, epithelial hyperplasia or hypertrophy and hypocellular primitive stromal scar. All can be identified with light, electron and immunofluorescence microscopy (or, with less detail, by confocal microscopy). A single procedure can manifest all three types of wound healing. Tissue destruction is part of tissue remodelling, but in successful procedures destruction cannot be uncontrolled or excessive. The elucidation of the signalling components remains an important area of research.

scholarly journals Wound Healing After Keratorefractive Surgery

Cornea ◽  
2012 ◽  
Vol 31 ◽  
pp. S9-S19 ◽  
Author(s):  
Dimitri T. Azar ◽  
Jin-Hong Chang ◽  
Kyu Yeon Han
Keyword(s):  
Wound Healing ◽  
Keratorefractive Surgery

Wound healing in response to keratorefractive surgery

1993 ◽  
Vol 38 (3) ◽  
pp. 289-302 ◽  
Author(s):  
Kerry K. Assil ◽  
Andrew J. Quantock
Keyword(s):  
Wound Healing ◽  
Keratorefractive Surgery

Biomechanical and Wound Healing Characteristics of Corneas After Excimer Laser Keratorefractive Surgery

2008 ◽  
Vol 24 (1) ◽  
pp. S90-S96 ◽  
Author(s):  
Daniel G Dawson ◽  
Hans E Grossniklaus ◽  
Henry F Edelhauser ◽  
Bernard E McCarey
Keyword(s):  
Wound Healing ◽  
Excimer Laser ◽  
Keratorefractive Surgery

Effects of storage and wound healing on corneal biomechanics

2002 ◽  
Author(s):  
J.C. Coleman ◽  
R.W. Beuerman ◽  
S. Kaufman ◽  
D.A. Rice
Keyword(s):  
Wound Healing ◽  
Corneal Biomechanics

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

Wound healing. The effects of topical antimicrobial agents

1979 ◽  
Vol 115 (11) ◽  
pp. 1311-1314 ◽  
Author(s):  
R. G. Geronemus
Keyword(s):  
Wound Healing ◽  
Antimicrobial Agents ◽  
Topical Antimicrobial

Impact of bevacizumab chemotherapy on craniotomy wound healing

2012 ◽  
Vol 2012 ◽  
pp. 188-190
Author(s):  
I. Yang
Keyword(s):  
Wound Healing
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