scholarly journals The Role of miRNAs in Idiopathic Pulmonary Fibrosis

2019 ◽  
Author(s):  
Koichi Takagi ◽  
Munekazu Yamakuchi ◽  
Teruto Hashiguchi ◽  
Hiromasa Inoue
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

Role of Wnt/PCP pathway on bronchial cell function in Idiopathic Pulmonary Fibrosis

Pneumologie ◽  
2011 ◽  
Vol 65 (12) ◽  
Author(s):  
S Barkha ◽  
M Gegg ◽  
H Lickert ◽  
M Königshoff
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cell Function

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth

scholarly journals The prognostic role of Gender-Age-Physiology system in idiopathic pulmonary fibrosis patients treated with pirfenidone

2019 ◽  
Vol 13 (3) ◽  
pp. 166-173 ◽  
Author(s):  
Sergio Harari ◽  
Antonella Caminati ◽  
Marco Confalonieri ◽  
Venerino Poletti ◽  
Carlo Vancheri ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Prognostic Role

scholarly journals The role of infection in the pathogenesis of idiopathic pulmonary fibrosis

2013 ◽  
Vol 22 (129) ◽  
pp. 376-381 ◽  
Author(s):  
P. L. Molyneaux ◽  
T. M. Maher
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

scholarly journals Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes

2013 ◽  
Vol 6 (1) ◽  
pp. 20 ◽  
Author(s):  
Deborah L Clarke ◽  
Alan M Carruthers ◽  
Tomas Mustelin ◽  
Lynne A Murray
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

Modern Concepts on the Role of Inflammation in Pulmonary Fibrosis

2011 ◽  
Vol 135 (6) ◽  
pp. 780-788 ◽  
Author(s):  
Robert J. Homer ◽  
Jack A. Elias ◽  
Chun Gun Lee ◽  
Erica Herzog
Keyword(s):  
Cell Death ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Therapeutic Intervention ◽  
Macrophage Polarization ◽  
Critical Evaluation ◽  
Clinical Context ◽  
Disease Biomarkers ◽  
Unpublished Research

Abstract Context.—Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at one time was thought to be a result of inflammation in the lung. Although some forms of pulmonary fibrosis may result from inflammation, idiopathic pulmonary fibrosis is currently thought to result from cell death primarily and inflammation secondarily. Objective.—To determine the role of inflammation in pulmonary fibrosis in light of our laboratory's published and unpublished research and published literature. Data Sources.—Review based on our laboratory's published and unpublished experimental data with relevant background and clinical context provided. Conclusions.—Although cell death is central to pulmonary fibrosis, the proper cytokine environment leading to macrophage polarization is also critical. Evaluation of this environment is promising both for the development of disease biomarkers and for targets for therapeutic intervention.

The role of cigarette smoking-derived pollutants in the risk of mortality in idiopathic pulmonary fibrosis

2021 ◽  
pp. 2101372
Author(s):  
Taro Yasuma ◽  
Corina N. D'Alessandro-Gabazza ◽  
Osamu Hataji ◽  
Tetsu Kobayashi ◽  
Esteban C Gabazza
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cigarette Smoking ◽  
Risk Of Mortality

scholarly journals Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

2021 ◽  
Vol 12 ◽  
Author(s):  
Chiel van Geffen ◽  
Astrid Deißler ◽  
Markus Quante ◽  
Harald Renz ◽  
Dominik Hartl ◽  
...  
Keyword(s):  
Immune System ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Immune Responses ◽  
Immune Cells ◽  
Current Knowledge ◽  
Suppressor Cells ◽  
Interstitial Lung Diseases ◽  
Stromal Stem Cells

The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies is expanding. Uncontrolled immune responses and unbalanced injury-inflammation-repair processes drive the initiation and progression of idiopathic pulmonary fibrosis. The regulatory immune system plays important roles in controlling pathogenic immune responses, regulating inflammation and modulating the transition of inflammation to fibrosis. This review aims to summarize and critically discuss the current knowledge on the potential role of regulatory immune cells, including mesenchymal stromal/stem cells, regulatory T cells, regulatory B cells, macrophages, dendritic cells and myeloid-derived suppressor cells in idiopathic pulmonary fibrosis. Furthermore, we review the emerging role of regulatory immune cells in anti-fibrotic therapy and lung transplantation. A comprehensive understanding of immune regulation could pave the way towards new therapeutic or preventive approaches in idiopathic pulmonary fibrosis.

The potential role of airways periostin in the clinical practice of patients affected by Idiopathic Pulmonary Fibrosis

2021 ◽  
Author(s):  
Giovanna Elisiana Carpagnano ◽  
Piera Soccio ◽  
Giulia Scioscia ◽  
Grazia Pia Palladino ◽  
Maria Pia Foschino Barbaro ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Potential Role
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