SeDeM-ODT Expert System: A Solution to Challenges in Characterization of Pharmaceutical Powders and Powdered Material

2020 ◽  
Author(s):  
Amjad Khan ◽  
Shabnam Nazir ◽  
Hamad S. Alyami ◽  
Aman Ullah
Keyword(s):  
Expert System ◽  
Powder Material ◽  
Material Characterization ◽  
Dosage Form ◽  
Powdered Material ◽  
Pharmaceutical Product ◽  
Pharmaceutical Product Development ◽  
Minimum Number ◽  
Tablet Preparation

In the field of pharmaceutical sciences, material characterization has been a focus of research as properties of the powder ingredients govern characteristics of the finished dosage form. It has been a tedious and time-consuming job to develop a correlation between the characteristics of powder material and final dosage form. Extensive experimentation is carried out at different stages of formulation development to optimize the final blend and produce a product fulfilling official requirements. Various approaches have been applied for the purpose with varying degree of applications. SeDeM-ODT expert system is a novel pre-formulation technique developed for characterization of powder material of varying nature. Experimental and quantitative determination of various parameters provides a basis for SeDeM-ODT expert system. The system predicts suitability of powder material (APIs and excipients) for tablet preparation by direct compression technology and disintegration behavior of the resultant dosage form. It provides a basis for selection of excipients, both quantitatively and qualitatively. The present study covers area of powder characterization at pre-formulation level of pharmaceutical product development. SeDeM-ODT expert system reduces lead time for pre-formulation studies and provides formulations with minimum number of excipients. SeDeM-ODT expert system has been successfully applied for material characterization (APIs and excipients) before processing and after processing.

Importance of Physicochemical Characterization of Nanoparticles in Pharmaceutical Product Development

2019 ◽  
pp. 369-400
Author(s):  
Nidhi Raval ◽  
Rahul Maheshwari ◽  
Dnyaneshwar Kalyane ◽  
Susanne R. Youngren-Ortiz ◽  
Mahavir B. Chougule ◽  
...  
Keyword(s):  
Product Development ◽  
Physicochemical Characterization ◽  
Pharmaceutical Product ◽  
Pharmaceutical Product Development

Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds

2017 ◽  
Vol 68 (8) ◽  
pp. 1895-1902
Author(s):  
Ioana Cristina Tita ◽  
Eleonora Marian ◽  
Bogdan Tita ◽  
Claudia Crina Toma ◽  
Laura Vicas
Keyword(s):  
Thermal Behaviour ◽  
Active Substance ◽  
Pharmaceutical Research ◽  
Pharmaceutical Product ◽  
Nitrogen Atmosphere ◽  
Pure Substance ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ft Ir

Thermal analysis is one of the most frequently used instrumental techniques in the pharmaceutical research, for the thermal characterization of different materials from solids to semi-solids, which are of pharmaceutical relevance. In this paper, simultaneous thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC) were used for characterization of the thermal behaviour of candesartan cilexetil � active substance (C-AS) under dynamic nitrogen atmosphere and nonisothermal conditions, in comparison with pharmaceutical product containing the corresponding active substance. It was observed that the commercial samples showed a different thermal profile than the standard sample, caused by the presence of excipients in the pharmaceutical product and to possible interaction of these with the active substance. The Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) were used as complementary techniques adequately implement and assist in interpretation of the thermal results. The main conclusion of this comparative study was that the TG/DTG and DSC curves, together with the FT-IR spectra, respectively X-ray difractograms constitute believe data for the discrimination between the pure substance and pharmaceutical forms.

scholarly journals Correlation of Global Quantities at Material Characterization of Pressure-Sensitive Materials Using Sharp Indentation Testing

Lubricants ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 29
Author(s):  
Carl F. O. Dahlberg ◽  
Jonas Faleskog ◽  
Per-Lennart Larsson
Keyword(s):  
Finite Element ◽  
Material Characterization ◽  
Pressure Sensitivity ◽  
Pressure Sensitive ◽  
The Mean ◽  
Sharp Indentation ◽  
Von Mises ◽  
Von Mises Plasticity ◽  
Hardness Values

Correlation of sharp indentation problems is examined theoretically and numerically. The analysis focuses on elastic-plastic pressure-sensitive materials and especially the case when the local plastic zone is so large that elastic effects on the mean contact pressure will be small or negligible as is the case for engineering metals and alloys. The results from the theoretical analysis indicate that the effect from pressure-sensitivity and plastic strain-hardening are separable at correlation of hardness values. This is confirmed using finite element methods and closed-form formulas are presented representing a pressure-sensitive counterpart to the Tabor formula at von Mises plasticity. The situation for the relative contact area is more complicated as also discussed.

Mechanical material characterization of photosensitive polymers

2013 ◽  
Vol 20 (10-11) ◽  
pp. 1975-1979 ◽  
Author(s):  
J. Vogel ◽  
H.-J. Feige ◽  
J. Saupe ◽  
S. Schubert ◽  
J. Grimm
Keyword(s):  
Material Characterization ◽  
Photosensitive Polymers

Synthesis and material characterization of amorphous and crystalline (α-) Al2O3via aerosol assisted chemical vapour deposition

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 102956-102960 ◽  
Author(s):  
Sapna D. Ponja ◽  
Ivan P. Parkin ◽  
Claire J. Carmalt
Keyword(s):  
Chemical Vapour Deposition ◽  
Material Characterization ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Facile Synthesis ◽  
Quartz Substrates

The facile synthesis of Al2O3 in the amorphous and corundum phase on glass and quartz substrates, respectively, is reported.

Incompressibility and mesh sensitivity analysis in finite element simulation of rubbers

2016 ◽  
Vol 7 (1) ◽  
pp. 7-12 ◽  
Author(s):  
D. Huri
Keyword(s):  
Finite Element ◽  
Material Characterization ◽  
Numerical Stability ◽  
Material Parameters ◽  
Linear Finite Element ◽  
Element Simulation ◽  
Finite Element Calculations ◽  
Mesh Density ◽  
Rubber Component

Non-linear finite element calculations are indispensable when important information of the material response under load of a rubber component is desired. Although the material characterization of a rubber component is a demanding engineering task, the changing contact range between the parts and the incompressibility behaviour of the rubber further increase the complexity of the investigations. In this paper the effects of the choice of the numerical material parameters (e.g. bulk modulus) are examined with regard to numerical stability, mesh density and calculation accuracy. As an example, a rubber spring is chosen where contact problem is also handled.

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