scholarly journals Red Blood Cell Dynamics: The Contribution of Microgravity in the BIOMICS Project

Author(s):  
Thomas Podgorski ◽  
Gwennou Coupier ◽  
Christophe Minetti

Soft Matter ◽  
2020 ◽  
Vol 16 (26) ◽  
pp. 6191-6205 ◽  
Author(s):  
Fabio Guglietta ◽  
Marek Behr ◽  
Luca Biferale ◽  
Giacomo Falcucci ◽  
Mauro Sbragaglia

Computational Fluid Dynamics is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of RBCs at the mesoscale.



2008 ◽  
Vol 41 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Gabriel Popescu ◽  
YoungKeun Park ◽  
Wonshik Choi ◽  
Ramachandra R. Dasari ◽  
Michael S. Feld ◽  
...  




Soft Matter ◽  
2021 ◽  
Author(s):  
Abhilash Reddy Malipeddi ◽  
Kausik Sarkar

Hydrodynamic interactions generate a diffusive motion in particulates in a shear flow, which plays seminal roles in overall particulate rheology and its microstructure. Here we investigate the shear induced diffusion...



2006 ◽  
Vol 39 ◽  
pp. S332 ◽  
Author(s):  
M. Abkarian ◽  
M. Faivre ◽  
H.A. Stone


2022 ◽  
Vol 66 (9-10) ◽  
pp. 30-38
Author(s):  
N. M. Krasnova ◽  
S. G. Efremenko ◽  
N. E. Evdokimova ◽  
O. I. Filippova ◽  
Y. V. Chertovskikh ◽  
...  

Background. Individual sensitivity to isoniazid in tuberculosis patients is determined by the presence of N-acetyltransferase 2 (NAT2) enzyme gene allelic variants in genome. Evaluation of quantitative and qualitative alterations in peripheral blood can be used for diagnosis, disease severity estimation, or as a clue for estimation of anti-tuberculosis chemotherapy effectiveness and safety.Aim: Find associations between acetylation type and peripheral red blood cell (RBC) dynamics; determine the effect of NAT2 acetylation rate on the effectiveness and safety of treatment in patients with newly identified pulmonary tuberculosis (TB) residing in the Sakha Republic (Yakutia).Methods. This study included 146 patients with various clinical forms of newly diagnosed pulmonary TB. Oral isoniazid, rifampicin, pyrazinamide, and ethambutol were administered patients. Genotyping was performed via real time PCR.Results. Rapid and intermediate acetylators showed an increase in hemoglobin concentrations and RBC erythrocyte hemoglobin content by the end of chemotherapy (P<0.05). Incidence of anemia was lower in intermediate acetylators, compared to rapid or slow acetylators (P=0.013). Negative correlation was established between absolute RBC count and slow acetylation type (P=0.017). Patients with rapid acetylation type showed increased RBC distribution width indexes RDW-CV and RDW-SD (P<0.05).Conclusions. An adequate therapeutic effect was achieved with standard doses of anti-TB medications in patients with intermediate acetylation type. Rapid and slow acetylators required anti-TB medication dose correction. Genotyping for NAT2 gene in patients with pulmonary TB enables clinicians to choose the optimal dose of anti-TB medications, specifically, isoniazid dose.



Author(s):  
YongKeun Park ◽  
Catherine A. Best ◽  
Gabriel Popescu


1992 ◽  
Vol 188 (3) ◽  
pp. 1003-1009 ◽  
Author(s):  
Nadav Zamir ◽  
Shmuel Tuvia ◽  
Rivka Riven-Kreitman ◽  
Shlomo Levin ◽  
Rafi Korenstein


1992 ◽  
Vol 44 (2) ◽  
pp. 214-225 ◽  
Author(s):  
Christopher G. Ellis ◽  
Mary L. Ellsworth ◽  
Roland N. Pittman ◽  
Wayne L. Burgess


2020 ◽  
Vol 127 ◽  
pp. 105943 ◽  
Author(s):  
Martín A. Toderi ◽  
Bibiana D. Riquelme ◽  
Gustavo E. Galizzi


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