Sentinel Lymph Node Biopsy for Early Oral Cavity Squamous Cell Carcinoma

Oral Cavity ◽

Cell Carcinoma ◽

Neck Dissection ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Elective Neck Dissection

Early stage oral cavity squamous cell carcinoma (OCSCC) has a significant risk of subclinical nodal metastases, which is the strongest independent prognostic factor for regional recurrence and survival. However current preoperative imaging modalities are unable to identify patients with micrometastases, and an observation strategy has been associated with inferior outcomes when compared to an elective neck dissection. Sentinel lymph node biopsy provides a safe and accurate staging procedure to select the patients who benefit from an elective neck dissection, while avoiding unnecessary surgery in the patients who are node negative. There is recent Level II evidence demonstrating equivalent oncological outcomes when compared with elective neck dissection. However, a multidisciplinary approach is required including reliable mapping of the sentinel lymph node, precise surgical technique and comprehensive histopathological analysis to ensure accurate results are obtained.

Faculty Opinions recommendation of Sentinel lymph node biopsy or elective neck dissection for patients with oral squamous cell carcinoma?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1091400.545842 ◽

2007 ◽

Author(s):

Giulio Cantu

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Neck Dissection ◽

Lymph Node Biopsy ◽

Elective Neck Dissection ◽

The Role of Sentinel Lymph Node Biopsy in Oral Cavity Squamous Cell Carcinoma

The American Surgeon ◽

10.1177/000313481908501114 ◽

2019 ◽

Vol 85 (11) ◽

pp. 549-552

Author(s):

Anna Lazutkin ◽

Ron Eliashar ◽

Jawad Abu-Tair ◽

Jeffrey M. Weinberger ◽

Nir Hirshoren

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Sentinel lymph node biopsy or elective neck dissection for patients with oral squamous cell carcinoma?

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-007-0465-z ◽

2007 ◽

Vol 265 (S1) ◽

pp. 13-17 ◽

Cited By ~ 13

Author(s):

Harri Keski-Säntti ◽

Risto Kontio ◽

Jyrki Törnwall ◽

Ilmo Leivo ◽

Sorjo Mätzke ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Neck Dissection ◽

Lymph Node Biopsy ◽

Elective Neck Dissection ◽

Reliability of sentinel lymph node biopsy with squamous cell carcinoma of the oral cavity

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2004.08.014 ◽

2005 ◽

Vol 99 (5) ◽

pp. 532-538 ◽

Cited By ~ 14

Author(s):

Tsutomu Minamikawa ◽

Masahiro Umeda ◽

Takahide Komori

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Commentary on “Reliability of sentinel lymph node biopsy with squamous cell carcinoma of the oral cavity”

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2004.10.016 ◽

2005 ◽

Vol 99 (5) ◽

pp. 539-541 ◽

Cited By ~ 2

Author(s):

Remy H. Blanchaert ◽

D. Lee Morris

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Sentinel lymph node biopsy as an alternative to wait and see policy in patients with small T1 oral cavity squamous cell carcinoma

Acta Oto-Laryngologica ◽

10.1080/00016480701362002 ◽

2008 ◽

Vol 128 (1) ◽

pp. 98-102 ◽

Cited By ~ 13

Author(s):

>Harri Keski-säntti ◽

Risto Kontio ◽

Ilmo Leivo ◽

Jyrki Törnwall ◽

Sorjo Mätzke ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Node Biopsy ◽

Wait And See

Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx

The Journal of Laryngology & Otology ◽

10.1017/s0022215108003514 ◽

2008 ◽

Vol 123 (4) ◽

pp. 439-443 ◽

Cited By ~ 8

Author(s):

P Burns ◽

A Foster ◽

P Walshe ◽

T O'Dwyer

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Node Negative

AbstractObjectives:Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma.Design:We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative.Results:A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease.Conclusion:In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.