scholarly journals Small Vessel Transient Ischemic Attack and Lacunar Infarction Detected with Perfusion-Weighted MRI

2017 ◽  
Vol 19 (3) ◽  
pp. 365-366 ◽  
Author(s):  
Hyun-Wook Nah

2012 ◽  
Vol 14 (3) ◽  
pp. 160
Author(s):  
Sang-Don Han ◽  
Yoon-Sik Jo ◽  
Ick Hee Kim ◽  
Jin Yong Choi


Stroke ◽  
2017 ◽  
Vol 48 (9) ◽  
pp. 2361-2367 ◽  
Author(s):  
Vincent Thijs ◽  
Ulrike Grittner ◽  
Franz Fazekas ◽  
Dominick J.H. McCabe ◽  
Anne-Katrin Giese ◽  
...  


Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Tomoyuki Ohara ◽  
Toshiyuki Uehara ◽  
Rieko Suzuki ◽  
Shoichiro Sato ◽  
Mikito Hayakawa ◽  
...  


2019 ◽  
Vol 14 (9) ◽  
pp. 871-877 ◽  
Author(s):  
Tomoyuki Ohara ◽  
Toshiyuki Uehara ◽  
Shoichiro Sato ◽  
Mikito Hayakawa ◽  
Kazumi Kimura ◽  
...  

Background Recent prospective registration studies of transient ischemic attack in Western countries demonstrated that large artery atherosclerosis is the highest risk etiology for early stroke recurrence under urgent evaluation and treatment. On the other hand, some limited transient ischemic attack studies from East Asian countries showed transient ischemic attack patients due to small vessel occlusion were at a higher early stroke risk. Aims We aimed to assess the risk for early stroke in small vessel occlusion-transient ischemic attack patients in a Japanese large transient ischemic attack registry. Methods We analyzed the data of a prospective Japanese transient ischemic attack registry including 1320 transient ischemic attack patients within seven days after onset. Small vessel occlusion-transient ischemic attack was defined as the presence of lacunar transient ischemic attack syndrome, without other etiologies. The outcome measure was recurrent stroke within 30 days after transient ischemic attack. The predictors of 30-day recurrent stroke were estimated using the Cox proportional hazards model. Results The study population had a mean age of 69 ± 12 years and 470 were women. Recurrent stroke was observed in 61 patients (4.6%), and the highest rate was observed with small vessel occlusion-transient ischemic attack (7.8%), followed by large artery atherosclerosis (5.4%). In multivariate analysis, recurrent stroke was independently associated with small vessel occlusion-transient ischemic attack (hazard ratio (HR): 2.01, 95% confidence interval (CI): 1.19–3.35), higher systolic blood pressure (HR: 1.18, 95% CI: 1.08–1.28), and presentation within 3 h after onset (HR: 2.21, 95% CI: 1.27–4.04). Furthermore, small vessel occlusion-transient ischemic attack with acute small deep infarct on diffusion-weighted imaging was a stronger predictor of recurrent stroke (HR: 4.87, 95% CI: 2.09–10.0). Conclusion Small vessel occlusion-transient ischemic attack, especially with acute small deep infarct, had a higher early stroke risk compared with other etiologies in Japanese transient ischemic attack patients who received early management.



2016 ◽  
Vol 22 ◽  
pp. 447-453 ◽  
Author(s):  
Ying Li ◽  
Nan Liu ◽  
Yonghua Huang ◽  
Wei Wei ◽  
Fei Chen ◽  
...  


Stroke ◽  
2020 ◽  
Vol 51 (2) ◽  
pp. 655-658 ◽  
Author(s):  
Eiko Higuchi ◽  
Sono Toi ◽  
Yuka Shirai ◽  
Takao Hoshino ◽  
Kentaro Ishizuka ◽  
...  

Background and Purpose— Embolic stroke of undetermined source (ESUS) has been proposed to cause thromboembolic infarction from unknown but potential embolic sources. However, an embolus remains undetected in ESUS. The goal of this study was to characterize the prevalence and risk factors of microembolic signals (MESs) in ESUS. Methods— We examined 108 patients with acute ischemic stroke in the internal carotid artery territory or transient ischemic attack within 14 days of symptom onset and who were admitted to our hospital between April 2017 and March 2019. MESs were monitored in the middle cerebral artery on transcranial Doppler for 60 minutes. We examined the prevalence and number of MES in ESUS and other stroke subtypes, such as cardioembolism, large artery atherosclerosis, cerebral small vessel disease, and transient ischemic attack. The present study was registered in University Hospital Medical Information Network Clinical Trials Registry (UMIN000031913). Results— MESs were detected in 33 (31%) of 108 patients. ESUS showed the highest proportion (12/24 [50%]), followed by large artery atherosclerosis (8/20 [40%]), cardioembolism (6/18 [33%]), transient ischemic attack (4/24 [17%]), and cerebral small vessel disease (3/21 [14%]). Univariate analysis showed that higher systolic blood pressure, body mass index, hemoglobin A1c, and ESUS were significantly associated with MES. In multiple logistic regression analysis, ESUS remained significantly associated with MES after adjustment for described covariates from univariate analysis (odds ratio, 2.86 [95% CI, 1.01–8.08]). Conclusions— This study demonstrated significant association of ESUS with MES, supporting the embolic nature of this stroke subtype. Registration— URL: https://upload.umin.ac.jp . Unique identifier: UMIN000031913.



Stroke ◽  
2018 ◽  
Vol 49 (9) ◽  
pp. 2053-2060 ◽  
Author(s):  
Kui Kai Lau ◽  
Linxin Li ◽  
Michela Simoni ◽  
Ziyah Mehta ◽  
Wilhelm Küker ◽  
...  


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