Malignancies Arising in Oncocytic Schneiderian Papillomas

2001 ◽  
Vol 125 (10) ◽  
pp. 1365-1367 ◽  
Author(s):  
Anirban Maitra ◽  
Leland B. Baskin ◽  
Edward L. Lee
Keyword(s):  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Small Cell Carcinoma ◽  
Medical Literature ◽  
Benign Neoplasm ◽  
Undifferentiated Carcinoma ◽  
Small Cell ◽  
Benign Neoplasms ◽  
Sinonasal Undifferentiated Carcinoma

Abstract Oncocytic schneiderian papillomas (OSPs) are uncommon benign neoplasms that arise from the sinonasal schneiderian epithelium. Malignancies arising in OSPs are rare, and, to our knowledge, only 14 such instances have been reported in the medical literature. We report 2 additional cases—a small cell carcinoma and a sinonasal undifferentiated carcinoma arising in OSPs and presenting synchronously with the benign neoplasm. The potential for malignant transformation in OSPs is small, but warrants that these papillomas be completely excised to exclude a coexisting carcinoma.

scholarly journals Primary Small Cell Carcinoma of the Vagina

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Rafael Oliveira ◽  
Mayra Coelho Bócoli ◽  
João Carlos Saldanha ◽  
Eddie Fernando Candido Murta ◽  
Rosekeila Simões Nomelini
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Distant Metastases ◽  
Complete Response ◽  
Undifferentiated Carcinoma ◽  
Vaginal Wall ◽  
Small Cell ◽  
Complete Regression ◽  
Small Cell Undifferentiated Carcinoma ◽  
Upper Third

The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetative and necrotic lesion in left vaginal wall, in middle and upper third, and involvement of parametrium in its proximal third and medium third. A biopsy showed a small cell undifferentiated carcinoma composed of epithelial cells with round nuclei, oval or elongated, hyperchromatic nuclei, with little distinct nucleoli, and scarce cytoplasm. Immunohistochemistry showed positivity for AE1/AE3, CD57, and chromogranin A. The patient received 6 cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after 5 months of followup.

scholarly journals A pure microcytic bladder carcinoma synchronous to prostatic adenocarcinoma

Rare Tumors ◽  
2011 ◽  
Vol 3 (3) ◽  
pp. 95-97
Author(s):  
Vasileios Sakalis ◽  
Anastasia Gkotsi ◽  
Efrosyni Mylonaki ◽  
Aphroditi Pantzaki ◽  
Stavros Charalambous ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Medical Literature ◽  
Recent Literature ◽  
Bladder Tumour ◽  
Local Relapse ◽  
Small Cell ◽  
Prostatic Adenocarcinoma ◽  
Bladder Tumors ◽  
Luteinizing Hormone Releasing Hormone

Small cell carcinoma (SCC) or microcytic carcinoma of the urinary bladder is a rare entity comprising approximately 0.5% of all bladder tumors. Due to its rarity, no prospective studies evaluating the most effective treatment have been published in the medical literature. Several cases of bladder SCC have been presented so far. We describe our case report and we revise the recent literature. Our patient was diagnosed with pure bladder SCC and prostatic adenocarcinoma. After the initial and complete transurethral resection of the bladder tumour (TUR-BT), he underwent a thorax and mediastinum computer tomography (CT) examination to exclude primary pulmonary small cell carcinoma and a bone scan scintigraphy for staging purposes. He received a three 14-day cycles of Cisplatin-containing chemotherapeutic schema and a single dose of Luteinizing-Hormone Releasing hormone (LHRH) analogue injection after 14 days of bicalutamide administration. The patient is followed for 24 months without any signs of bladder SCC recurrence or biochemical or local relapse from prostatic adenocarcinoma.

Malignant transformation of ovarian mature cystic teratoma with a predominant pulmonary type small cell carcinoma component

2012 ◽  
Vol 62 (4) ◽  
pp. 276-280 ◽  
Author(s):  
Hayato Ikota ◽  
Kou Kaneko ◽  
Sachio Takahashi ◽  
Mitsue Kawarai ◽  
Yuko Tanaka ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Small Cell Carcinoma ◽  
Cystic Teratoma ◽  
Small Cell ◽  
Mature Cystic Teratoma

scholarly journals Respiratory papillomatosis with small cell carcinoma: case report and brief review

2020 ◽  
Vol 21 (6) ◽  
pp. 141-146
Author(s):  
Priya Sharma ◽  
◽  
Anish Jha ◽  
Bharath Janapati ◽  
Anil Jain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Small Cell Carcinoma ◽  
Relevant Literature ◽  
Recurrent Respiratory Papillomatosis ◽  
Small Cell ◽  
Rare Presentation ◽  
Dismal Prognosis ◽  
Prior Literature

Respiratory Papillomatosis is a rare disease in which multiple exophytic squamous wart-like lesions occur within the respiratory tract. Recurrent Respiratory Papillomatosis (RRP) has the potential for malignant transformation to squamous lung cell carcinoma with a dismal prognosis. Most of the prior literature has shown malignant transformation of respiratory papillomatosis into squamous cell carcinoma. Here, we report a rare presentation of respiratory papillomatosis coexisting with small cell carcinoma and a review of relevant literature.

scholarly journals Long-term follow-up of a Patient with Malignant Transformation of Inverted Papilloma into Sinonasal Undifferentiated Carcinoma

2017 ◽  
Vol 8 (3) ◽  
pp. ar.2017.8.0209 ◽  
Author(s):  
Carolyn A. Orgain ◽  
Terry Y. Shibuya ◽  
Lester D. Thompson ◽  
David B. Keschner ◽  
Rohit Garg ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Sinonasal Undifferentiated Carcinoma ◽  
Postnasal Drip ◽  
Nasal Tumors ◽  
History Of

Introduction Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5–4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5–15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC). Methods A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined. Results A 62-year-old man presented with a 3-month history of nasal airway obstruction, rhinorrhea, and postnasal drip refractory to medical therapy. He had a long history of exposure to fumes, chemicals, dusts, and solvents as a professional painter as well as a 45 pack-year history of smoking and alcohol abuse. The patient was ultimately found to have a left ethmoidal IP with a focus of malignant transformation into SNUC. Endoscopic resection was performed, followed by concurrent chemoradiation and adjuvant chemotherapy. After surgery, he had no evidence of recurrent disease after 9 years of follow-up. Conclusions IP is known to transform into squamous cell carcinoma. Here we report a rare case of malignant transformation into SNUC, a much more uncommon and aggressive lesion. Although traditionally associated with a poorer prognosis, the positive outcome for SNUC observed in this patient may potentially be attributed to early detection and timely therapeutic intervention.

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