Recurrent Amyloidoma of Soft Tissue With Exuberant Giant Cell Reaction

2003 ◽  
Vol 127 (12) ◽  
pp. 1609-1611 ◽  
Author(s):  
Sanjay Mukhopadhyay ◽  
Timothy A. Damron ◽  
Alfredo L. Valente
Keyword(s):  
Foreign Body ◽  
Soft Tissue ◽  
Giant Cell ◽  
Soft Tissues ◽  
Foreign Body Reaction ◽  
Chronic Osteomyelitis ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Cell Reaction ◽  
Instructive Case

Abstract Amyloidoma (localized tumorlike amyloidosis) in the soft tissues is rare. We present an instructive case of recurrent amyloidoma in the soft tissue of the ankle in a 45-year-old man with multiple surgical procedures and chronic osteomyelitis of the underlying bones. The lesion evaded diagnosis because of a florid giant cell reaction that led to various misdiagnoses, including giant cell tumor of tendon sheath, foreign body reaction secondary to surgery, and pseudogout. This case demonstrates the importance of considering the possibility of amyloidoma when a giant cell–rich lesion is encountered in the soft tissues.

scholarly journals Giant Cell Tumor of the Carotid Body: A Rare Tumor in a Novel Location

2019 ◽  
Vol 98 (3) ◽  
pp. 165-168
Author(s):  
Payal Chowdhary ◽  
Gabriel S. Makar ◽  
Thomas Holdbrook ◽  
Thomas C. Spalla
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Carotid Body ◽  
Soft Tissues ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Biological Behavior ◽  
Complete Excision ◽  
Tissue Equivalent

Primary giant cell tumor of soft tissue (GCT-ST) is a rare entity that is considered the soft tissue equivalent of giant cell tumor of bone. It most commonly arises in soft tissues of the trunk and extremities, with occurrence in the head and neck being extremely rare. We report a case of GCT-ST of the carotid body, the first report of a tumor of this kind arising from this site in the neck. Giant cell tumor of soft tissue is generally considered a benign tumor with low malignant potential; thus, surgical excision is usually curative. However, due to the location and invasive nature of this patient’s tumor, complete excision was not possible. We discuss the implication of this for long-term management of this patient, as well as similarities and differences in clinical presentation, histology, and biological behavior between this case and previously reported cases of GCT-ST.

scholarly journals Recurrence of Giant Cell Tumor of Posterior Tibialis Tendon

2017 ◽  
Vol 4 (1) ◽  
pp. 45-48
Author(s):  
Karan R Choudhry ◽  
Vishal N Mandlewala
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Asia Pacific ◽  
Tibialis Posterior ◽  
Medial Malleolus ◽  
Scar Mark

ABSTRACT Aim To present a case of recurrence of giant cell tumor of the tendon sheath (GCT TS) and its management. Background The GCT TS is a solitary benign soft tissue tumor of the limbs. It usually appears as an enlarging painless mass and has a synovial origin. The GCT TS is approximately 1.6% of all soft tissue tumors. The GCT TS of tibialis posterior is very rare, and recurrence has not been reported. Case report A 21-year-old male patient presents with complaint of swelling over right ankle since 3 years. Patient was operated for swelling 10 years back, and histological examination revealed GCT TS. Patient was asymptomatic for 3 years after operation and then developed swelling since last 3 years. On local examination, hypertrophic scar mark 1 × 4 cm was present at right medial malleolus. Ultrasonography of right medial malleolus and magnetic resonance imaging were done for further evaluation. Under spinal anesthesia and tourniquet control, medial approach was taken extending from 7 cm above the medial malleolus posterior to the tibia up to the talar head. Tissue was cleared and was sent for histopathology, which confirmed the diagnosis of GCT TS. Patient is on regular follow-up since then, and there has not been any recurrence. Conclusion Though rare, recurrence of GCT TS can occur, and it should be properly investigated and completely excised. Clinical significance Though recurrence of GCT TS is rarely reported, it needs to be dealt with a high index of suspicion and treated aggressively. How to cite this article Choudhry KR, Mandlewala VN. Recurrence of Giant Cell Tumor of Posterior Tibialis Tendon. J Foot Ankle Surg (Asia-Pacific) 2017;4(1):45-48.

Atypical Tenosynovial Giant Cell Tumor of the Foot and Ankle: A Case Report

2021 ◽  
Vol 111 (3) ◽  
Author(s):  
Peter Awad
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissue Tumor ◽  
Imaging Modality ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Tenosynovial Giant Cell Tumor ◽  
Tissue Tumor ◽  
Pathology Reports

Tenosynovial giant cell tumor, also known as giant cell tumor of the tendon sheath (GCT-TS), is a solitary, nodular, firm, benign, soft-tissue tumor that arises from the synovial lining of a tendon. The etiology is unknown. It is a rare soft-tissue tumor, with an overall incidence of one in 50,000 individuals, and usually affects people aged between 30 and 50 years. Magnetic resonance imaging tends to be the imaging modality of choice, used for surgical preparation. Widely accepted treatment involves local excision with or without radiotherapy. The author presents a case study involving a patient with an abnormally large, longstanding GCT-TS, diagnosed with clinical examination and imaging modalities, surgically excised, and further confirmed by pathology reports. Topic of discussion includes a review of GCT-TS.

Giant cell tumor of soft tissue originating from the thyroid: a case report and literature review

2020 ◽  
Author(s):  
Jianrong Chen ◽  
Haiyong Zhang ◽  
Xiufang Li ◽  
Mengjun Hu ◽  
Huan Lei ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissues ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
Case Presentation ◽  
Uncommon Neoplasm ◽  
Atypical Mitosis

Abstract Background: Giant cell tumor of soft tissues (GCT-ST) is a low malignant uncommon neoplasm, with is histological and immunophenotype similar to that of GCT of bone. Primary giant cell tumor of soft tissue arising in the thyroid is exceedingly rare. Case presentation: We reported a new case of GCT-ST originating from the thyroid occurring in 69-year-old woman. Histologically, the tumor was composed of two morphological components, mononuclear cells admixed with multinucleated osteoclast-like giant cells. Tumor is devoid of atypia, pleomorphism, and atypical mitosis. Immunohistochemically, the tumor cells showed strongly positivity with antibodies to CD68, but were negative for AE1/AE3, EMA and additional muscle markers. Conclusions: Due to its rare occurrence, we analyzed the clinical features of patients with primary thyroid GCT-ST to summarize some of our experiences and conduct a literature. The interest of this case lies in the rarity of this entity, the difficulty in preoperative diagnosis, and the confusion with other malignancies.

MULTIPLE LOCALIZED GIANT CELL TUMOR OF THE TENDON SHEATH (GCTTS) AFFECTING A SINGLE TENDON: A VERY RARE CASE REPORT AND REVIEW OF RECENT CASES

Hand Surgery ◽  
2011 ◽  
Vol 16 (03) ◽  
pp. 367-369 ◽  
Author(s):  
Talvinder Singh ◽  
Saqib Noor ◽  
Adrian W. Simons
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rare Case ◽  
Case Reports ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Giant Cell Tumors ◽  
Mri Scan ◽  
Tissue Mass

Introduction Giant cell tumors of the tendon sheath (GCTTS) are very common. More recently, a small number of case reports have identified the presence of multifocal GCTTS in the hand. These case reports have identified the presence of a maximum of two simultaneous lesions of a giant cell tumor affecting the same tendon sheath. We present an exceptionally rare case of simultaneous multiple localized GCTTS in which five lesions were identified on a single tendon simultaneously. This number of lesions on a single tendon has never been previously reported. Case: A 37-year-old tree surgeon initially complained of pain in the region of the base of the ring and little fingers. A month later, he developed multiple soft tissue swellings at these sites and a soft tissue mass in the center of the palm relating to the left ring finger. A magnetic resonance imaging (MRI) scan suggested multiple GCTTS. These masses were excised completely without MRI evidence of a recurrence. Multiple GCTTS should be a differential diagnosis of multiple soft tissue swellings in the hand with an MRI scan and complete excision being the appropriate imaging and treatment modality respectively.

scholarly journals Giant Cell Tumor of Tendon Sheath of Great Toe

2017 ◽  
Vol 15 (2) ◽  
pp. 62-64
Author(s):  
Surya Bahadur Thapa ◽  
Bibek Banskota ◽  
Ashok Kumar Banskota
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissue Tumor ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Great Toe ◽  
Extensor Hallucis Longus ◽  
Benign Soft Tissue Tumor ◽  
The Right

Introduction: Giant cell tumor of the tendon sheath is an uncommon benign soft tissue tumor of the tendon sheath and synovium usually affecting the middle aged population.  Only 3-10 % of Giant cell tumor of the tendon sheath occur on foot. Of them 5 - 10 % present with erosion of bone. We present a case of 30 years old male who had Giant cell tumor of the tendon sheath on the foot involving the Flexor Hallucis Longs  and Extensor Hallucis Longus and eroding both the phalanges of the right great toe.

Bilateral Mirror-Symmetrical Giant Cell Tumor of the Tendon Sheath in the Foot and Ankle: A Case Report

2021 ◽  
Vol 60 (1) ◽  
pp. 163-166
Author(s):  
Naji S. Madi ◽  
Said Saghieh ◽  
Ahmad Salah Naja ◽  
Rachid K. Haidar
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Foot And Ankle

scholarly journals Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy

2019 ◽  
Vol 72 (8) ◽  
pp. 550-553 ◽  
Author(s):  
Martin J Magers ◽  
Hristos Z Kaimakliotis ◽  
Marcelo P Barboza ◽  
Elhaam Bandali ◽  
Nabil Adra ◽  
...  
Keyword(s):  
Foreign Body ◽  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Giant Cell ◽  
Chronic Inflammation ◽  
Morphological Features ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Variant Histology

AimsTo describe a large tertiary care academic centre’s experience with patients who achieve a complete pathological response (ie, ypT0N0) following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) with emphasis on morphological features present in the RC and clinical outcome.Methods41 patients with ypT0N0 disease following transurethral resection of bladder tumour (TURBT), NAC and RC with available clinical follow-up information were analysed. Slides from all RCs were reviewed to confirm pathological stage and assess for morphological parameters (eg, foreign body giant cell reaction, dystrophic calcification, scar and fat necrosis).ResultsWith median follow-up of 32.8 months, the recurrence-free survival at 1 and 5 years was 97.4% and 93.5%, while the overall survival at 3 and 5 years was 94.2% and 88.6%, respectively. No patients died of urothelial carcinoma. Stage assigned at TURBT was 1 pTa (2%), 1 pT1 (2%), 38 pT2 (93%) and 1 pT3a (2%). 17 TURBTs demonstrated variant histology, with the majority of these being squamous (65%). The most common morphological features present at RC were scar (100%), foreign body giant cell reaction (80%), chronic inflammation within lamina propria (68%) and dystrophic calcifications (39%). Other morphological features were less common or absent.ConclusionypT0N0 disease at RC portends an excellent prognosis, regardless of stage or variant histology in the TURBT; scar, foreign body giant cell reaction, chronic inflammation and dystrophic calcifications are often present.

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