Diffuse Neuroendocrine Differentiation in a Morphologically Composite Mammary Infiltrating Ductal Carcinoma: A Case Report and Review of the Literature

2003 ◽  
Vol 127 (3) ◽  
pp. e131-e134 ◽  
Author(s):  
Odile David ◽  
Meena Bhattacharjee
Keyword(s):  
Ductal Carcinoma ◽  
Prognostic Significance ◽  
Neuroendocrine Differentiation ◽  
Electron Microscopic Examination ◽  
Breast Cancers ◽  
Review Of The Literature ◽  
Electron Microscopic ◽  
Infiltrating Ductal Carcinoma ◽  
Immunohistochemical Evidence

Abstract Neuroendocrine differentiation has been reported in both in situ and infiltrating breast cancers. The prognostic significance of neuroendocrine differentiation in mammary carcinoma is unclear. We report a case of infiltrating ductal carcinoma in which there was a morphologically conventional-appearing infiltrating ductal component admixed with nests of cells that resembled a carcinoid tumor and initially mimicked the appearance of intraductal carcinoma. Immunohistochemical stains for synaptophysin and chromogranin demonstrated diffuse, strong positivity uniformly throughout the tumor, even in the more conventional-appearing areas. Electron microscopic examination of tissue retrieved from paraffin blocks was attempted unsuccessfully. We concluded that this was an infiltrating ductal carcinoma with morphologic and immunohistochemical evidence of neuroendocrine differentiation. The case is discussed with a review of the literature and a discussion of nomenclature for tumors of the breast showing variable degrees of neuroendocrine differentiation.

Morphologic Study of Carcinoid-Like Tumors and Their Relation to True Carcinoids, Using Tumors of the Breast as a Model

1983 ◽  
Vol 69 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Faripour A. Forouhar
Keyword(s):  
Ductal Carcinoma ◽  
Secretory Granules ◽  
Lobular Carcinoma ◽  
Prognostic Significance ◽  
Electron Microscopic Examination ◽  
Carcinoid Tumors ◽  
Electron Microscopic ◽  
Microscopic Evaluation ◽  
Microscopic Studies ◽  
Membrane Bound

Two cases of an unusual type of infiltrating ductal carcinoma of the breast are presented. Both cases demonstrated a carcinoid-like pattern and were indistinguishable from carcinoid tumors of the breast by light microscopy. However, Grimelius stains and electron microscopic evaluation showed no evidence of membrane bound secretory granules. In regard to the prognostic significance and proper classification of carcinoids of the breast, awareness of carcinoid-like morphologic variants of infiltrating ductal or lobular carcinoma is important. It is also apparent that there is a spectrum of tumors which demonstrate some properties of true carcinoids, however, only the true carcinoids show a better prognosis and it serves no useful purpose to separate the rest of these tumors. The diagnosis of carcinoid tumors requires demonstration of secretory granules on electron microscopic examination or in special stains; conventional light microscopic studies alone are insufficient for this diagnosis. All these principles may be applied to carcinoid like tumors of other sites.

In Situ and Infiltrating Ductal Carcinoma Arising in a Breast Hamartoma

2000 ◽  
Vol 175 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Jolinda Mester ◽  
Rache M. Simmons ◽  
Madeline F. Vazquez ◽  
Ruth Rosenblatt
Keyword(s):  
Ductal Carcinoma ◽  
Infiltrating Ductal Carcinoma ◽  
Breast Hamartoma

scholarly journals Histopathology findings of non-mass cancers on breast ultrasound

2018 ◽  
Vol 7 (6) ◽  
pp. 205846011877495 ◽  
Author(s):  
Hye Rin Kim ◽  
Hae Kyoung Jung
Keyword(s):  
Ductal Carcinoma ◽  
Immunohistochemical Analysis ◽  
Breast Ultrasound ◽  
Her2 Overexpression ◽  
Tumor Type ◽  
Breast Cancers ◽  
Mammographic Finding ◽  
Minimal Invasion ◽  
Mass Lesions

Background There is little research done on non-mass cancers (NMCs) on breast ultrasound (US). Purpose To evaluate large-sectional histopathology findings of NMCs on breast US. Material and Methods The mammographic and histopathology features of biopsy proven 36 breast cancers which showed pure non-mass lesions on US were retrospectively reviewed. Results The most common mammographic finding was microcalcification (23/35, 65.7%); fine pleomorphic microcalcification was predominant (18/23, 78.3%). The main tumor type was pure ductal carcinoma in situ (DCIS) (14/36, 38.9%) and DCIS with micro- or minimal invasion (11/36, 30.6%). Among the 25 DCIS, histologic grade was high in 15 (60.0%) and intermediate in nine (36%); comedo necrosis was seen in 17 (68%). Immunohistochemical analysis was available in 27 lesions and showed HER2-overexpression in 12 (44.4%) and triple-negative in two (7.4%). Conclusion According to our limited patient sample, NMCs on breast US were mainly associated with high-grade DCIS.

Prognostic significance of Ki‐67 and topoisomerase IIα expression in infiltrating ductal carcinoma of the breast

1999 ◽  
Vol 55 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Pierre Rudolph ◽  
Gaëtan MacGrogan ◽  
Françoise Bonichon ◽  
Sven‐Olaf Frahm ◽  
Isabelle de Mascarel ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Prognostic Significance ◽  
Carcinoma Of The Breast ◽  
Topoisomerase Iiα ◽  
Ki 67 ◽  
Infiltrating Ductal Carcinoma

scholarly journals The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ

2019 ◽  
Vol 74 (7) ◽  
pp. 1025-1035 ◽  
Author(s):  
Michael S Toss ◽  
Islam M Miligy ◽  
Rita Haj‐Ahmad ◽  
Kylie L Gorringe ◽  
Abdulbaqi AlKawaz ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Prognostic Significance

scholarly journals Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Atif Ali Hashmi ◽  
Kashif Ali Hashmi ◽  
Muhammad Irfan ◽  
Saadia Mehmood Khan ◽  
Muhammad Muzzammil Edhi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Prognostic Significance ◽  
Breast Cancer Subtypes ◽  
Prognostic Parameters ◽  
Ki67 Index ◽  
Breast Cancers ◽  
Cancer Subtypes ◽  
Luminal B ◽  
Cancer Management

Abstract Objectives Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index. Cancer management should be according to loco-regional profile; therefore, we aimed to determine ki67 index in 1951 cases of intrinsic breast cancer subtypes and its association with other prognostic parameters in our set up. Results Triple negative breast cancers showed highest ki67 index (mean 50.9 ± 23.7%) followed by Her2neu (mean 42.6 ± 21.6%) and luminal B cancers (mean 34.9 ± 20.05%). Metaplastic and medullary breast cancers significantly showed higher ki67 index as compared to ductal carcinoma, NOS. No significant association of ki67 index was noted with any of the histologic parameters in different subtypes of breast cancer expect for tumor grade. Although, ki67 index is a valuable biomarker in breast cancer, however no independent prognostic significance of ki67 could be established in our study.

scholarly journals The prognostic significance of immune microenvironment in breast ductal carcinoma in situ

2020 ◽  
Vol 122 (10) ◽  
pp. 1496-1506 ◽  
Author(s):  
Michael S. Toss ◽  
Asima Abidi ◽  
Dorothea Lesche ◽  
Chitra Joseph ◽  
Sakshi Mahale ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Prognostic Significance ◽  
Immune Microenvironment

Counterpoint: Sentinel Lymph Node Biopsy Is Not Indicated for Ductal Carcinoma In Situ

2003 ◽  
Vol 1 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Stephen B. Edge ◽  
David G. Sheldon
Keyword(s):  
Lymph Node ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Prognostic Significance ◽  
Axillary Staging ◽  
High Survival ◽  
Axillary Surgery ◽  
Node Biopsy

The purpose of axillary surgery in breast cancer is to provide prognostic information to guide the choice of adjuvant systemic therapy. Axillary surgery for ductal carcinoma in situ (DCIS) was abandoned in the 1980s because of the extremely low risk of lymph node metastases and high survival rates. Most women with metastases probably harbored an unrecognized focus of invasion or had metastases subsequent to an invasive local recurrence. Increased use of the less morbid sentinel node biopsy (SNB) for axillary staging of invasive cancer and the recognition that many patients will harbor micrometastases in nodes only recognized by cytokeratin immunohistochemistry (IHC) led two groups to perform SNB with IHC in women with DCIS. One group included all subtypes of DCIS and found metastases in 13% (half of which were detected only on IHC). The other group studied only patients with “high-risk” DCIS. They found metastases in 12% (7 of 9 by IHC only). These groups recommend SNB for women with DCIS. However, the use of SNB in DCIS should be tempered by the uncertainty of the prognostic significance of IHC-detected metastases, the conflicting results of these 2 studies, and the real potential to cause more harm than good from the morbidity of the procedure, the application of unnecessary axillary dissection, and the use of unwarranted adjuvant systemic chemotherapy. These results should be used to generate hypotheses for clinical trials addressing these problems. However, SNB for DCIS remains investigational and should not be generally applied.

scholarly journals Ductal carcinoma in-situ arising within benign phyllodes tumours

2018 ◽  
Vol 100 (4) ◽  
pp. e97-e102 ◽  
Author(s):  
S-A Lui ◽  
HB Oh ◽  
S Wang ◽  
CW Chan
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Wide Local Excision ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Review Of The Literature ◽  
Breast Lump ◽  
Final Histology ◽  
Phyllodes Tumour ◽  
Phyllodes Tumours

Ductal carcinoma in situ arising within a benign phyllodes tumour is a rare neoplasm of the breast. We present a case of a 19-year-old woman who had a right breast lump for six months with the above diagnosis together with a mini-review of the literature. Ultrasound revealed a 5-cm breast lump and core biopsy revealed ductal carcinoma in situ. She underwent wide local excision of the breast lump with clear margins. Final histology confirmed ductal carcinoma in situ within a fibroepithelial lesion consistent with a benign phyllodes tumour. To our knowledge, this is the youngest case of ductal carcinoma in situ arising in a phyllodes tumour to have been reported so far.

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