Effect of neutral mutation on HIV-1 drug resistance in highly active antiretroviral therapy

2011 ◽  
Vol 6 (30) ◽  
Author(s):  
Guangyu HUANG
Intervirology ◽  
2014 ◽  
Vol 57 (5) ◽  
pp. 270-276 ◽  
Author(s):  
Guojian Li ◽  
Shujia Liang ◽  
Tim J. Harrison ◽  
Zhenzhu Tang ◽  
Zhiyong Shen ◽  
...  

2013 ◽  
Vol 14 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Quang Duy Pham ◽  
Thu Khanh Hoang Huynh ◽  
Tram Thu Luong ◽  
Ton Tran ◽  
Thinh Xuan Vu ◽  
...  

2013 ◽  
Vol 06 (03) ◽  
pp. 1350018 ◽  
Author(s):  
GUANGYU HUANG ◽  
AIJUN FAN ◽  
KAIFA WANG

To study the transition dynamics of resistant-type human immunodeficiency virus 1 (HIV-1) in highly active antiretroviral therapy (HAART) and the affect of neutral mutation in the evolution of HIV-1, a mathematical model is proposed when mutation occurs mainly during reproduction. The derived results show that the resistant-type will certainly colonize in patients once mutation occurs. Furthermore, a neutral mutation is closely related to the colonized pattern of resistant-type HIV-1 quasispecies and there are some changes in the pattern of transmission dynamics when mutation occurs mainly during reproduction or in the absence of reproduction, which may lead to significant strategies for predicting or checking HIV-1 drug resistance in HAART.


2008 ◽  
Vol 46 (10) ◽  
pp. 1589-1597 ◽  
Author(s):  
Vincent C. Marconi ◽  
Henry Sunpath ◽  
Zhigang Lu ◽  
Michelle Gordon ◽  
Kofi Koranteng‐Apeagyei ◽  
...  

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