scholarly journals Autologous platelet-rich plasma optimizes endometrial thickness and pregnancy outcomes in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles

2021 ◽  
Author(s):  
Yogita Dogra ◽  
Neeta Singh ◽  
Perumal Vanamail
Keyword(s):  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

scholarly journals Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT

2019 ◽  
Author(s):  
Leila Nazari ◽  
Saghar Salehpour ◽  
Sedighe Hoseini ◽  
Shahrzad Zadehmodarres ◽  
Eznoallah Azargashb
Keyword(s):  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Double Blind ◽  
Thin Endometrium ◽  
Catheter Group ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

Background: Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth. Objective: To assess the effectiveness of autologous platelet-rich plasma (PRP) intrauterine infusion for the treatment of thin endometrium. Materials and Methods: A total of 72 patients who had a history of cancelled frozen-thawed embryo transfer cycle due to the thin endometrium (< 7mm) were assessed for the eligibility to enter the study between 2016 and 2017. Twelve patients were excluded for different reasons, and 60 included patients were randomly assigned to PRP or sham-catheter groups in a double-blind manner. Hormone replacement therapy was administered for endometrial preparation in all participants. PRP intrauterine infusion or sham-catheter was performed on day 11-12 due to the thin endometrium and it was repeated after 48 hr if necessary. Results: Endometrial thickness increased at 48 hr after the first intervention in both groups. All participants needed second intervention due to an inadequate endometrial expansion. After second intervention, endometrial thickness was 7.21 ± 0.18 and 5.76 ± 0.97 mm in the PRP group and sham-catheter group, respectively. There was a significant difference between the two groups. (p < 0.001). Embryo transfer was done for all patients in PRP group and just in six cases in the sham-catheter group. Chemical pregnancy was reported in twelve cases in the PRP group and two cases in the sham-catheter group. Conclusion: According to this trial, PRP was effective in endometrial expansion in patients with refractory thin endometrium.

scholarly journals Effect of autologous platelet rich plasma on thin endometrium in frozen thawed embryo transfer

2020 ◽  
Vol 9 (3) ◽  
pp. 1079
Author(s):  
Adaboina Anitha ◽  
Burri Sandhya Rani
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Study Data ◽  
Thin Endometrium ◽  
History Of ◽  
Autologous Platelet Rich Plasma ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

Background: Endometrium is one of the main factors in implantation and pregnancy. Some of the assisted reproductive technology treatment (ART) cycles get cancelled due to inadequate endometrial growth. This study was conducted to evaluate the effectiveness of PRP (platelet rich plasma) in the treatment of thin endometrium and its outcome on pregnancy and live birth rates.Methods: This study was a prospective cohort which was conducted from January 2018 to December 2018 at Laxmi Narasimha Hospital, Warangal, Telangana State. 30 patients with history of inadequate endometrial growth in frozen thawed embryo transfer cycles were recruited into the study. Intrauterine infusion of PRP was performed. Endometrial thickness was assessed.Results: 30 women were recruited in the study data of the 24 women were collected. Live birth was seen in 5 patients in the week range of 37±to 37±5 and average EMT in mm was 7.8, abortion was seen in 3 patients in the week range of 6 to 8±2 and average EMT in mm was 7.4 , chemical pregnancy was seen in 2 patients in the week range of 6 and average EMT in mm was 7.2 and number of women who were not pregnant were 14 and average EMT in mm was 7.0. Live birth was observed in 21% of the patients, abortion was observed in 13%, chemical pregnancy was seen in 9% and women who were not pregnant were 58%.Conclusions: Ability of autologous PRP to restore the endometrial receptivity of damaged endometrium has some aspects other than increasing the EMT.

scholarly journals Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle

2019 ◽  
Vol 2 (2) ◽  
pp. 80-82
Author(s):  
Sara Mahmood ◽  
Salma Kafeel ◽  
Riffat Bibi ◽  
Naveed Iqbal
Keyword(s):  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Uterine Cavity ◽  
Blastocyst Stage ◽  
Frozen Embryo Transfer ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Endometrial Proliferation

Inadequate endometrial proliferation is a known cause of implantation failure in assisted reproductive technology cycles. It is generally agreed that >9 mm endometrial thickness is associated with higher implantation. Several strategies have been explored to enhance endometrial proliferation. However, the results are either poor, inconsistent or subject to safety concerns. A 34-year old woman presented with unexplained thin endometrium in successive frozen embryo transfer (FET) cycles. Autologous platelet-rich plasma (PRP) was infused in the uterine cavity on day 10 of second FET cycle enhancing endometrial thickness, which post-PRP infusion measured 10.9 mm. Blastocyst-stage embryos were transferred resulting in a successful pregnancy. Autologous intrauterine infusion of PRP positively impacts endometrial proliferation and implantation which is safe, low resource and minimally invasive.

Effectiveness of intrauterine administration of autologous platelet-rich plasma for the preparation of the "thin" endometrium for the program of defrosted embryo transfer

2021 ◽  
Vol 2_2021 ◽  
pp. 90-95
Author(s):  
Dzhincharadze L.G. Dzhincharadze ◽  
Abubakirov A.N. Abubakirov ◽  
Mishieva N.G. Mishieva ◽  
Bakuridze E.M. Bakuridze ◽  
Bystrykh O.A. Bystrykh ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet
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