A field experiment was conducted during rainy (kharif) season of 2016 at Crop Research centre Pusa, Bihar to investigate the “Effect of Moisture Regimes and Weed Management on quality of Direct Seeded Rice”. The treatments consisted of three moisture regimes in main plots and five weed management practices in sub plots. The results showed that grain (3.62 t/ha) and straw yields (52.44 q/ha), harvest index (40.83%), P uptake (10.97 kg/ha) by rice grain were maximum with 3 days Disappearance of Ponded Water(DPW) which were significantly superior to 5 and 7 DPW but N (42.19 kg/ha) and P uptake (10.97 kg/ha) by rice grain, N (30.53 kg/ha), P (8.41 kg/ha) and K (74.47 kg/ha) uptake by straw were statistically at par with 5 DPW. With regard to weed management grain yield(35.62 q/ha) was maximum with W4 treatment of weed management which was significantly superior to W2, W1 and W5 but was statistically at par with W3 treatment while, straw yield (45.12 q/ha), N(41.37 and 29.75 kg/ha), P(10.72 and 8.18 kg/ha) and K(8.80 and 7.58 kg/ha) uptake by rice grain and straw were significantly superior to W1 and W5 and were comparable to W3 and W2 treatments. In harvest index (40.97%), W4 treatment was significantly superior to all the treatments. N, P and K content in grain and straw did not vary significantly with varying moisture regimes weed management treatments.