scholarly journals Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment

2012 ◽  
Vol 2 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Anthony D. Sung ◽  
Nelson J. Chao
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Concise Review ◽  
Prevention And Treatment ◽  
Acute Graft

scholarly journals Acute graft-versus-host disease: a bench-to-bedside update

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Shernan G. Holtan ◽  
Marcelo Pasquini ◽  
Daniel J. Weisdorf
Keyword(s):  
Small Molecules ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Multiple Modalities ◽  
Graft Versus Host ◽  
The Past ◽  
Prevention And Treatment ◽  
Near Future ◽  
Acute Graft

Abstract Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.

scholarly journals α4β7 Blockade with Vedolizumab Is Effective in Prevention and Treatment of Experimental Acute Graft Versus Host Disease

2019 ◽  
Vol 25 (3) ◽  
pp. S300-S301
Author(s):  
Senthilnathan Palaniyandi ◽  
Reena Kumari ◽  
Ethan Strattan ◽  
Katharina Kohler ◽  
Jing Du ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Prevention And Treatment ◽  
Acute Graft
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