scholarly journals THE EFFECT OF LONG TERM ALKALI THERAPY FOR RECURRENT CALCIUM STONE PATIENTS WITH DISTAL RENAL TUBULAR ACIDOSIS

1993 ◽  
Vol 84 (4) ◽  
pp. 674-679
Author(s):  
Seiji Yamaguchi ◽  
Takuo Koide ◽  
Masato Utsunomiya ◽  
Toshiaki Yoshioka ◽  
Akihiko Okuyama
Keyword(s):  
Renal Tubular Acidosis ◽  
Distal Renal Tubular Acidosis ◽  
Calcium Stone ◽  
Alkali Therapy ◽  
Renal Tubular

scholarly journals Prospective long-term evaluation of incomplete distal renal tubular acidosis in idiopathic calcium nephrolithiasis diagnosed (treated) by low-dose NH4CL loading – gender prevalences and impact of alkali treatment

2022 ◽  
Author(s):  
Juri Sromicki ◽  
Georg Kacl ◽  
Malin Föhl ◽  
Bernhard Hess
Keyword(s):  
Calcium Phosphate ◽  
Renal Tubular Acidosis ◽  
Alkali Treatment ◽  
Distal Renal Tubular Acidosis ◽  
Urine Ph ◽  
Calcium Stone ◽  
Stone Formers ◽  
Alkali Therapy ◽  
Renal Tubular

Abstract Purpose Prospective evaluation of the prevalence of incomplete distal renal tubular acidosis (idRTA) in idiopathic calcium stone formers (ICSF) diagnosed by half-dose ammonium chloride loading (NH4Cl, 0.05 g/kg body weight/day) and impact of alkali treatment of idRTA. Methods Evaluation of 386 consecutive idiopathic calcium stone formers (ICSF) (280 males, 106 females) for idRTA. If screening fasting urine pH was > 5.80, 1-day NH4Cl loading was performed without severe adverse effects. Normally, urine pH falls below 5.45. Results Sixty-four idiopathic calcium stone formers exhibited idRTA, one complete dRTA. Prevalence was higher in women (25.4%) than in men (13.6%). Thus, for more equilibrated comparisons, we formed pairs of 62 idiopathic calcium stone formers (ICSF) with and 62 without idRTA, matched for gender, age, BMI and serum creatinine. Idiopathic calcium stone formers with idRTA more often had hypercalciuria (p < 0.025) and urine citrate < 2 mmol/d (p < 0.05), formed calcium phosphate stones more frequently, exhibited higher numbers of stones/year (1.4 ± 1.5 vs. 0.9 ± 0.8, p = 0.034) and 2.5 times more intrarenal calcifications (4.6 ± 5.9 vs. 1.8 ± 3.6, p = 0.002). All idiopathic calcium stone formers with idRTA were recommended chronic alkali therapy. After 4–15 years of follow-up, stone events /years follow-up (stone passage or urologic intervention) were higher in patients non-adherent to alkali therapy (0.61 ± 0.92) than in patients adherent to treatment (0.11 ± 0.21, p = 0.006). Conclusion Incomplete distal renal tubular acidosis is 1.8-fold more prevalent among female idiopathic calcium stone formers, predicts more stone recurrences, predisposes to calcium phosphate stones and is associated with 2.5 times more intrarenal calcifications vs. non-idRTA patients. Chronic alkali treatment reduces clinical stone recurrences by 5.5 times. Graphical abstract

scholarly journals Treatment and long-term outcome in primary distal renal tubular acidosis

2019 ◽  
Vol 34 (6) ◽  
pp. 981-991 ◽  
Author(s):  
Sergio Camilo Lopez-Garcia ◽  
Francesco Emma ◽  
Stephen B Walsh ◽  
Marc Fila ◽  
Nakysa Hooman ◽  
...  
Keyword(s):  
Renal Tubular Acidosis ◽  
Distal Renal Tubular Acidosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Renal Tubular

Molecular aspects and long-term outcome of patients with primary distal renal tubular acidosis

2021 ◽  
Author(s):  
Sara Gómez-Conde ◽  
Alejandro García-Castaño ◽  
Mireia Aguirre ◽  
María Herrero ◽  
Leire Gondra ◽  
...  
Keyword(s):  
Renal Tubular Acidosis ◽  
Distal Renal Tubular Acidosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Molecular Aspects ◽  
Renal Tubular

scholarly journals Hereditary distal renal tubular acidosis: Genotypic correlation, evolution to long term, and new therapeutic perspectives

2021 ◽  
Author(s):  
Sara Gómez-Conde ◽  
Alejandro García-Castaño ◽  
Mireia Aguirre ◽  
María Herrero ◽  
Leire Gondra ◽  
...  
Keyword(s):  
Renal Tubular Acidosis ◽  
Distal Renal Tubular Acidosis ◽  
Genotypic Correlation ◽  
Renal Tubular

scholarly journals Distal Renal Tubular Acidosis in Adolescence with Severe Growth Retardation and Nephrocalcinosis

2012 ◽  
Vol 52 (187) ◽  
Author(s):  
M R Sigdel ◽  
M P Kafle ◽  
K B Raut
Keyword(s):  
Metabolic Acidosis ◽  
Weight Gain ◽  
Renal Tubular Acidosis ◽  
Growth Retardation ◽  
Growth Velocity ◽  
Distal Renal Tubular Acidosis ◽  
Alkali Therapy ◽  
Renal Tubular ◽  
Severe Growth

Chronic acidosis is an important, often overlooked cause of growth retardation. Here we present the case of a girl with distal renal tubular acidosis who had visited multiple hospitals before the diagnosis was made. She presented to us in adolescence with non anion gap metabolic acidosis, hypokalemia, severe growth retardation and nephrocalcinosis. In 18 months follow up with alkali therapy, she had good weight gain and growth velocity. Keywords: growth retardation; hypokalemia; nephrocalcinosis; renal tubular acidosis.

scholarly journals Clinical, Paraclinical Characteristics in Children with Renal Tubular Acidosis

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Nguyen Thanh Tung ◽  
Nguyen Thu Huong ◽  
Pham Van Dem ◽  
Nguyen Thi Quynh Huong
Keyword(s):  
Renal Tubular Acidosis ◽  
Clinical Signs ◽  
Distal Renal Tubular Acidosis ◽  
Renal Tubules ◽  
Nephrol Dial Transplant ◽  
Long Term Outcome ◽  
Female Ratio ◽  
Arterial Blood ◽  
Renal Tubular

This descriptive study describes the clinical, paraclinical characteristics in children with renal tubular acidosis. In this study, 36 children with renal tubular acidosis were hospitalized in the National Hospital of Pediatrics from June, 2012 to July, 2017. Among the patients, 64.0% were male; the male/female ratio was 1.8/1. The average age of the patients was 7.7 ± 4.6 years. There were 29 type 1 renal tubular acidosis patients (80.6%) and 7 type 2 renal tubular acidosis (19.6%). The most common clinical signs were slow weight gain (100%), polyuria and vomiting were 25.7%, excessive water drinking (16.7%), diarrhea (13.9%), weak lower limb (11.1%), and apnea (8.3%). The laboratory values on admission were: blood pH 7.23 ± 0.11; HCO3- 12.5 ± 5.07; serum sodium 136 ± 7mmol/l; potassium 2.9 ± 0.5 mmol/l; chloride 112 ± 9 mmol/l. The study concludes that 53.8% of the clinical, paraclinical characteristics in children with Renal Tubular Acidosis were inconspicuousness, which effected the children’s growth. The study recommends a long-term strategy for diagnosis and follow–up treatment of renal tubular acidosis. Keywords Renal tubular acidosis, Fanconi syndrome. References [1] Edyta Golembiewska and Kazimierz Ciechanowski, Renal tubular acidosis—underrated problem?, Acta biochimica polonica. 59(2) (2012) 213-215.[2] WHO (2011), Haemoglobin concentrations for the diagnosis of annaemia and assessment of severity, VMNIS, 1.[3] A.P. Sharma, R.K. Sharma, R. Kapoor, et al, Incomplete distal renal tubular acidosis affects growth in children, Nephrol Dial Transplant. 22 (10) (2007) 2879-2783.[4] WHO Child Growth Standards: Methods and development, tại trang web http://www.who.int/childgrowth/standards/technical_report/en/, truy cập ngày 30/10/2018.[5] A. Bagga Bajpai, P. Hari, A. Bardia, et al, Long-term outcome in children with primary distal renal tubular acidosis, Indian Pediatr. 42(4) 321 -328.[6] J.C. Chan, F. Santos, Renal tubular acidosis in children, Diagnosiseatment and prognosis., Am J Nephrol. 6(4) (2005) 289-294.[7] Symptoma Renal Tubular Acidosisuy, tại trang web https://www.symptoma.com/en/info/renal-tubular-acidosis, truy cập ngày 30/10/2018.[8] Julian Yaxley, Christine Pirrone, Review of the Diagnostic Evaluation of Renal Tubular Acidosis, Ochsner J. 16(4) (2016) 525-232.[9] Pramod Sood, Gunchan Paul, and Sandeep Puril, Interpretation of arterial blood gas, Indian J Crit Care Med. 14(2) (2010) 57-63.[10] J.L. Wilson, A.M. Butler, S. Farber, Dehydration and acidosis with calcification at renal tubules, The Journal of Pediatrics. 8 (2006) 489-494.  

scholarly journals A Pediatric Case of Long-term Untreated Distal Renal Tubular Acidosis

2020 ◽  
Vol 24 (2) ◽  
pp. 115-119
Author(s):  
Philavanh Kedsatha ◽  
Hee Young Shin ◽  
Yong Choi ◽  
Hae Il Cheong ◽  
Tae-Joon Cho ◽  
...  
Keyword(s):  
Renal Tubular Acidosis ◽  
Distal Renal Tubular Acidosis ◽  
Pediatric Case ◽  
Renal Tubular

Distal Renal Tubular Acidosis Associated with Concurrent Leptospirosis in a Dog

2014 ◽  
Vol 50 (3) ◽  
pp. 203-208 ◽  
Author(s):  
Stephen A. Martinez ◽  
Roger A. Hostutler
Keyword(s):  
Metabolic Acidosis ◽  
Renal Tubular Acidosis ◽  
Clinical Signs ◽  
Distal Renal Tubular Acidosis ◽  
The Other ◽  
Laboratory Evaluation ◽  
Alkaline Urine ◽  
Alkali Therapy ◽  
Renal Tubular

A 9 yr old spayed female boxer was presented for evaluation of vomiting, lethargy, anorexia, and weight loss. Initial laboratory evaluation revealed a hyperchloremic normal anion gap metabolic acidosis with alkaline urine that was consistent with a diagnosis of distal renal tubular acidosis (RTA). Targeted therapy was initiated with Na bicarbonate (HCO3) and potassium (K) gluconate. Leptospirosis was subsequently diagnosed with paired microagglutination testing (MAT), and doxycycline was added to the other treatments. Clinical signs resolved, and 6 mo after diagnosis, although the dog remained on alkali therapy (i.e., NaHCO3 and K gluconate) and a mild metabolic acidosis persisted, the dog remained otherwise healthy with a good quality of life. To the authors’ knowledge, this is the first report to describe the concomitant association of those two disorders. Leptospirosis should be considered for any case of RTA in dogs.

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