A rare case report of neonatal calcinosis cutis induced by distant and delayed extravasation of intravenous calcium gluconate

A 3,480 g male neonate showed tachypnea symptom with a serum ionized calcium level of 0.66 mmol/L by routine clinical analysis. He was injected calcium gluconate intravenously through femoral vein catheter to treat the hypocalcemia. On second day after the injection, he started to show erythema in the flank area. The lesion became firm and changed into whitish crust consist of small crystals. Abdominal X-ray and ultrasonography showed the accumulation of calcium deposit in the subcutaneous layer of the lesion. Surgical debridement was performed to remove the crust with calcium deposit and acellular fish skin graft rich in omega-3 (Kerecis) was applied to the defect site for secondary intention of the defect wound. After 2 months, the skin and soft tissue defect were fully covered with healthy normal skin without depression or contracture. This report is a first case of iatrogenic calcinosis cutis without extravasation symptom.

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Juvenile dermatomyositis: a case of delayed recognition with unusual complication of nephrocalcinosis

BMJ Case Reports ◽

10.1136/bcr-2020-241152 ◽

2021 ◽

Vol 14 (4) ◽

pp. e241152

Author(s):

Geminiganesan Sangeetha ◽

Divya Dhanabal ◽

Saktipriya Mouttou Prebagarane ◽

Mahesh Janarthanan

Keyword(s):

Muscle Weakness ◽

Juvenile Dermatomyositis ◽

Inflammatory Myopathy ◽

Unusual Complication ◽

Ultrasound Screening ◽

Proximal Muscle Weakness ◽

Proximal Muscle ◽

Calcinosis Cutis ◽

First Case ◽

Medullary Nephrocalcinosis

Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in children and is characterised by the presence of proximal muscle weakness, heliotrope dermatitis, Gottron’s papules and occasionally auto antibodies. The disease primarily affects skin and muscles, but can also affect other organs. Renal manifestations though common in autoimmune conditions like lupus are rare in JDM. We describe a child whose presenting complaint was extensive calcinosis cutis. Subtle features of proximal muscle weakness were detected on examination. MRI of thighs and a muscle biopsy confirmed myositis. Nephrocalcinosis was found during routine ultrasound screening. We report the first case of a child presenting with rare association of dermatomyositis, calcinosis cutis and bilateral medullary nephrocalcinosis.

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Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis

Journal of the American Animal Hospital Association ◽

10.5326/15473317-37-4-370 ◽

2001 ◽

Vol 37 (4) ◽

pp. 370-373 ◽

Cited By ~ 14

Author(s):

JL Ruopp

Keyword(s):

Adult Male ◽

Vitamin D3 ◽

Calcium Gluconate ◽

Recent Literature ◽

Calcium Supplementation ◽

Direct Reaction ◽

Calcinosis Cutis ◽

Vitamin D3 Supplementation

An adult male cat presented to the Ontario Veterinary College after having a seizure at the humane society. The cat was diagnosed with primary hypoparathyroidism and was treated with calcium and vitamin D3 supplementation. Calcium supplementation included subcutaneous (SC) administration of diluted calcium gluconate according to protocols described in recent literature. Seven days after SC calcium administration, firm SC masses developed in the intrascapular area where the injections were given and in the dependent axillary area. These areas became raised, formed crusts, necrosed, and left scars. Although not histopathologically confirmed, the author postulates that this was a direct reaction to SC calcium gluconate administration.

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Neonate with calcinosis cutis following extravasation of calcium gluconate

Journal of Orthopaedic Science ◽

10.1007/s00776-007-1217-z ◽

2008 ◽

Vol 13 (3) ◽

pp. 269-272 ◽

Cited By ~ 12

Author(s):

Motoki Sonohata ◽

Takayuki Akiyama ◽

Ichiro Fujita ◽

Akihiko Asami ◽

Masaaki Mawatari ◽

...

Keyword(s):

Calcium Gluconate ◽

Calcinosis Cutis

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Severe calcinosis cutis associated with treatment of hypoparathyroidism in a dog

Journal of the American Animal Hospital Association ◽

10.5326/15473317-37-4-364 ◽

2001 ◽

Vol 37 (4) ◽

pp. 364-369 ◽

Cited By ~ 19

Author(s):

M Schaer ◽

PE Ginn ◽

LE Fox ◽

J Leon ◽

FM Ramirez

Keyword(s):

Calcium Gluconate ◽

Skin Necrosis ◽

Calcinosis Cutis ◽

Abdominal Skin ◽

Medical Evaluation

A 6-month-old, female border collie was referred for evaluation of hypocalcemia, hyperphosphatemia, fever, and painful ventral abdominal skin. She had recently been treated intravenously and subcutaneously (SC) with a diluted 10% calcium gluconate solution. The medical evaluation supported the diagnosis of primary hypoparathyroidism, but the subsequent hospital course was complicated by severe calcinosis cutis, which caused extensive skin necrosis and marked debilitation. This patient illustrates that administration of a calcium gluconate solution SC can be associated with extensive morbidity when administered to hyperphosphatemic patients.

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Chronic long bone osteomyelitis

10.1093/med/9780199550647.003.011001 ◽

2011 ◽

Author(s):

Peter Calder

Keyword(s):

Soft Tissues ◽

Chronic Osteomyelitis ◽

Free Tissue Transfer ◽

Free Flaps ◽

Autologous Bone Graft ◽

Bone Transport ◽

Soft Tissue Defect ◽

Long Bone ◽

Space Management ◽

Secondary Intention

Pathological features of chronic osteomyelitis♦ Necrotic bone♦ Compromised soft tissues with reduction in vascularity♦ Ineffective host response♦ Sequestrum formation♦ New bone formation from viable periosteum and endosteum♦ Formation of involucrum:Treatment principles in chronic osteomyelitis♦ Surgical debridement – remove all devitalized necrotic tissue♦ Dead space management:• Soft tissue defect – avoid healing by secondary intention. Consider local and free flaps• Bone defects – small structural with autologous bone graft, consider Papineau ‘open bone grafting’ where free tissue transfer is not an option, distraction osteogenesis with bifocal and bone transport for large defects including fibula transfer♦ Bone stability – movement needs to be eliminated♦ Antibiotic therapy – based on culture and sensitivity, local administration with PMMA beads or collagen sponge, Lautenbach procedure in resistant cases.

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Calcinosis Cutis Complicated by Compartment Syndrome Following Extravasation of Calcium Gluconate in a Neonate: A Case Report

Pediatrics & Neonatology ◽

10.1016/s1875-9572(10)60045-9 ◽

2010 ◽

Vol 51 (4) ◽

pp. 238-241 ◽

Cited By ~ 12

Author(s):

Tuo-Kang Chen ◽

Chueh-Yuan Yang ◽

Shu-Jen Chen

Keyword(s):

Case Report ◽

Compartment Syndrome ◽

Calcium Gluconate ◽

Calcinosis Cutis

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Calcinosis cutis in a newborn caused by minimal calcium gluconate extravasation

International Journal of Dermatology ◽

10.1111/j.1365-4632.2006.02693.x ◽

2006 ◽

Vol 45 (12) ◽

pp. 1439-1440 ◽

Cited By ~ 12

Author(s):

S. Domizio ◽

C. Puglielli ◽

E. Barbante ◽

G. Sabatino ◽

P. Amerio ◽

...

Keyword(s):

Calcium Gluconate ◽

Calcinosis Cutis

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Clinical analysis of percutaneous closure atrial septal defects guided by thoracic echocardiography (Report of 90 cases)

10.22541/au.163250869.90134928/v1 ◽

2021 ◽

Author(s):

chunping li ◽

Feng Huang

Keyword(s):

Pericardial Effusion ◽

Local Anesthesia ◽

Femoral Vein ◽

Clinical Analysis ◽

Percutaneous Closure ◽

Fast Recovery ◽

Residual Shunt ◽

Septal Defects ◽

Atrial Septal Defects

Objective :The purpose of this research is to explore the clinical application prospect of percutaneous closure atrial septal defects guided by thoracic echocardiography. Methods : Selected 90 inpatients who were pure atrial septal defects from sep 2014 to December 2019, Under local anesthesia via femoral vein puncture closure atrial septal defects guided by thoracic echocardiography, Real-time evaluatie plugging result.The patients underwent follow-up echocardiography at 3 days, 3 months, 6 months, 12 months after surgery．Results Intraoperative occlusion was not successful in 3 cases（The plug is not fixed firmly, so withdraw the plug）， Occluder were successfully implanted in 87 patients, there were no serious complications such as valvular injury、pericardial effusion、occluder off,five patients had a little residual shunt in 3 days after surgery, residual shunt disapper after 3 months underwent follow-up echocardiography, the rest of the patients does not appear residual shunt.. Conclusion :Percutaneous closure atrial septal defects guided by thoracic echocardiography had Superiority such as simplicity of operator、shorter operator time、less-injury、safety、fast recovery,the surgery has a broad clinic prospects．

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Absence of skin discoloration after transarterial embolization of a subcutaneous auricular arteriovenous malformation with PHIL

Interventional Neuroradiology ◽

10.1177/1591019916654441 ◽

2016 ◽

Vol 22 (5) ◽

pp. 606-610 ◽

Cited By ~ 4

Author(s):

Matthijs in ‘t Veld ◽

Peter WA Willems

Keyword(s):

Case Report ◽

Arteriovenous Malformation ◽

Arteriovenous Malformations ◽

Normal Skin ◽

Transarterial Embolization ◽

Superficial Temporal Artery ◽

Temporal Artery ◽

Embolic Agent ◽

First Case ◽

Posterior Auricular Artery

Background and objective One of the treatment options for arteriovenous malformations consists of embolization, with a choice of various embolic agents, with or without subsequent surgical excision. If embolization is offered without subsequent surgery, the embolic material will stay in situ, in which case the consistency and color become important in superficial lesions. The purpose of this case report is to describe if the use of a novel liquid embolic agent (PHIL) is well suited for treatment of superficial AVMs without subsequent surgery. Case description A 30-year-old male presented with a painful reddish, pulsatile swelling of the left ear that had been present for more than 10 years. Angiography confirmed an arteriovenous malformation supplied by the superficial temporal artery and the posterior auricular artery. The lesion was successfully treated by embolization with PHIL, through the superficial temporal artery. A minute residual shunt, from the posterior auricular artery, was accepted. Immediate disappearance of pulsatile tinnitus was reported. Moreover, return of normal skin color was observed without discomfort from the embolic deposits. This result has been stable throughout one year of clinical follow-up. Conclusion To our knowledge, this is the first case report describing PHIL embolization as a treatment option for superficial arteriovenous malformations without the necessity for subsequent surgery. The white color and rubbery consistency are beneficial characteristics of PHIL in treatment of subcutaneous lesions, especially in cosmetically relevant locations.

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