Primary hypoparathyroidism in a cat complicated by suspect iatrogenic calcinosis cutis

An adult male cat presented to the Ontario Veterinary College after having a seizure at the humane society. The cat was diagnosed with primary hypoparathyroidism and was treated with calcium and vitamin D3 supplementation. Calcium supplementation included subcutaneous (SC) administration of diluted calcium gluconate according to protocols described in recent literature. Seven days after SC calcium administration, firm SC masses developed in the intrascapular area where the injections were given and in the dependent axillary area. These areas became raised, formed crusts, necrosed, and left scars. Although not histopathologically confirmed, the author postulates that this was a direct reaction to SC calcium gluconate administration.

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Changes in serum 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in response to three vitamin D3 supplementation regimens

Endocrine Abstracts ◽

10.1530/endoabs.44.p72 ◽

2016 ◽

Author(s):

Jonathan Tang ◽

Holly Nicholls ◽

John Dutton ◽

Isabelle Piec ◽

Christopher Washbourne ◽

...

Keyword(s):

Vitamin D3 ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Vitamin D3 Supplementation ◽

25 Hydroxyvitamin D

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ORAL VITAMIN D3 SUPPLEMENTATION FOR CHILDHOOD PNEUMONIA

10.26226/morressier.58fa1767d462b80290b515d0 ◽

2017 ◽

Author(s):

Abner John Mondragon

Keyword(s):

Vitamin D3 ◽

Oral Vitamin ◽

Childhood Pneumonia ◽

Vitamin D3 Supplementation

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Faculty of 1000 evaluation for Serum 25-Hydroxyvitamin D Response to Vitamin D3 Supplementation 50,000 IU Monthly in Youth with HIV-1 Infection.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717955086.793466614 ◽

2012 ◽

Author(s):

John Eisman

Keyword(s):

Vitamin D3 ◽

Hydroxyvitamin D ◽

Vitamin D3 Supplementation ◽

25 Hydroxyvitamin D ◽

Hiv 1

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Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited

Nutrients ◽

10.3390/nu13051408 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1408

Author(s):

Hermann Brenner ◽

Sabine Kuznia ◽

Clarissa Laetsch ◽

Tobias Niedermaier ◽

Ben Schöttker

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Cancer Patients ◽

Body Mass ◽

Advanced Cancer ◽

Vitamin D3 ◽

Normal Weight ◽

The Body ◽

Published Data ◽

Vitamin D3 Supplementation

Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07–1.52, and RR, 1.44; 95% CI, 1.04–1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74–0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)—intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.

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Vitamin D Receptor (VDR) Allelic Variants Correlating with Response to Vitamin D3 Supplementation in Breast Cancer Survivors

Nutrition and Cancer ◽

10.1080/01635581.2020.1869790 ◽

2021 ◽

pp. 1-14

Author(s):

Elham Kazemian ◽

Sayed Hossein Davoodi ◽

Mohammad Esmaeil Akbari ◽

Nariman Moradi ◽

Safoora Gharibzadeh ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Cancer Survivors ◽

Vitamin D Receptor ◽

Vitamin D3 ◽

Breast Cancer Survivors ◽

Allelic Variants ◽

Vitamin D3 Supplementation

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Vitamin D3 supplementation of beef steers increases longissimus tenderness.

Journal of Animal Science ◽

10.2527/1999.774874x ◽

1999 ◽

Vol 77 (4) ◽

pp. 874 ◽

Cited By ~ 44

Author(s):

S S Swanek ◽

J B Morgan ◽

F N Owens ◽

D R Gill ◽

C A Strasia ◽

...

Keyword(s):

Vitamin D3 ◽

Beef Steers ◽

Vitamin D3 Supplementation

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Effects of oral vitamin D3 supplementation and supplement withdrawal on the accumulation of magnesium, calcium, and vitamin D in the serum, liver, and muscle tissue and subsequent carcass and meat quality of Bos indicus influenced cattle

Meat Science ◽

10.1016/j.meatsci.2006.06.024 ◽

2007 ◽

Vol 75 (1) ◽

pp. 150-158 ◽

Cited By ~ 9

Author(s):

N.C. Tipton ◽

D.A. King ◽

J.C. Paschal ◽

D.S. Hale ◽

J.W. Savell

Keyword(s):

Vitamin D ◽

Meat Quality ◽

Muscle Tissue ◽

Vitamin D3 ◽

Bos Indicus ◽

Oral Vitamin ◽

Vitamin D3 Supplementation

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Vitamin D and Serum Cytokines in a Randomized Clinical Trial

International Journal of Endocrinology ◽

10.1155/2010/305054 ◽

2010 ◽

Vol 2010 ◽

pp. 1-7 ◽

Cited By ~ 34

Author(s):

Eleanor Yusupov ◽

Melissa Li-Ng ◽

Simcha Pollack ◽

James K. Yeh ◽

Mageda Mikhail ◽

...

Keyword(s):

Vitamin D ◽

Placebo Group ◽

Vitamin D3 ◽

Intracellular Signaling ◽

Final Visit ◽

Active Vitamin ◽

Gm Csf ◽

Active Vitamin D ◽

Significant Difference ◽

Vitamin D3 Supplementation

Background. The role of vitamin D in the body's ability to fight influenza and URI's may be dependent on regulation of specific cytokines that participate in the host inflammatory response. The aim of this study was to test the hypothesis that vitamin D can influence intracellular signaling to regulate the production of cytokines.Subjects and Methods. This study was a 3-month prospective placebo-controlled trial of vitamin D3 supplementation in ambulatory adults [Li-Ng et al., 2009]. 162 volunteers were randomized to receive either 50 μg/d(2000 IU) of vitamin D3 or matching placebo. 25(OH)D and the levels of 10 different cytokines (IL-2, 4, 5, 6, 8, 10, 13, GM-CSF, IFN-γ, TNF-α) were measured in the serum of participants at baseline and the final visit. There were 6 drop-outs from the active vitamin D group and 8 from the placebo group.Results. In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (−62.9%,P<.0001), IFN-γ(−38.9%,P<.0001), IL-4 (−50.8%,P=.001), IL-8 (−48.4%,P<.0001), and IL-10 (−70.4%,P<.0001). In the placebo group, there were significant declines for GM-CSF (−53.2%,P=.0007) and IFN-γ(−34.4%,P=.0011). For each cytokine, there was no significant difference in the rate of decline between the two groups. 25(OH)D levels increased in the active vitamin D group from a mean of64.3±25.4 nmol/L to88.5±23.2 nmol/L.Conclusions. The present study did not show that vitamin D3 supplementation changed circulating cytokine levels among healthy adults.

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Comparison of functional outcomes between teriparatide and vitamin D3 in distal end radius fractures of osteoporotic patients

Journal of Research and Practice on the Musculoskeletal System ◽

10.22540/jrpms-05-035 ◽

2021 ◽

Vol 05 (01) ◽

pp. 35-40

Author(s):

Prakash D. Samant ◽

◽

Rohit M. Sane ◽

Rajendraprasad R. Butala ◽

Aditya M. Sane ◽

...

Keyword(s):

Vitamin D3 ◽

Functional Outcomes ◽

Therapeutic Option ◽

Patient Reported Outcome ◽

Radius Fractures ◽

Randomized Clinical Study ◽

Significant Difference ◽

Patient Reported ◽

Vitamin D3 Supplementation ◽

To Receive

Objectives: The objective of this study was to evaluate and compare the efficacy of teriparatide (osteoanabolic agent) versus vitamin D3 supplementation to improve functional outcomes in osteoporotic patients with distal end radius fractures (DERF). Methods: We conducted a prospective, randomized clinical study to compare the functional outcomes. Sixty osteoporotic DERF patients, treated with either conservative or surgical management were randomized to receive either teriparatide (20 mcg/day) or vitamin D3 (1000 IU/day) for a period of 3 months, along with calcium (500 mg/day) supplementation. The treatment outcomes were evaluated pre and post-management (1-month and 3-months) by Green and O’Brien scale, Patient-rated Wrist Evaluation (PRWE) scale, and Sarmiento scale. Results: There was a significant difference between the two groups at 3-months post-management. Teriparatide showed a significantly greater improvement of functional outcome (P=0.036) and patient-reported outcome (P<0.001) in comparison to vitamin D3 in total Green and O’Brien score and PRWE score, respectively. Conclusion: Teriparatide supplementation was effective and resulted in greater improvement in functional and radiologic outcomes in comparison to vitamin D3. Adjuvant teriparatide therapy may be a therapeutic option to improve the functional outcomes in DERF of osteoporotic patients.

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