scholarly journals Genetic polymorphism in the serotonin transporter gene-linked polymorphic region and response to serotonin reuptake inhibitors in patients with premature ejaculation

Clinics ◽  
2014 ◽  
Vol 69 (11) ◽  
pp. 710-713 ◽  
Author(s):  
E Ozbek ◽  
A Otunctemur ◽  
A Simsek ◽  
EC Polat ◽  
L Ozcan ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Serotonin Transporter ◽  
Serotonin Reuptake ◽  
Premature Ejaculation ◽  
Serotonin Reuptake Inhibitors ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region

scholarly journals The truth about genetic variation in the serotonin transporter gene and response to stress and medication

2011 ◽  
Vol 198 (6) ◽  
pp. 424-427 ◽  
Author(s):  
Peter McGuffin ◽  
Shaza Alsabban ◽  
Rudolf Uher
Keyword(s):  
Genetic Variation ◽  
Serotonin Transporter ◽  
Serotonin Reuptake ◽  
Serotonin Reuptake Inhibitors ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Review Of The Literature ◽  
Functional Variant ◽  
Response To Stress

SummaryThe question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

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