scholarly journals Inhibition of Triple-Negative Breast Cancer Tumor Growth by Electroacupuncture with Encircled Needling and Its Mechanisms in a Mice Xenograft Model

2019 ◽  
Vol 16 (12) ◽  
pp. 1642-1651
Author(s):  
Xin Jiang ◽  
Yehong Tian ◽  
Lin Xu ◽  
Qiaoli Zhang ◽  
Yuxiang Wan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Xenograft Model ◽  
Cancer Tumor

scholarly journals Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sofia M. Saraiva ◽  
Carlha Gutiérrez-Lovera ◽  
Jeannette Martínez-Val ◽  
Sainza Lores ◽  
Belén L. Bouzo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Xenograft Model ◽  
Skin Barrier ◽  
Zebrafish Embryos ◽  
Biorelevant Media

AbstractTriple negative breast cancer (TNBC) is known for being very aggressive, heterogeneous and highly metastatic. The standard of care treatment is still chemotherapy, with adjacent toxicity and low efficacy, highlighting the need for alternative and more effective therapeutic strategies. Edelfosine, an alkyl-lysophospholipid, has proved to be a promising therapy for several cancer types, upon delivery in lipid nanoparticles. Therefore, the objective of this work was to explore the potential of edelfosine for the treatment of TNBC. Edelfosine nanoemulsions (ET-NEs) composed by edelfosine, Miglyol 812 and phosphatidylcholine as excipients, due to their good safety profile, presented an average size of about 120 nm and a neutral zeta potential, and were stable in biorelevant media. The ability of ET-NEs to interrupt tumor growth in TNBC was demonstrated both in vitro, using a highly aggressive and invasive TNBC cell line, and in vivo, using zebrafish embryos. Importantly, ET-NEs were able to penetrate through the skin barrier of MDA-MB 231 xenografted zebrafish embryos, into the yolk sac, leading to an effective decrease of highly aggressive and invasive tumoral cells’ proliferation. Altogether the results demonstrate the potential of ET-NEs for the development of new therapeutic approaches for TNBC.

scholarly journals Integrin α9 depletion promotes β‐catenin degradation to suppress triple‐negative breast cancer tumor growth and metastasis

2019 ◽  
Vol 145 (10) ◽  
pp. 2767-2780 ◽  
Author(s):  
Zhishan Wang ◽  
Yunfei Li ◽  
Yajuan Xiao ◽  
Hsuan‐Pei Lin ◽  
Ping Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Tumor ◽  
Tumor Growth And Metastasis

scholarly journals Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer

2017 ◽  
Vol Volume 12 ◽  
pp. 7225-7237 ◽  
Author(s):  
Orleans Martey ◽  
Mhairi Nimick ◽  
Sebastien Taurin ◽  
Vignesh Sundararajan ◽  
Khaled Greish ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Maleic Acid ◽  
Triple Negative ◽  
Xenograft Model ◽  
Murine Xenograft Model

scholarly journals Raloxifene reduces triple-negative breast cancer tumor growth and decreases EGFR expression

2013 ◽  
Vol 43 (3) ◽  
pp. 785-792 ◽  
Author(s):  
SEBASTIEN TAURIN ◽  
KIRSTIE M. ALLEN ◽  
MARISSA J. SCANDLYN ◽  
RHONDA J. ROSENGREN
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Egfr Expression ◽  
Cancer Tumor
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