scholarly journals Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

2014 ◽  
Vol 15 (8) ◽  
pp. 3555-3559 ◽  
Author(s):  
Bo Li ◽  
Xin Zhao ◽  
Shao-Chun Dai ◽  
Wen Cheng
Keyword(s):  
Breast Cancer ◽  
Ultrasound Imaging ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Characteristics ◽  
Imaging Features

Magnetic Resonance Imaging Features in Triple-Negative Breast Cancer: Comparison With Luminal and HER2-Overexpressing Tumors

2012 ◽  
Vol 12 (5) ◽  
pp. 331-339 ◽  
Author(s):  
Melania Costantini ◽  
Paolo Belli ◽  
Daniela Distefano ◽  
Enida Bufi ◽  
Marialuisa Di Matteo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Imaging Features ◽  
Resonance Imaging

Distinct MR Imaging Features of Triple-Negative Breast Cancer with Brain Metastasis

2014 ◽  
Vol 25 (3) ◽  
pp. 474-481 ◽  
Author(s):  
Ren-Hua Yeh ◽  
Jyh-Cherng Yu ◽  
Chi-Hong Chu ◽  
Ching-Liang Ho ◽  
Hung-Wen Kao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Mr Imaging ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Imaging Features

Molecular Characteristics of Lymphocyte-predominant Triple-negative Breast Cancer

2021 ◽  
Vol 41 (4) ◽  
pp. 2133-2140
Author(s):  
RITSUKO SASAKI ◽  
YOSHIYA HORIMOTO ◽  
YUKA YANAI ◽  
AIKO KURISAKI-ARAKAWA ◽  
ATSUSHI ARAKAWA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Characteristics

Molecular Features and Functional Implications of Germline Variants in Triple-Negative Breast Cancer

2020 ◽  
Author(s):  
Ding Ma ◽  
Si-Yu Chen ◽  
Jin-Xiao Ren ◽  
Yu-Chen Pei ◽  
Cong-Wei Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Early Onset ◽  
Triple Negative ◽  
Parp Inhibitors ◽  
Chinese Patients ◽  
Molecular Characteristics ◽  
Germline Variants ◽  
Molecular Features ◽  
Germline Variant

Abstract Background The germline variant spectrum of triple-negative breast cancer (TNBC) is different from that of other subtypes and has demonstrated ethnic differences. However, the germline variants of TNBC among Chinese patients and its clinical significance remain unclear. Methods Using our multi-omics TNBC cohort (n = 325), we determined the spectrum of germline variants in TNBC and aimed to illustrate their biological and clinical implications. Results Overall, 16.0% (52 of 325) of TNBC patients harbored at least 1 pathogenic or likely pathogenic germline variant. These germline variants were associated with early onset of TNBC, the occurrence of contralateral breast cancer, the basal-like immune-suppressed mRNA subtype, and the homologous recombination deficiency (HRD) mutation subtype. Somatic allele-specific imbalance was observed in 54.1% of these germline variants, which was correlated with early onset of breast cancer and elevated HRD. The genes BRCA1 (7.4%), RAD51D (2.8%), and BRCA2 (2.2%) were those most frequently mutated. The RAD51D germline variants, especially K91fs, were enriched in Chinese patients with TNBC compared with Caucasian and African American patients. The Chinese-specific RAD51D germline variants were functionally associated with the instability of the RAD51D protein, HRD, and sensitivity to PARP inhibitors. Conclusions Chinese TNBC patients have a distinct spectrum of germline variants, with a remarkable impact on the clinical and molecular characteristics of the tumor. Integrative germline-somatic analysis may help identify TNBC patients who are most likely to be affected by their germline variants and in performing clinical interventions more precisely. The RAD51D variants enriched in our cohort may serve as therapeutic targets and guide precision treatment of TNBC.

scholarly journals Molecular characteristics of recurrent triple-negative breast cancer

2015 ◽  
Vol 12 (5) ◽  
pp. 7326-7334 ◽  
Author(s):  
CHUNG-HSIN TSAI ◽  
JEN-HWEY CHIU ◽  
CHU-WEN YANG ◽  
JIR-YOU WANG ◽  
YI-FANG TSAI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Characteristics

scholarly journals Immune-related biomarkers in triple-negative breast cancer

Breast Cancer ◽  
2021 ◽  
Author(s):  
Juan Zhang ◽  
Qi Tian ◽  
Mi Zhang ◽  
Hui Wang ◽  
Lei Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Combined Treatment ◽  
Tumor Infiltrating Lymphocytes ◽  
Molecular Characteristics ◽  
Immune Gene ◽  
Breast Cancers ◽  
Related Factors ◽  
Molecular Features

AbstractBreast cancer is a commonly diagnosed female cancer in the world. Triple-negative breast cancer (TNBC) is the most dangerous and biologically aggressive subtype in breast cancer which has a high mortality, high rates of relapse and poor prognosis, representing approximately 15–20% of breast cancers. TNBC has unique and special biological molecular characteristics and higher immunogenicity than other breast cancer types. On the basis of molecular features, TNBC is divided into different subtypes and gets various treatments. Especially, immunotherapy becomes a promising and effective treatment to TNBC. However, not all of the TNBC patients are sensitive to immunotherapy, the need of selecting the patients suitable for immunotherapy is imperative. In this review, we discussed recent discoveries about the immune-related factors of TNBC, including tumor-infiltrating lymphocytes (TILs), programmed death-ligand protein-1 (PD-L1), immune gene signatures, some other emerging biomarkers for immunotherapy effectivity and promising biomarkers for immunotherapy resistance. In addition, we summarized the features of these biomarkers contributing to predict the prognosis and effect of immunotherapy. We hope we can provide some helps or evidences to clinical immunotherapy and combined treatment for TNBC patients.

scholarly journals Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45831 ◽  
Author(s):  
Wen-Hung Kuo ◽  
Yao-Yin Chang ◽  
Liang-Chuan Lai ◽  
Mong-Hsun Tsai ◽  
Chuhsing Kate Hsiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Study ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Characteristics ◽  
Breast Carcinomas
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