Traumatic Digital Amputations of the Foot Inflicted by Pet Cat upon Individual with Diabetic Peripheral Neuropathy

2013 ◽  
Vol 103 (5) ◽  
pp. 441-444 ◽  
Author(s):  
William Hoffman ◽  
Kenneth Donovan
Keyword(s):  
Peripheral Neuropathy ◽  
Lower Extremity ◽  
Diabetic Peripheral Neuropathy ◽  
Relevant Literature ◽  
Pet Ownership ◽  
Common Cause ◽  
Potential Risks

Diabetic peripheral neuropathy (DPN) is a common cause of many lower-extremity complications. This case study illustrates the potential perils of pet ownership associated with diabetes and neuropathy. The case describes an incident resulting in traumatic digital amputations inflicted by a patient’s pet feline while she was sleeping. In presenting this case, the potential risks of pet ownership for patients with DPN are discussed along with a review of the relevant literature. (J Am Podiatr Med Assoc 103(5): 441–444, 2013)

scholarly journals Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
L. B. L. Prabodha ◽  
N. D. Sirisena ◽  
V. H. W. Dissanayake
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Genetic Factors ◽  
Genome Wide Association Study ◽  
Hospital Admissions ◽  
Relevant Literature ◽  
Cellular Level ◽  
Diabetic Patients ◽  
Factors Associated ◽  
Complex Process

Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations. The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative stress and altered polyol metabolism that changes the nerve microvasculature, altered growth factor support, and deregulated lipid metabolism. Recent literature has reported that there are several heterogeneous groups of susceptible genetic loci which clearly contribute to the development of DPN. Several studies have reported that some patients with prediabetes develop neuropathic complications, whereas others demonstrated little evidence of neuropathy even after long-standing diabetes. There is emerging evidence that genetic factors may contribute to the development of DPN. This paper aims to provide an up-to-date review of the susceptible and prognostic genetic factors associated with DPN. An extensive survey of the scientific literature published in PubMed using the search terms “Diabetic peripheral neuropathy/genetics” and “genome-wide association study” was carried out, and the most recent and relevant literature were included in this review.

scholarly journals Lower extremity MRI following 10-week supervised exercise intervention in patients with diabetic peripheral neuropathy

2021 ◽  
Vol 9 (1) ◽  
pp. e002312
Author(s):  
Ryan Brown ◽  
Azadeh Sharafi ◽  
Jill M Slade ◽  
Antonio Convit ◽  
Nathan Davis ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Lower Extremity ◽  
Diabetic Peripheral Neuropathy ◽  
Intervention Program ◽  
Exercise Intervention ◽  
Tibial Nerve ◽  
Control Period ◽  
Response To Therapy ◽  
Measurement Sensitivity ◽  
Supervised Exercise

IntroductionThe purpose of this study was to characterize using MRI the effects of a 10-week supervised exercise program on lower extremity skeletal muscle composition, nerve microarchitecture, and metabolic function in individuals with diabetic peripheral neuropathy (DPN).Research design and methodsTwenty participants with DPN completed a longitudinal trial consisting of a 30-day control period, during which subjects made no change to their lifestyle, followed by a 10-week intervention program that included three supervised aerobic and resistance exercise sessions per week targeting the upper and lower extremities. The participants’ midcalves were scanned with multinuclear MRI two times prior to intervention (baseline1 and baseline2) and once following intervention to measure relaxation times (T1, T1ρ, and T2), phosphocreatine recovery, fat fraction, and diffusion parameters.ResultsThere were no changes between baseline1 and baseline2 MRI metrics (p>0.2). Significant changes (p<0.05) between baseline2 and postintervention MRI metrics were: gastrocnemius medialis (GM) T1 –2.3%±3.0% and soleus T2 –3.2%±3.1%. Trends toward significant changes (0.05<p<0.1) between baseline2 and postintervention MRI metrics were: calf adipose infiltration –2.6%±6.4%, GM T1ρ –4.1%±7.7%, GM T2 –3.5%±6.4%, and gastrocnemius lateral T2 −4.6±7.4%. Insignificant changes were observed in gastrocnemius phosphocreatine recovery rate constant (p>0.3) and tibial nerve fractional anisotropy (p>0.6) and apparent diffusion coefficient (p>0.4).ConclusionsThe 10-week supervised exercise intervention program successfully reduced adiposity and altered resting tissue properties in the lower leg in DPN. Gastrocnemius mitochondrial oxidative capacity and tibial nerve microarchitecture changes were not observed, either due to lack of response to therapy or to lack of measurement sensitivity.

Impact of diabetes mellitus duration on effect of lower extremity nerve decompression in 1,526 diabetic peripheral neuropathy patients

2014 ◽  
Vol 156 (7) ◽  
pp. 1329-1333 ◽  
Author(s):  
Wenxiang Zhong ◽  
Wenchuan Zhang ◽  
Min Yang ◽  
Guowei Li ◽  
Qiufeng Ma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Lower Extremity ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Decompression
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