Multiple Schwannomas of the Lower Extremity

2020 ◽  
Vol 110 (5) ◽  
Author(s):  
Joseph T. Watson ◽  
Jorge A. Hernandez ◽  
Rusheena Bartlett
Keyword(s):  
Soft Tissue Mass ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Resonance Imaging ◽  
Mosaic Pattern ◽  
Tissue Mass ◽  
Pathologic Analysis ◽  
Multiple Schwannomas

This case study presents a 72-year-old male patient who presented with multiple schwannomas. The patient underwent several soft-tissue mass excisions performed by general surgery and podiatry. The physical examination displayed multiple nodules on the left foot, ankle, and previously in the groin. Magnetic resonance imaging displayed high–T2-weighted signal masses in the left plantar heel and ankle. These masses were excised and, through pathologic analysis, were diagnosed as schwannomas. Immunohistochemistry displayed a mosaic pattern of INI1 expression, a gene associated with tumor suppression. The patient demonstrated findings consistent with multiple schwannomas (eg, schwannomatosis or neurofibromatosis type 2). Because of the patient's medical history, neurofibromatosis type 2 was more probable.

Schwannomatosis in a child – or early neurofibromatosis type 2

2002 ◽  
Vol 116 (7) ◽  
pp. 551-555 ◽  
Author(s):  
A. M. Shaida ◽  
D. G. O’Donovan ◽  
D. A. Moffat
Keyword(s):  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Age Group ◽  
Distinct Entity ◽  
Genetic Features ◽  
Paediatric Age ◽  
Multiple Schwannomas

A case of multiple cervical schwannomas in a five-year-old boy, without other evidence of neurofibromatosis type 2, is described. Schwannomatosis is a disorder characterized by the presence of multiple schwannomas in the absence of neurofibromatosis type 2 that has only been recognized in the last 15 years. The clinical and genetic features of neurofibromatosis types 1 and 2 and schwannomatosis are compared and contrasted. This patient with possible schwannomatosis is presented to illustrate the potential pitfalls of making this diagnosis in the paediatric age group and to increase awareness of the debate on whether this is a distinct entity or a form fruste of neurofibromatosis type 2.

Neurofibroma of the hard palate

2021 ◽  
Vol 14 (4) ◽  
pp. e239887
Author(s):  
Bethany Cartwright ◽  
Kenneth Corsar
Keyword(s):  
Soft Tissue ◽  
Hard Palate ◽  
Soft Tissue Mass ◽  
Treatment Options ◽  
Neurofibromatosis Type ◽  
Incisional Biopsy ◽  
Tissue Mass ◽  
Benign Tumours

Neurofibromas are defined as benign tumours arising from peripheral nerve sheaths. Few intraoral palatal cases have been reported. Neurofibromas can occur as part of neurofibromatosis, type 1 (NF1) or type 2 (NF2). A 41-year-old patient presented with a slowly enlarging soft tissue mass on the hard palate. An incisional biopsy was performed, which confirmed the diagnosis of a neurofibroma associated with NF1. It should be considered that there is a chance of malignant transformation. Here, we discuss the clinical features, types, diagnosis, histopathology and treatment options.

Neurofibromatosis II

2014 ◽  
Vol 6 (3) ◽  
pp. 4-6
Author(s):  
Rashmi Sharma ◽  
Parmod Kalsotra ◽  
Rohan Gupta ◽  
Saurabh Gupta ◽  
Nitika Gupta ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Resonance Imaging ◽  
Multiple Neoplasms ◽  
Chief Complaints ◽  
Neurofibromatosis Type Ii ◽  
Whole Spine ◽  
Bilateral Acoustic Neuroma

ABSTRACT Neurofibromatosis type II is an inherited autosomal dominant syndrome, characterized by multiple neoplasms of the central and peripheral nervous system associated with ocular abnormalities. The most common tumor associated with the disease is the vestibulocochlear schwannoma, and as many as 10% of patients with this tumor have neurofibromatosis type 2. In this report, we aim to present a 36-year-old female who presented with chief complaints of unilateral tinnitus, and, during her workup, which included cranial and whole spine magnetic resonance imaging, we found bilateral acoustic neuroma with multiple meningiomas. Based on clinical and imaging findings, the diagnosis of neurofibromatosis type 2 was made.

Schwannomatosis/neurofibromatosis type 2 associated multiple schwannomas visualized on FDG-PET/CT

2013 ◽  
Vol 32 (4) ◽  
pp. 275-276
Author(s):  
V. Beylergil ◽  
S. Haque ◽  
A. Carver ◽  
M.H. Bilsky ◽  
J.A. Carrasquillo
Keyword(s):  
Fdg Pet ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Multiple Schwannomas

scholarly journals An Uncommon Case of Neurofibromatosis Type 2: A Tribute to the Intracranial Calcifications

2013 ◽  
Vol 3 ◽  
pp. 21 ◽  
Author(s):  
Anıl Ozgür ◽  
Yasemin Karaman ◽  
Feramuz Demır Apaydin ◽  
Meltem Nass Duce
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Imaging Techniques ◽  
Genetic Disorder ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Resonance Imaging ◽  
Intracranial Calcifications ◽  
Uncommon Case

Neurofibromatosis Type 2 (NF2) is a genetic disorder associated with schwannomas, meningiomas, and ependymomas. Intracranial calcifications, either tumoral or non-tumoral, are relatively lesser known features of NF2. Here, we present a case of NF2, in which the diagnosis was suspected due to the presence of choroid plexus and subependymal calcifications, although no obvious schwannoma or meningioma was detected initially on standard computed tomography or magnetic resonance imaging. This case highlights the importance of further evaluation with appropriate imaging techniques.

Sign in / Sign up

Export Citation Format

Share Document