scholarly journals Author response: Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

2016 ◽  
Author(s):  
Abhishek Kulkarni ◽  
Deniz Ertekin ◽  
Chi-Hon Lee ◽  
Thomas Hummel
Keyword(s):  
Visual System ◽  
Birth Order ◽  
Growth Cone ◽  
Author Response ◽  
Dependent Growth

scholarly journals Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Abhishek Kulkarni ◽  
Deniz Ertekin ◽  
Chi-Hon Lee ◽  
Thomas Hummel
Keyword(s):  
Visual System ◽  
Birth Order ◽  
Growth Cone ◽  
Neural Circuit ◽  
Growth Cones ◽  
Initial Growth ◽  
Developmental Context ◽  
Differential Positioning ◽  
Dependent Growth ◽  
Relative Differences

The precise recognition of appropriate synaptic partner neurons is a critical step during neural circuit assembly. However, little is known about the developmental context in which recognition specificity is important to establish synaptic contacts. We show that in the Drosophila visual system, sequential segregation of photoreceptor afferents, reflecting their birth order, lead to differential positioning of their growth cones in the early target region. By combining loss- and gain-of-function analyses we demonstrate that relative differences in the expression of the transcription factor Sequoia regulate R cell growth cone segregation. This initial growth cone positioning is consolidated via cell-adhesion molecule Capricious in R8 axons. Further, we show that the initial growth cone positioning determines synaptic layer selection through proximity-based axon-target interactions. Taken together, we demonstrate that birth order dependent pre-patterning of afferent growth cones is an essential pre-requisite for the identification of synaptic partner neurons during visual map formation in Drosophila.

Author response for "The brain of the African wild dog. IV . The visual system"

2020 ◽  
Author(s):  
Samson Chengetanai ◽  
Adhil Bhagwandin ◽  
Mads F. Bertelsen ◽  
Therese Hård ◽  
Patrick R. Hof ◽  
...  
Keyword(s):  
Visual System ◽  
Author Response ◽  
African Wild Dog ◽  
Wild Dog ◽  
The Brain

scholarly journals Afferent Growth Cone Interactions Control Synaptic Specificity in the Drosophila Visual System

Neuron ◽  
2000 ◽  
Vol 28 (2) ◽  
pp. 427-436 ◽  
Author(s):  
Thomas R Clandinin ◽  
S.Lawrence Zipursky
Keyword(s):  
Visual System ◽  
Growth Cone ◽  
Synaptic Specificity

scholarly journals  2-Chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse

2007 ◽  
Vol 104 (41) ◽  
pp. 16347-16352 ◽  
Author(s):  
L. Shi ◽  
W.-Y. Fu ◽  
K.-W. Hung ◽  
C. Porchetta ◽  
C. Hall ◽  
...  
Keyword(s):  
Growth Cone ◽  
Growth Cone Collapse ◽  
Dependent Growth
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