scholarly journals Author response: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

2016 ◽  
Author(s):  
Kristopher McEown ◽  
Yohko Takata ◽  
Yoan Cherasse ◽  
Nanae Nagata ◽  
Kosuke Aritake ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Rem Sleep ◽  
Sleep Loss ◽  
Author Response ◽  
Sucrose Consumption

scholarly journals Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Kristopher McEown ◽  
Yohko Takata ◽  
Yoan Cherasse ◽  
Nanae Nagata ◽  
Kosuke Aritake ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Rem Sleep ◽  
Causal Link ◽  
Sleep Loss ◽  
Sucrose Consumption ◽  
Rem Sleep Deprivation ◽  
Fat Consumption ◽  
Neuronal Inhibition ◽  
Medial Pfc ◽  
First Time

Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.

scholarly journals Sleep’s Role in Schema Learning and Creative Insights

2021 ◽  
Author(s):  
Simon J. Durrant ◽  
Jennifer M. Johnson
Keyword(s):  
Prefrontal Cortex ◽  
Cognitive Control ◽  
Medial Prefrontal Cortex ◽  
Rem Sleep ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Schema Theory ◽  
Key Characteristics ◽  
Increased Activity ◽  
Novel Associations

Abstract Purpose of Review A recent resurgence of interest in schema theory has influenced research on sleep-dependent memory consolidation and led to a new understanding of how schemata might be activated during sleep and play a role in the reorganisation of memories. This review is aimed at synthesising recent findings into a coherent narrative and draw overall conclusions. Recent Findings Rapid consolidation of schematic memories has been shown to benefit from an interval containing sleep. These memories have shown reduced reliance on the hippocampus following consolidation in both humans and rodents. Using a variety of methodologies, notably including the DRM paradigm, it has been shown that activation of a schema can increase the rate of false memory as a result of activation of semantic associates during slow wave sleep (SWS). Memories making use of a schema have shown increased activity in the medial prefrontal cortex, which may reflect both the schematic activation itself and a cognitive control component selecting an appropriate schema to use. SWS seems to be involved in assimilation of new memories within existing semantic frameworks and in making memories more explicit, while REM sleep may be more associated with creating entirely novel associations while keeping memories implicit. Summary Sleep plays an important role in schematic memory consolidation, with more rapid consolidation, reduced hippocampal involvement, and increased prefrontal involvement as the key characteristics. Both SWS and REM sleep may have a role to play.

Author response for "Play, but not observing play, engages rat medial prefrontal cortex"

2020 ◽  
Author(s):  
Miguel Concha‐Miranda ◽  
Konstantin Hartmann ◽  
Annika Reinhold ◽  
Michael Brecht ◽  
Juan I. Sanguinetti‐Scheck
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Author Response

scholarly journals Author response: Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

2020 ◽  
Author(s):  
Stavros Trakoshis ◽  
Pablo Martínez-Cañada ◽  
Federico Rocchi ◽  
Carola Canella ◽  
Wonsang You ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Author Response ◽  
Intrinsic Excitation

scholarly journals Author response: Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion

2017 ◽  
Author(s):  
Masashi Kondo ◽  
Kenta Kobayashi ◽  
Masamichi Ohkura ◽  
Junichi Nakai ◽  
Masanori Matsuzaki
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Calcium Imaging ◽  
Author Response ◽  
Two Photon
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