scholarly journals Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Kristopher McEown ◽  
Yohko Takata ◽  
Yoan Cherasse ◽  
Nanae Nagata ◽  
Kosuke Aritake ◽  
...  

Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.

1974 ◽  
Vol 39 (3) ◽  
pp. 1135-1141 ◽  
Author(s):  
V. Zarcone ◽  
A. De La Pena ◽  
W. C. Dement

The study demonstrates a behavioral effect of selective sleep disturbance in normal human Ss. Ten male Ss were selectively REM-deprived for two nights by awakening them at the onset of REM sleep. In addition, there were baseline and non-REM awakening conditions. Heightened sexual interest was defined by the number of film frames (using a Mackworth camera) in which Ss fixated on parts of the female figure in photographs. The largest mean difference in sexual interest was found between baseline and REM-deprivation. Both the non-REM awakenings and REM-sleep deprivation enhanced sexual interest. The failure to demonstrate a significant difference between REM-deprivation and non-REM awakenings may be due to the fact that Ss were REM-sleep-deprived in both conditions. It is suggested that REM-sleep loss may lead to increased selective attention and preoccupation with any cues which are usually interesting.


2013 ◽  
Vol 36 (6) ◽  
pp. 629-630 ◽  
Author(s):  
Victor I. Spoormaker ◽  
Michael Czisch ◽  
Florian Holsboer

AbstractNeuroimaging studies show that episodic memory encoding is associated with increased activity in hippocampus and lateral prefrontal cortex; however, the latter structure shows decreased activity in rapid eye movement (REM) sleep. Together with few episodic memory traces in REM sleep, and REM sleep deprivation affecting hippocampus-independent emotional processes, this argues for generic information processing in REM sleep rather than linking episodic memory traces.


2021 ◽  
Author(s):  
Sang-Min Kim ◽  
Seungjae Zhang ◽  
Jiwon Park ◽  
Hyun Jae Sung ◽  
Thuy-Duong Thi Tran ◽  
...  

1967 ◽  
Vol 24 (3) ◽  
pp. 851-858 ◽  
Author(s):  
H. W. AGNEW ◽  
WILSE B. WEBB ◽  
ROBERT L. WILLIAMS

2019 ◽  
Vol 109 ◽  
pp. 1563-1568
Author(s):  
Mohammad Nasehi ◽  
Ameneh Shirkhodaei ◽  
Mohaddeseh Ebrahimi-Ghiri ◽  
Mohammad-Reza Zarrindast

SLEEP ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 37-41 ◽  
Author(s):  
Hiromi Ohno ◽  
Ryo Urushihara ◽  
Hiroyoshi Sei ◽  
Yusuke Morita

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