Evaluation of Estrogen level in Oral Contraceptive Pills used by the women with cerebral venous- sinus thrombosis

Advances in Bioscience and Clinical Medicine ◽

10.7575/aiac.abcmed.ca1.16 ◽

2017 ◽

pp. 16

Author(s):

Abdolreza Ghoreishi

Keyword(s):

Oral Contraceptive ◽

Sinus Thrombosis ◽

Muslim Women ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Oral Contraceptive Pills ◽

Venous Sinus Thrombosis ◽

Estrogen Level ◽

Contraceptive Effect ◽

Contraceptive Pills

Introduction: Muslim women are not allowed to perform religious ceremonies in menstrual period. Some of them use oral contraceptive pills (OCPs) to delay menstruation, which can lead to cerebral venous - sinus thrombosis (CVST). Therefore, the incidence of CVST is significantly higher in Iranian women. Thrombosis incidence is directly related to estrogen level of OCPs. In this study, the estrogen level of OPCs was evaluated in a group of female CVST patients.Methods: This study was conducted from 2010 to 2011, including two consecutive months of Ramadan in Zanjan Province of Iran. The remaining tablets of patients with CVST and OCP consumption history were analyzed by HPLC method.Results: Of 32 female CVST patients, 27 patients had a history of OCPs consumption. 24 cases of them consumed LD. Analysis of LD tablets revealed normal level of estrogen except for one case.Conclusion: Using contraceptive products among Muslim women in incorrect manner to delay menstruation should be considered by healthcare system. It is recommended to decrease amount of estrogen in OCPs till their contraceptive effect is unaffected.

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Etiological associations of Cerebral Venous Sinus Thrombosis (CVT) among Sudanese patients in Khartoum state Neurological Centers, Sudan, 2020

10.21203/rs.3.rs-530219/v1 ◽

2021 ◽

Author(s):

Mohamed Malekaldar ◽

Abbasher Hussien ◽

Khabab Abbasher Hussien Mohamed Ahmed ◽

Yassin Abdalla

Keyword(s):

Oral Contraceptive ◽

Sinus Thrombosis ◽

Post Partum ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Oral Contraceptive Pills ◽

Venous Sinus Thrombosis ◽

Contraceptive Pills ◽

Work Up ◽

Treatable Condition

Abstract Background As cerebral venous sinus thrombosis is common in our country and it carries a high risk of morbidity and mortality if it is not detected and treated early. The common aetiological associations of CVST are post-partum, pregnancy and oral contraceptive pills. Objectives To study the etiological association of CVST among Sudanese patients in Khartoum state in neurological centers. Methodology This is a descriptive prospective hospital based study was conducted on CVST patients in four neurological centers in Khartoum state in the period from March to October 2020. Results Sixty patients were studied for etiological association of CVST using standardized questionnaire including medical history, clinical examination, investigation and treatment. The most common etiological association were pregnancy in 15(25%) OCP in 11(18.3) and being in the post-partum period in 23(38.3%). Recommendation Cerebral venous sinus thrombosis is a treatable condition and has good outcome. Early detection of patients and performing suitable work up including thrombophilia and connective tissue disease screening is essential. Conclusion Post-partum, pregnancy and oral contraceptive pills were the most common etiological associations of cerebral venous sinus thrombosis compared with other populations.

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