scholarly journals Triorganotin(IV) Complexes of Schiff Base Derived from Glycine: Synthesis, CharacteristicSpectral Studies and Antifungal Activity

2013 ◽  
Vol 2 (2) ◽  
pp. 389-394 ◽  
Author(s):  
ROBINA AMAN ◽  
GARIMA MATELA ◽  
MANJU LATA UPADHYAY ◽  
TRIPTI GANGWAR
Keyword(s):  
Schiff Base ◽  
Antifungal Activity ◽  
Glycine Synthesis

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

2019 ◽  
Vol 15 (6) ◽  
pp. 648-658 ◽  
Author(s):  
Manzoor Ahmad Malik ◽  
Shabir Ahmad Lone ◽  
Parveez Gull ◽  
Ovas Ahmad Dar ◽  
Mohmmad Younus Wani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Fungal Infections ◽  
Total Sterol ◽  
Antifungal Drugs ◽  
New Drugs ◽  
Ergosterol Biosynthesis ◽  
Dependent Manner ◽  
Schiff Base Derivatives

Background: The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required. Methods: We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs- fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates. Results: A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies. Conclusion: The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.

A hexanuclear Nd (III) complex derived from a Schiff base with significant antitumor and antifungal activity

2020 ◽  
Author(s):  
Lijuan Hua ◽  
Wenge Li ◽  
Yan Chen ◽  
Kai Liang ◽  
He Cai ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antifungal Activity

scholarly journals Nontoxic Cobalt(III) Schiff Base Complexes with Broad‐Spectrum Antifungal Activity

2020 ◽  
Author(s):  
Angelo Frei ◽  
A. Paden King ◽  
Gabrielle J. Lowe ◽  
Amy K. Cain ◽  
Francesca L. Short ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antifungal Activity ◽  
Broad Spectrum ◽  
Schiff Base Complexes

scholarly journals Non-toxic Cobalt(III) Schiff Base Complexes with Broad Spectrum Antifungal Activity

2020 ◽  
Author(s):  
Angelo Frei ◽  
A. Paden King ◽  
Gabrielle J. Lowe ◽  
Amy K. Cain ◽  
Francesca L. Short ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antifungal Activity ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
Fungal Infections ◽  
Antifungal Drugs ◽  
New Drugs ◽  
Schiff Base Complexes ◽  
In Vivo Studies

Resistance to currently available antifungal drugs has quietly been on the rise but overshadowed by the alarming spread of antibacterial resistance. There is a striking lack of attention to the threat of drug resistant fungal infections, with only a handful of new drugs currently in development. Given that metal complexes have proven to be useful new chemotypes in the fight against diseases such as cancer, malaria, and bacterial infections, it stands to reason to explore their possible utility in treating fungal infections. Herein we report a series of cobalt(III) Schiff base complexes with broad spectrum antifungal activity. Some of these complexes (1-3) show minimum inhibitory concentrations (MIC) in the low micro- to nanomolar range against a series of Candida and Cryptococcus yeasts. Additionally, we demonstrate that these compounds show no cytotoxicity against both bacterial and human cells. Finally, we report first in vivo toxicity data on these compounds in Galleria mellonella, showing that doses as high as 266 mg/kg are tolerated without adverse effects, paving the way for further in vivo studies of these complexes. <br>

scholarly journals Design of cinnamaldehyde amino acid Schiff base compounds based on the quantitative structure–activity relationship

2017 ◽  
Vol 4 (9) ◽  
pp. 170516 ◽  
Author(s):  
Hui Wang ◽  
Mingyue Jiang ◽  
Shujun Li ◽  
Chung-Yun Hse ◽  
Chunde Jin ◽  
...  
Keyword(s):  
Schiff Base ◽  
Amino Acid ◽  
Antifungal Activity ◽  
Fungal Infections ◽  
Atomic Orbital ◽  
Quantitative Structure Activity Relationship ◽  
Quantitative Structure ◽  
Structure Activity ◽  
Qsar Models ◽  
Amino Acid Schiff Base

Cinnamaldehyde amino acid Schiff base (CAAS) is a new class of safe, bioactive compounds which could be developed as potential antifungal agents for fungal infections. To design new cinnamaldehyde amino acid Schiff base compounds with high bioactivity, the quantitative structure–activity relationships (QSARs) for CAAS compounds against Aspergillus niger ( A. niger ) and Penicillium citrinum (P. citrinum) were analysed. The QSAR models ( R 2  = 0.9346 for A. niger , R 2  = 0.9590 for P. citrinum, ) were constructed and validated. The models indicated that the molecular polarity and the Max atomic orbital electronic population had a significant effect on antifungal activity. Based on the best QSAR models, two new compounds were designed and synthesized. Antifungal activity tests proved that both of them have great bioactivity against the selected fungi.

Synthesis, spectral and thermal characterization, biological activity of a new amino acide ester containing substituted salicylaldimine Schiff base ligand and its Ru(II)bipyridyl complex

2021 ◽  
Vol 20 (2) ◽  
pp. 193-202
Author(s):  
Çiğdem Yörür-Göreci ◽  
Nilay Altaş-Puntar ◽  
Abdullah Toraman ◽  
Nebahat Demirhan
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Fluorescence Spectroscopy ◽  
Schiff Base Ligand ◽  
Thermal Characterization ◽  
Bidentate Ligand ◽  
Dsc Analyses ◽  
Bipyridyl Complex

The new salicylaldimine, as O,N-bidentate ligand (HL), containing amino acide ester and its Ru(II) complex [Ru(bpy)2(HL)]Cl2 have been prepared. Synthesized compounds have been structurally characterized by IR, 1H NMR, LC-MS, fluorescence spectroscopy, elemental and thermal (TGA-DSC) analyses. The metal to the ligand ratio of the Ru(II) complex was found to be 1:1. Antifungal activities of the ligand and complex have been investigated. The Ru(II) complex have strong antifungal activity than the ligand against Aspergillus niger.

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