scholarly journals Novel visual analytics approach for chromosome territory analysis

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12661
Author(s):  
Magdalena A. Tkacz ◽  
Kornel Chromiński ◽  
Dominika Idziak-Helmcke ◽  
Ewa Robaszkiewicz

This document presents a new and improved, more intuitive version of a novel method for visually representing the location of objects relative to each other in 3D. The motivation and inspiration for developing this new method came from the necessity for objective chromosome territory (CT) adjacency analysis. The earlier version, Distance Profile Chart (DPC), used octants for 3D orientation. This approach did not provide the best 3D space coverage since space was divided into just eight cones and was not intuitive with regard to orientation in 3D. However, the version presented in this article, called DPC12, allows users to achieve better space coverage during conification since space is now divided into twelve cones. DPC12 is faster than DPC and allows for a more precise determination of the location of objects in 3D. In this article a short introduction about the conification idea is presented. Then we explain how DPC12 is designed and created. After that, we show DPC12 on an instructional dataset to make it easier to understand and demonstrate how they appear and how to read them. Finally, using DPC12 we present an example of an adjacency analysis (AA) using the model of Chromosome Territories (CTs) distribution in the rice nucleus.

Nature ◽  
1965 ◽  
Vol 206 (4985) ◽  
pp. 710-710 ◽  
Author(s):  
D. T. DIXON ◽  
M. L. MCGLASHAN

2011 ◽  
Vol 107 (22) ◽  
Author(s):  
S. S. Henshaw ◽  
M. W. Ahmed ◽  
G. Feldman ◽  
A. M. Nathan ◽  
H. R. Weller

1955 ◽  
Vol 4 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Kai Siegbahn

2013 ◽  
Vol 316-317 ◽  
pp. 279-285
Author(s):  
Xin Rong Wen ◽  
Chang Qing Tu

The paper presents a novel method for the separation/enrichment of trace Co2+ using microcrystalline phenolphthalein modified with 8-hydroxyquinoline (HQ) prior to the determination by spectrophotometry. The effects of different parameters,such as the dosages of phenolphthalein and HQ,various salts and acidity on the enrichment yield of Co2+ have been investigated to select the experimental conditions. The possible enrichment mechanism of Co2+ was discussed.The results showed that under the optimum conditions, Co2+ could be quantificationally adsorbed on the surface of microcrystalline phenolphthalein in the form of the chelate precipitate of Co(HQ)2 ,while K+,Na+,Ca2+,Mg2+,Cd2+,Zn2+,Mn2+,Fe2+ and Al3+ could not be adsorbed at all.Therefore,Co2+ was completely separated from the above metal ions in the solution. A new method for the spectrophotometric determination of trace cobalt after separation/enrichment using microcrystalline phenolphthalein modified with 8-hydroxyquinoline was established.The proposed method has been successfully applied to the determination of Co2+ in various environmental water samples, and the results agreed well with those obtained by FAAS method.


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