Choosing the right pain relief for patients with soft-tissue injuries

Objective To determine whether 3% w/w levomenthol added to ibuprofen gel (5% w/w) improves its efficacy compared with ibuprofen gel alone or diclofenac gel (1.16%) for the treatment of soft-tissue injuries. Methods A total of 182 patients with acute soft-tissue injuries participated in a randomised, single-blind, single-dose study to assess the efficacy and safety of three topical analgesic gels. Efficacy was assessed as the score change in a numeric rating scale for pain. Results The median time to significant pain relief was 20 minutes for the ibuprofen/levomenthol and diclofenac gels but 25 minutes for ibuprofen gel. At 2 hours, significantly more patients treated with ibuprofen/levomenthol gel reported a cooling sensation (45.8%) compared with diclofenac (16.4%) or ibuprofen (14.7%) gels, and both ibuprofen/levomenthol and diclofenac gels provided significantly more effective global pain relief compared with ibuprofen gel. Few adverse events and no serious adverse events related to study medication were recorded. Conclusions Although all gels effectively relieved pain, both ibuprofen/levomenthol and diclofenac gels provided superior global pain relief compared with ibuprofen gel, with a shorter median time to significant pain relief. Only ibuprofen/levomenthol gel provided cooling for up to 2 hours. None of the gels were associated with serious safety concerns. EudraCT No 2015-005240-33 EU Clinical Trials Register URL: https://www.clinicaltrialsregister.eu/ctr-search/search

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Soft Tissue Coverage for Defects around the Knee Joint

Indian Journal of Plastic Surgery ◽

10.1055/s-0039-1688536 ◽

2019 ◽

Vol 52 (01) ◽

pp. 125-133

Author(s):

Ravindra Bharathi R. ◽

Sanjai Ramkumar ◽

Hari Venkatramani

Keyword(s):

Soft Tissue ◽

Knee Joint ◽

Soft Tissue Injuries ◽

Soft Tissue Coverage ◽

Anatomical Basis ◽

Tissue Injuries ◽

The Right

AbstractSoft tissue injuries around the knee present a challenge for providing a cover when there is loss of tissue. Various flaps comprising of skin and muscles around the joint have been described. Understanding the anatomical basis and the design of these flaps can aid in choosing the right flap for a given situation. A prompt cover of the defects aids in quicker healing and quicker rehabilitation of the patient.

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The Complex Femoral injuries after Hippopotamus Bite.

Albanian Journal of Trauma and Emergency Surgery ◽

10.32391/ajtes.v5i2.233 ◽

2021 ◽

Vol 5 (2) ◽

pp. 879-882

Author(s):

Fedor Kovalenko ◽

Pantelis Vassiliu ◽

Konstantinos Degiannis ◽

Dietrich Doll

Keyword(s):

Soft Tissue ◽

Major Trauma ◽

Case Reports ◽

American Woman ◽

Soft Tissue Injuries ◽

Wild Animals ◽

Wound Debridement ◽

Tissue Injuries ◽

The Right ◽

Large Animals

Introduction. Attacks by large animals, which lead to a critical patient condition, have not been systematically and statistically analyzed in the previous literature. Some papers about animal attacks are case reports and address fatal cases. Hippopotamus bite injury is a major trauma associated with complications. Case report. In 2018, an American woman celebrating her 37th birthday in Zimbabwe embarked on a river rafting trip. After the hippopotamus bite, the patient had extensive soft tissue injuries and a comminuted fracture of the right femur. It was undertaken extensive multiple wound debridement and the femur was nailed as the site of entrance of the nail was away from the soft tissue injuries. Conclusion. Usually, hippopotami avoid contact with people. Similar to many wild animals, hippopotami can attack in anticipation of danger, especially when protecting their offspring. In the present case, the inflicted injury is severe and has a combined character.

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