scholarly journals Rare Co-existence of Squamous Cell Carcinoma with Infiltration of Renal Vein and Xanthogranulomatous Pyelonephritis

Author(s):  
K.V Kanodia
2016 ◽  
Vol 11 (3) ◽  
pp. 2179-2181 ◽  
Author(s):  
ZHAO WANG ◽  
BIN YAN ◽  
YONG-BAO WEI ◽  
NA HU ◽  
QIN SHEN ◽  
...  

2011 ◽  
Vol 1 ◽  
pp. 9 ◽  
Author(s):  
Jennifer Rothschild ◽  
Shweta Bhatt ◽  
Vikram S. Dogra

Collision tumor is a rare condition in which two neoplasms (usually benign and malignant), both growing in the same general area, collide with each other and become intermingled. We present histopathology and imaging correlation of xanthogranulomatous pyelonephritis coexistent with squamous cell carcinoma and osteogenic sarcoma of the kidney.


Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 128-133
Author(s):  
Tsung-Hsin Chang ◽  
Jen-Shu Tseng

Abstract Case presentation In the current study, we report a 69-year-old female patient who was initially diagnosed with xanthogranulomatous pyelonephritis (XGPN) with nephrolithiasis and a peri-renal abscess. She presented to our department with right flank pain. Physical examination revealed right costovertebral angle knocking pain and computed tomography revealed dilated calyces and one staghorn stone over right kidney, with multiple abscess accumulations over the right peri-renal region. Right radical nephrectomy was performed using a transperitoneal flank approach, and pathology revealed squamous cell carcinoma (SCC) with concurrent XGPN. The patient was alive at 4 months post-operative follow-up. To the best of our knowledge, this is only the fifth case of renal SCC with concurrent XGPN reported in the English medical literature. Conclusion Renal SCC with coexisting XGPN is an extremely rare presentation and only four cases have been previously reported in the English medical literature. A positive diagnosis for this rare combination of diseases was established, based on pathological and immunohistochemical examinations after radical nephrectomy. Poor prognosis has been reported in such cases. Malignancies should be considered in patients with a long-standing history of urolithiasis.


2017 ◽  
Vol 4 (4) ◽  
pp. 1501 ◽  
Author(s):  
Varun Gautam P. ◽  
Manjusha M. Litake

Squamous cell carcinoma (SCC) of the kidney is a rare entity. Often it is confused with Xanthogranulomatous Pyelonephritis (XGP), which is a chronic inflammatory disorder of the kidney, associated with the destruction of the renal parenchyma usually in the setting of an infectious process.  A 76 year old male presented with right flank pain and vomiting. On examination, was found to have tenderness with localized guarding in the right flank. Investigations revealed a mass arising from the lower pole of the right kidney which was hydronephrotic and had features suggestive of stage III xanthogranulomatous pyelonephritis (XGP) with pyonephrosis and the presence of multiple calculi. Patient initially underwent a drainage of the pyonephrosis and subsequent nephrectomy.  Histopathology revealed the presence of both XGP and SCC in the resected kidney specimen. Chronic nephrolithiasis is a predisposing factor for both XGP and SCC. XGP shares many characteristics with SCC in terms of both its radiographic appearance and its ability to involve the adjacent structures. Chronic nephrolithiasis is a predisposing factor for both XGP and SCC. XGP shares many characteristics with SCC in terms of both its radiographic appearance and its ability to involve the adjacent structures.


2021 ◽  
Vol 6 (3) ◽  
pp. 242-244
Author(s):  
Prachi ◽  
Gaurav Sharma ◽  
Vikas Jain

Primary Squamous cell carcinoma of the renal pelvis is rare and accounts to only 0.5- 0.8 % of malignant renal tumours having poor prognosis. Chronic irritation, inflammation and infection induce the pathogenesis of this malignancy. A 53 year old male patient, presented with left flank pain since one month. On radiological investigation, his CT revealed atrophic shrunken left kidney measuring 7.9x5.2cms showing significant parenchymal thinning and complete loss of corticomedullary differentiation. A left upper ureteric calculus is seen measuring 7.5 mm with significant left renal hydronephrosis.Clinically, it was diagnosed as Xanthogranulomatous Pyelonephritis. Grossly the radical nephrectomy specimen measures 10.5x5.5x3.5cm. External surface is irregular & bosselated. On Cut surface renal architecture is effaced by necrotic mass measuring 9.5x5.0x3.0 cm involving pelvic ureter and most of renal parenchyma.Hematoxylin and eosin stained tissue revealed characteristic feature such as keratin pearls and intracellular bridges seen, rendering the diagnosis of well-differentiated keratinising squmaous cell carcinoma seen with 40% tumour necrosis associated with Keratinizing Squamous Dysplasia. In the present case, obstructive uropathy has triggered the event of malignancy. The radiologic differential diagnosis includes primary and secondary renal neoplasms and xanthogranulomatous pyelonephritis associated with renal calculi. XGP is commonly associated with lithiasis however, rarely causes keratinizing squamous metaplasia and its manifestations closely mimic renal neoplasm, leading to misdiagnosis of malignancy.The prognosis is dismal with a 5-year survival rate of <10%. CT and MRI play a crucial role in diagnosis and staging of these tumors, though histology always remains confirmatory and diagnostic.


2020 ◽  
Vol 9 (1) ◽  
pp. 7
Author(s):  
Mosab Abdalla Ali Alzubier ◽  
Ahmed Eltyeb Ibrahim ◽  
Sami Mahjoub Taha

Background: Squamous cell carcinoma (SCC) which originated in the urothelium of the urological system is not uncommon; however, it is rare in the renal pelvis. Additionally, it is hard to be diagnosed without high clinical suspicion.Case summary: A-66-years old female presented with left loin pain for 6 years, hematuria, and fever for months. Examination revealed no abnormality apart from pallor and bimanually palpable left kidney. Her investigations showed normal renal function and anemia, Computer Topography for Kidney, Ureter, and Bladder (CT-KUB) revealed a large left renal pelvic stone with a hugely enlarged kidney with suspicion of xanthogranulomatous pyelonephritis (XGPN), with almost absent function of the left kidney in DTPA. She underwent Left trans-peritoneal radical nephrectomy. Post-operative histopathology result was moderately differentiated squamous cell carcinoma (T3, N0, M0). To our knowledge this was the first reported case in our hospital, we think that the treatment was fair putting in mind the poor prognosis of the condition and the difficulty in diagnosis.Conclusion: This case demonstrates renal pelvis SCC presented with radiological features suggestive of xanthogranulomatous pyelonephritis.  


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