Amniotic fluid volume in large-for-gestational-age fetuses of nondiabetic mothers.

Background: The amniotic fluid is fundamental for proper fetal development and growth. Ultrasound visualization of the amniotic fluid permits both subjective and objective estimates of the amniotic fluid. Objective: The objective of this study was to determine the reference values of normal single deepest pocket (SDP) – upper and lower limits, mean SDP and variation of the SDP with gestational age among Igbo women of South-Eastern Nigeria extraction carrying uncomplicated singleton pregnancy. Methodology: This was a prospective cross sectional study involving 400 women carrying uncomplicated singleton pregnancies and who were sure of the date of the first day of their last menstrual period. The single deepest pocket / maximum vertical pool were determined once at presentation at the hospital.. The study was conducted from January 1st to December 31st 2015. The second author carried out all the scanning. The SDP was obtained. Results: The womens’ mean and median ages were the same at 28 years. The gestational age range of the pregnancies was 14-41 weeks. The mean SDP was 5.8cm, while the 5th and 95th percentiles were 3.3cm and 8.5cm respectively. There was no difference in the mean SDP in both term and preterm. There was irregular but continuous rise of mean SDP to a peak of 6.8cm at gestational age of 39 weeks. In conclusion, the participants had a mean SDP of 5.8cm. There was also a positive correlation between SDP and Gestational age. We therefore recommend a longitudinal study to assess perinatal outcome and abnormal amniotic fluid volume among Igbo women of South-Eastern Nigeria. Key words: Single Deepest Pocket, Uncomplicated Singleton Pregnancy, Igbo Women.

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Four-quadrant assessment of gestational age-specific values of amniotic fluid volume in uncomplicated pregnancies

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1034/j.1600-0412.1998.770306.x ◽

1998 ◽

Vol 77 (3) ◽

pp. 290-294 ◽

Cited By ~ 1

Author(s):

Mohammed Haider Alley ◽

Alexander Hadjiev ◽

Valentina Mazneikova ◽

Angel Dimitrov

Keyword(s):

Amniotic Fluid ◽

Gestational Age ◽

Fluid Volume ◽

Amniotic Fluid Volume ◽

Four Quadrant

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Prediction of small for gestational age newborns using ultrasound estimated and actual amniotic fluid volume: Published data revisited

Australian and New Zealand Journal of Obstetrics and Gynaecology ◽

10.1111/j.1479-828x.2008.00830.x ◽

2008 ◽

Vol 48 (2) ◽

pp. 160-164 ◽

Cited By ~ 6

Author(s):

Suneet P. CHAUHAN ◽

Everett F. MAGANN ◽

Dorota A. DOHERTY ◽

Christopher S. ENNEN ◽

Amy NIEDERHAUSER ◽

...

Keyword(s):

Amniotic Fluid ◽

Gestational Age ◽

Small For Gestational Age ◽

Fluid Volume ◽

Published Data ◽

Amniotic Fluid Volume

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Amniotic fluid volume and fetal swallowing rate in sheep

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1985.249.1.r133 ◽

1985 ◽

Vol 249 (1) ◽

pp. R133-R138 ◽

Cited By ~ 6

Author(s):

S. Tomoda ◽

R. A. Brace ◽

L. D. Longo

Keyword(s):

Amniotic Fluid ◽

Red Blood Cells ◽

Gestational Age ◽

Blood Cells ◽

Volume Measurement ◽

Fluid Volume ◽

Fetal Weight ◽

Amniotic Cavity ◽

Amniotic Fluid Volume ◽

Pregnant Sheep

To investigate amniotic fluid (AF) dynamics and volume regulatory mechanisms, we measured the concentration of radioiodinated (125I) serum albumin (RISA), 51Cr-labeled red blood cells (Cr-RBC), and 103Ru-labeled microspheres after injection into the amniotic cavity and determined AF volume and fetal swallowing rate in 22 singleton pregnant sheep. Under normal conditions 2-3 h were required for complete mixing of RISA and Cr-RBC within AF; however, when the fetus was dead only 3-5 h were required. AF volume of 17 sheep on the 5th postoperative day averaged 975 +/- 128 ml by RISA and 986 +/- 130 ml by Cr-RBC. AF volume determined with RISA and Cr-RBC correlated well. In contrast, AF volume measurement with microspheres produced erratic results. The disappearance rate of the labels in 17 ewes on the 5th postoperative day averaged 4.9 +/- 0.7%/h for RISA and 5.5 +/- 0.7 for Cr-RBC, and the calculated rates of fetal swallowing were 935 +/- 78 ml/day by RISA and 1,085 +/- 102 by Cr-RBC. In dead fetuses the disappearance rates were almost zero, suggesting that the labels disappear mainly by swallowing. Absolute volume swallowed and swallowed volume per fetal weight correlated with gestational age. AF volume correlated with fetal weight. Radiolabeled albumin or red blood cells may be used to simultaneously measure amniotic fluid volume and the rate of fetal swallowing. Furthermore it appears that fetal swallowing increases with gestational age.

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Prenatal Megacystis – Is Prediction of Outcome and Renal Function Possible?

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0043-105263 ◽

2017 ◽

Vol 39 (04) ◽

pp. 407-412 ◽

Cited By ~ 1

Author(s):

Regina Tschannen ◽

Rita Gobet ◽

Josef Wisser

Keyword(s):

Renal Function ◽

Amniotic Fluid ◽

Gestational Age ◽

Fluid Volume ◽

Amniotic Fluid Volume ◽

Age Related ◽

Age Dependent ◽

Fetal Urine ◽

Beta 2 ◽

Beta 2 Microglobulin

Abstract Objective To assess prenatal prognostic criteria for fetuses with megacystis in order to counsel parents. Methods In a retrospective observational study at a single tertiary referral center, we assessed the clinical course of 53 fetuses with megacystis cared for at the Department of Obstetrics of the University Hospital Zurich between 1995 and 2008 and followed them up for 2 to 12 years. We determined fetal karyotype, amniotic fluid volume and fetal urinary biochemistry as prenatal prognostic factors. The renal function of survivors was grouped according to age-related creatinine values. Using logistic regression analysis, gestational age-dependent discrimination curves and corresponding ROC curves for fetal urine, beta-2 microglobulin, osmolarity and chloride were calculated. Results 43 out of 53 fetuses underwent vesicocentesis, and spontaneous remission occurred in 3 fetuses. 15 fetuses survived, termination of pregnancy was requested in 23 cases, and 12 neonatal and 3 intrauterine deaths were observed. Reduced amniotic fluid volume showed a significant (p = 0.0027) increase of impaired renal function or perinatal death. Discrimination between survivors and non-survivors was complete for fetal urine beta-2 microglobulin with an area under the curve (AUC) of 1.0. For fetal urine osmolarity and fetal urinary chloride, the AUC was 0.81 and 0.76, respectively. Conclusion The assessment of prognosis for fetal megacystis should include fetal k aryotyping, determination of amniotic fluid and assessment of fetal urine biochemistry. Gestational age-dependent regression lines disclose clinically relevant discrimination and can be used as selection criteria for fetal interventions and parental counselling.

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Four-quadrant assessment of gestational age-specific values of amniotic fluid volume in uncomplicated pregnancies

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/j.1600-0412.1998.770306.x ◽

1998 ◽

Vol 77 (3) ◽

pp. 290-294 ◽

Cited By ~ 9

Author(s):

MohammedHaider Alley ◽

Alexander Hadjiev ◽

Valentina Mazneikova ◽

Angel Dimitrov

Keyword(s):

Amniotic Fluid ◽

Gestational Age ◽

Fluid Volume ◽

Amniotic Fluid Volume ◽

Four Quadrant

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Therapeutic amnioinfusion in oligohydramnios during pregnancy (excluding labor)

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174445 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4577

Author(s):

Mahvish Qazi ◽

Najmus Saqib ◽

Abida Ahmad ◽

Imran Wagay

Keyword(s):

Amniotic Fluid ◽

Gestational Age ◽

Perinatal Outcome ◽

Latency Period ◽

Fluid Volume ◽

P Value ◽

Normal Delivery ◽

Neonatal Deaths ◽

Amniotic Fluid Volume ◽

The Mean

Background: Oligohydramnios is a serious complication of pregnancy that is associated with a poor perinatal outcome and complicates 1-5% of pregnancies. The purpose of this study was to evaluate the role of antepartum transabdominal amnioinfusion on amniotic fluid volume/latency period in pregnancies with oligohydramnios.Methods: This study was conducted in the Department of Obstetrics and Gynaecology at Sher-i-Kashmir Institute of Medical Sciences Soura Srinagar. In this study, a total of 54 pregnant women with ultrasonographically diagnosed oligohydramnios i.e. AFI < 5 cm and gestational age of >24 weeks were taken for therapeutic amnioinfusion and its effects on amniotic fluid volume were studied. Statistical Software SPSS (Version 20.0) and Microsoft excel were used to carry out the statistical analysis of data. P-value less than 0.05 was considered statistically significant.Results: Mean age of patients in our study was 27.5±3.19 years and gestational age group of 28-34 weeks. The mean AFI pre and post amnioinfusion was found to be 3.3 cm and 8.8 cm respectively. The difference was found to be statistically significant with a p value of <0.001. There was increase in the latency period in the studied patients with a mean latency period of 42.8±14.94 days. Mean number of transabdominal amnioinfusions in our study was 1.48±0.64. In our study, majority of patients i.e. 33 (61.1%) delivered at 38-40 weeks with a mean age at delivery 37.4±1.92 weeks. In our study, maximum number of patients i.e. 32 (59.3%) were delivered by full term normal delivery and only 15 (27.8%) required caesarean section. 78% of newborns weighed >2.5kg. The mean weight of newborn was 2.9±0.59 kgs. The incidence of newborn admissions to NICU was 20.4%. Number of neonatal deaths in our study was 5.6%. There was reduction of neonatal admission to NICU and neonatal deaths after transabdominal amnioinfusion.Conclusions: Antepartum transabdominal amnioinfusion is a useful procedure to reduce complications resulting from decreased intra-amniotic volume. It significantly raises the amniotic fluid especially useful in preterm pregnancies, where the procedure allows for a better perinatal outcome by significantly prolonging the duration of pregnancy, increasing birth weight, preventing fetal distress and thereby reducing operative intervention. Optimizing the selection of patients who are good candidates for the procedure is a prerequisite.

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