DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF EBASTINE IN BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD

<strong>Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Famotidine is a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer. The aim of the present research work was to develop accurate and rapid Area under Curve Method to determine Ibuprofen and Famotidine in combined dosage form. The Area under Curve method, wavelength range selected are 259-269 nm for Ibuprofen and 282-292 nm for Famotidine respectively. The developed method was obeyed the Beer’s law and was f</strong><strong>ound linearity range between 80-640 μg/ml for IBU and 2-22 μg/ml for Famotidine; while the correlation coefficient were 0.9985 for Ibuprofen and 0.9982 for Famotidine. Parameters such as linearity, accuracy, precision, LOD and LOQ values were used for validation of the methods as per ICH guidelines for both methods. Intra and inter-day precision %RSD values were less than 2%. This method is found suitable for day to day analysis of Ibuprofen and Famotidine in combined dosage form.</strong>

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Development and validation of area under curve spectrophotometry method for ternary mixture of dextromethorphan HBr, doxylamine succinate and pseudoephedrine HCl in tablet dosage form

10.1063/5.0045551 ◽

2021 ◽

Author(s):

Rida Evalina Tarigan ◽

Muchlisyam ◽

Siti Morin Sinaga ◽

Zul Alfian

Keyword(s):

Ternary Mixture ◽

Area Under Curve ◽

Dosage Form ◽

Development And Validation ◽

Tablet Dosage

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Spectrophotometric simultaneous determination of Empagliflozin and Metformin in combined tablet dosage form by absorbance corrected method, area under curve method, and dual wavelength spectrophotometry.

Asian Journal of Research in Chemistry ◽

10.5958/0974-4150.2019.00021.x ◽

2019 ◽

Vol 12 (2) ◽

pp. 94

Author(s):

Sushil D. Patil ◽

Swapnapurti V Bharambe ◽

Tejashri R. Dugaje ◽

Sanjay Kshirsagar

Keyword(s):

Simultaneous Determination ◽

Area Under Curve ◽

Dosage Form ◽

Dual Wavelength ◽

Curve Method ◽

Tablet Dosage

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Simultaneous Estimation and Validation of Artemether and Lumefantrine by UV Spectrophotometry in Tablet

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i2.4576 ◽

2021 ◽

Vol 11 (2) ◽

pp. 16-22

Author(s):

Megha Mishra ◽

Anand Mundada

Keyword(s):

Spectrophotometric Method ◽

Area Under Curve ◽

Dosage Form ◽

Spectroscopic Method ◽

Simultaneous Estimation ◽

Uv Spectrophotometry ◽

Ich Guidelines ◽

Curve Method ◽

Tablet Dosage

A UV spectrophotometric method has been developed for the simultaneous determination of Artemether and Lumefantrine. The spectroscopic method for estimation of Artemether and Lumefantrine employed Area under curve method for analysis using Ethanol as solvent. Artemether has absorbance maxima 253.2 nm and Lumefantrine has absorbance maxima 235.2 nm and both these drugs obey Beer's law in concentration range of 4.24 -67.84 μg/ml for Artemether and 4.68 -28.08 μg/ml for Lumefantrine. The recovery studies ascertained the accuracy of the purposed method and the results were validated as per ICH guidelines. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of Artemether and Lumefantrine in tablet dosage form without the interference of common excipients. Keywords: Artemether, Lumefantrine; Area under curve; Simultaneous; Estimation

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