scholarly journals A REVIEW ON RATIONAL DRUG DESIGN APPROACH: NOVEL TOOL FOR DRUG DISCOVERY

2018 ◽  
Vol 9 (6) ◽  
pp. 17-21
Author(s):  
Ashok Kumar ◽  
Parthasarathi S
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Rational Drug Design ◽  
Design Approach ◽  
Rational Drug

scholarly journals Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Ser-Xian Phua ◽  
Kwok-Fong Chan ◽  
Chinh Tran-To Su ◽  
Jun-Jie Poh ◽  
Samuel Ken-En Gan
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Antibody Engineering ◽  
Rational Drug Design ◽  
Biomedical Science ◽  
Great Promise ◽  
Holistic View ◽  
Rational Drug ◽  
Big Picture ◽  
Reductionist Approach

AbstractThe reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the sum of its parts. With experimental, technological, and computational advances, we can now do more than view parts in isolation, thus we propose that an increasing holistic view (where a protein is investigated as much as a whole as possible) is now timely. To further advocate this, we review and discuss several studies and applications involving allostery, where distant protein regions can cross-talk to influence functionality. Therefore, we believe that an increasing big picture approach holds great promise, particularly in the areas of antibody engineering and drug discovery in rational drug design.

Antimalarial Drug Discovery: In Silico Structural Biology and Rational Drug Design

2009 ◽  
Vol 9 (3) ◽  
pp. 304-318 ◽  
Author(s):  
TAP de Beer ◽  
GA Wells ◽  
PB Burger ◽  
F. Joubert ◽  
E. Marechal ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Structural Biology ◽  
Antimalarial Drug ◽  
In Silico ◽  
Rational Drug Design ◽  
Rational Drug

Rational Drug Design Approach for Overcoming Drug Resistance:  Application to Pyrimethamine Resistance in Malaria

1998 ◽  
Vol 41 (9) ◽  
pp. 1367-1370 ◽  
Author(s):  
James H. McKie ◽  
Kenneth T. Douglas ◽  
Cecil Chan ◽  
Simon A. Roser ◽  
Robert Yates ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Design ◽  
Rational Drug Design ◽  
Design Approach ◽  
Rational Drug

scholarly journals CURRENT PROGRESS IN STRUCTURE-BASED RATIONAL DRUG DESIGN MARKS A NEW MINDSET IN DRUG DISCOVERY

2013 ◽  
Vol 5 (6) ◽  
pp. e201302011 ◽  
Author(s):  
Valère Lounnas ◽  
Tina Ritschel ◽  
Jan Kelder ◽  
Ross McGuire ◽  
Robert P. Bywater ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Rational Drug Design ◽  
Rational Drug
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