scholarly journals The Influence of Smoking on Choroidal, Macular and Retinal Nerve Fiber Layer Thickness

2021 ◽  
pp. 46-55
Author(s):  
Mona Ahmed El Rokh ◽  
Raouf Ahmed Gaber ◽  
Elsaed Ebrahem Eldesoky ◽  
Hamouda Hamdy Ghoraba
Keyword(s):  
Nerve Fibre ◽  
Choroidal Thickness ◽  
Substantial Reduction ◽  
Vascular Diseases ◽  
Retinal Nerve Fibre Layer ◽  
Peripheral Blood Flow ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Smoking Group ◽  
The Impact

Background: Smoking is one of the most serious health hazards because it affects every organ in our bodies. Cigarette smoking increases the chance of developing systemic and ocular vascular diseases significantly. Although the exact mechanism behind the association between ocular vascular disorders and smoking are unknown, the peripheral vasoconstriction action of nicotine is believed to lead to an increase in peripheral blood flow resistance. This study was designed to examine the impact of smoking with Spectral Domain Optical Coherence Tomography (SD-OCT) on the peripapillary retinal nerve fibre (RNFL), macular, and choroidal thickness. Methods: This prospective study was done on 50. It included 25 healthy cigarette smokers with no systemic or ocular illness and another 25 age- and gender-matched healthy non-smokers. Results: The smoking group had a substantial reduction in central macular and choroidal thickness as compared to the nonsmoker group. The RNFL peripapillary thickness across groups was not significantly altered, with the exception of the temporal (T) quadrant which was significantly thinner in the smoking group. This study discovered a substantial negative correlation between peripapillary RNFL, central macular thickness, and smoking exposure. Conclusions: Smoking reduces the mean thickness of the peripapillary retinal nerve fibre layer (particularly in the temporal quadrant), the choroidal layer, and the central macular layer statistically significantly.

Influence of uveitis on Bruch’s membrane opening minimum rim width and retinal nerve fibre layer thickness measurements

2018 ◽  
Vol 103 (10) ◽  
pp. 1413-1417 ◽  
Author(s):  
Matthias F Kriegel ◽  
Arnd Heiligenhaus ◽  
Carsten Heinz
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fibre Layer ◽  
Bruch’S Membrane Opening ◽  
Nerve Fibre Layer ◽  
Active Inflammation ◽  
The Impact

Background/aimsTo assess the impact of papillary leakage and active inflammation on optical coherence tomography (OCT)-based retinal nerve fibre layer thickness (RNFLT) and Bruch’s membrane opening minimum rim width (BMO-MRW) measurements in uveitic eyes with and without secondary glaucoma.MethodsProspective, single-centre analysis of patients with uveitis. All patients included received a fluorescein angiography examination and an OCT scan measuring the BMO-MRW and the RNFLT in three concentric peripapillary ring scans.ResultsOverall, 95 eyes of 56 patients were enrolled. Papillary leakage and active inflammation were present in 39 (41%) and 57 (60%) eyes, respectively. Twenty-one eyes were classified as glaucomatous; 10 of those glaucomatous eyes showed papillary leakage. Both BMO-MRW and RNFLT measurements were significantly increased in eyes with papillary leakage (BMO-MRW: p=0.0001; RNFLT: first to third ring (p<0.0001)). Active inflammation led to a significantly thickened RNFLT (first ring: p=0.0026; second ring: p=0.0009; third ring: p=0.0002) while only a trend towards increased values could be observed in the BMO-MRW measurements (p=0.3063). Glaucomatous eyes with papillary leakage demonstrated significantly higher values on both BMO-MRW and RNFLT measurements than glaucomatous eyes without leakage (BMO-MRW: p=0.0159; RNFLT: first ring: p=0.0062; second ring: p=0.0037; third ring: p=0.0197). No significant difference could be observed between glaucomatous eyes with leakage and non-glaucomatous eyes without leakage (BMO-MRW: p=0.4132; RNFLT: first ring: p=0.5412; second ring: p=0.3208; third ring: p=0.1164).ConclusionsThe OCT scanning parameters BMO-MRW and RNFLT were significantly influenced by papillary leakage in uveitic eyes with and without glaucoma. RNFLT values were also significantly increased while active inflammation was present. In patients with uveitis, these OCT-based imaging tools should be interpreted with caution, especially in those with papillary leakage or active inflammation.

scholarly journals The Impact of Migraine on Posterior Ocular Structures

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Süleyman Demircan ◽  
Mustafa Ataş ◽  
Sevgi Arık Yüksel ◽  
Melek D. Ulusoy ◽  
İsa Yuvacı ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Healthy Controls ◽  
Ischemic Insult ◽  
Fiber Layer ◽  
Horizontal Section ◽  
Rnfl Thickness ◽  
Migraine Group ◽  
The Mean ◽  
The Impact ◽  
The Relationship

Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls.Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The RNFL and macular thicknesses were analysed with standard OCT protocol while choroidal thickness was analysed with EDI protocol in all subjects. Choroidal thickness was measured at the fovea, 1500 µm nasal and 1500 µm temporal to the fovea in a horizontal section.Results. The mean RNFL thickness for nasal and nasal inferior sectors was significantly thinner (P≤0.018) in the migraineurs’ eyes than in those of the controls, as was the mean choroid thickness at the fovea and measured points (P<0.0001). However, the mean macular thickness was not significantly different between the groups.Conclusions. This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.

scholarly journals Retinal nerve fiber layer thickness and retinal vessel calibers in children with thalassemia minor

2016 ◽  
Vol 4 ◽  
pp. 205031211666168 ◽  
Author(s):  
Semra Acer ◽  
Yasemin I Balcı ◽  
Gökhan Pekel ◽  
Tuğba T Ongun ◽  
Aziz Polat ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Retinal Vessel ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Thalassemia Minor ◽  
Retinal Nerve Fiber

Objectives: Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with thalassemia minor. Methods: In this cross-sectional and comparative study, 30 thalassemia minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. Results: There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups ( p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in thalassemia minor group ( p < 0.05). Conclusion: There is increased retinal arterioral and venular calibers in children with thalassemia minor compared with controls.

Changes in retinal oxygen saturation, choroidal thickness, and retinal nerve fibre layer

2015 ◽  
Vol 50 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Shaolin Du ◽  
Xinbo Gao ◽  
Xiulan Zhang ◽  
Jiawei Wang ◽  
Wenbin Huang ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Nerve Fibre ◽  
Choroidal Thickness ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer
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